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Spaca1 sperm acrosome associated 1 [ Mus musculus (house mouse) ]

Gene ID: 67652, updated on 27-Nov-2024

Summary

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Official Symbol
Spaca1provided by MGI
Official Full Name
sperm acrosome associated 1provided by MGI
Primary source
MGI:MGI:1914902
See related
Ensembl:ENSMUSG00000028264 AllianceGenome:MGI:1914902
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700124L11Rik; 4930540L03Rik
Summary
Acts upstream of or within acrosome assembly. Located in acrosomal membrane. Human ortholog(s) of this gene implicated in spermatogenic failure 85. Orthologous to human SPACA1 (sperm acrosome associated 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward testis adult (RPKM 74.4) See more
Orthologs
human all
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Genomic context

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See Spaca1 in Genome Data Viewer
Location:
4 A5; 4 16.63 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (34024872..34050067, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (34024872..34050067, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33105 Neighboring gene cannabinoid receptor 1 Neighboring gene predicted gene, 25623 Neighboring gene predicted gene, 46855

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cleavage of SPACA1 regulates assembly of sperm-egg membrane fusion machinery in mature spermatozoa†. Yamatoya K, et al. Biol Reprod, 2020 Mar 13. PMID 31836887
  2. SPACA1-deficient male mice are infertile with abnormally shaped sperm heads reminiscent of globozoospermia. Fujihara Y, et al. Development, 2012 Oct. PMID 22949614
  3. Human Globozoospermia-Related Gene Spata16 Is Required for Sperm Formation Revealed by CRISPR/Cas9-Mediated Mouse Models. Fujihara Y, et al. Int J Mol Sci, 2017 Oct 21. PMID 29065458, Free PMC Article
  4. Disruption in CYLC1 leads to acrosome detachment, sperm head deformity, and male in/subfertility in humans and mice. Jin HJ, et al. Elife, 2024 Apr 4. PMID 38573307, Free PMC Article
  5. Transgenerational epigenetic effects imposed by neonicotinoid thiacloprid exposure. Dali O, et al. Life Sci Alliance, 2024 Feb. PMID 37973188, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cleavage of SPACA1 regulates assembly of sperm-egg membrane fusion machinery in mature spermatozoadagger.
    Title: Cleavage of SPACA1 regulates assembly of sperm-egg membrane fusion machinery in mature spermatozoa†.
  2. SPACA1-deficient male mice are infertile with abnormally shaped sperm heads reminiscent of globozoospermia.
    Title: SPACA1-deficient male mice are infertile with abnormally shaped sperm heads reminiscent of globozoospermia.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in acrosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within acrosome assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in acrosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in acrosomal membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in acrosomal vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in inner acrosomal membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
sperm acrosome membrane-associated protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290443.1 → NP_001277372.1  sperm acrosome membrane-associated protein 1 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 3' terminal exon, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK007270, BY450124, BY706285
    Consensus CDS
    CCDS71357.1
    UniProtKB/TrEMBL
    B1AWF1
    Related
    ENSMUSP00000081785.5, ENSMUST00000084734.11
    Conserved Domains (1) summary
    cd13783
    Location:30 → 278
    SPACA1; Sperm acrosome membrane-associated protein 1

  2. NM_026293.3 → NP_080569.1  sperm acrosome membrane-associated protein 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_080569.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AL732568
    Consensus CDS
    CCDS18026.1
    UniProtKB/Swiss-Prot
    Q9DA48
    UniProtKB/TrEMBL
    B1AWF2
    Related
    ENSMUSP00000029927.6, ENSMUST00000029927.6
    Conserved Domains (1) summary
    cd13783
    Location:30 → 285
    SPACA1; Sperm acrosome membrane-associated protein 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    34024872..34050067 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DA48.1 GenPept UniProtKB/Swiss-Prot:Q9DA48

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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