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Nudt7 nudix hydrolase 7 [ Mus musculus (house mouse) ]

Gene ID: 67528, updated on 27-Nov-2024

Summary

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Official Symbol
Nudt7provided by MGI
Official Full Name
nudix hydrolase 7provided by MGI
Primary source
MGI:MGI:1914778
See related
Ensembl:ENSMUSG00000031767 AllianceGenome:MGI:1914778
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1300007B24Rik; 2210404C19Rik
Summary
Enables coenzyme A diphosphatase activity; magnesium ion binding activity; and snoRNA binding activity. Involved in nucleoside phosphate catabolic process. Acts upstream of or within brown fat cell differentiation. Located in peroxisome. Orthologous to human NUDT7 (nudix hydrolase 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in liver adult (RPKM 27.8), subcutaneous fat pad adult (RPKM 6.0) and 7 other tissues See more
Orthologs
human all
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Genomic context

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See Nudt7 in Genome Data Viewer
Location:
8 E1; 8 60.53 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (114860314..114881471)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (114133574..114154731)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 18 Neighboring gene STARR-seq mESC enhancer starr_22763 Neighboring gene predicted gene, 30107 Neighboring gene STARR-seq mESC enhancer starr_22765 Neighboring gene STARR-positive B cell enhancer ABC_E9028 Neighboring gene STARR-seq mESC enhancer starr_22767 Neighboring gene vesicle amine transport protein 1 like Neighboring gene RIKEN cDNA 4933408N05 gene Neighboring gene predicted gene, 30330 Neighboring gene C-type lectin domain family 3, member a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. NUDT7 regulates total hepatic CoA levels and the composition of the intestinal bile acid pool in male mice fed a Western diet. Vickers SD, et al. J Biol Chem, 2023 Jan. PMID 36436558, Free PMC Article
  2. Overexpression of Nudt7 decreases bile acid levels and peroxisomal fatty acid oxidation in the liver. Shumar SA, et al. J Lipid Res, 2019 May. PMID 30846528, Free PMC Article
  3. Dysregulation of the NUDT7-PGAM1 axis is responsible for chondrocyte death during osteoarthritis pathogenesis. Song J, et al. Nat Commun, 2018 Aug 24. PMID 30143643, Free PMC Article
  4. Nudt19 is a renal CoA diphosphohydrolase with biochemical and regulatory properties that are distinct from the hepatic Nudt7 isoform. Shumar SA, et al. J Biol Chem, 2018 Mar 16. PMID 29378847, Free PMC Article
  5. The nudix hydrolase 7 is an Acyl-CoA diphosphatase involved in regulating peroxisomal coenzyme A homeostasis. Reilly SJ, et al. J Biochem, 2008 Nov. PMID 18799520

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Upregulated FOXM1 stimulates chondrocyte senescence in Acot12[-/-]Nudt7[-/-] double knockout mice.
    Title: Upregulated FOXM1 stimulates chondrocyte senescence in Acot12(-/-)Nudt7(-/-) double knockout mice.
  2. NUDT7 regulates total hepatic CoA levels and the composition of the intestinal bile acid pool in male mice fed a Western diet.
    Title: NUDT7 regulates total hepatic CoA levels and the composition of the intestinal bile acid pool in male mice fed a Western diet.
  3. The modulation of Nudt7 activity could contribute to the regulation of the peroxisomal CoA pool and peroxisomal lipid metabolism.
    Title: Overexpression of Nudt7 decreases bile acid levels and peroxisomal fatty acid oxidation in the liver.
  4. Data suggest that NUDT7alpha function is tightly linked to peroxisomal CoASH/acyl-CoA homeostasis.
    Title: The nudix hydrolase 7 is an Acyl-CoA diphosphatase involved in regulating peroxisomal coenzyme A homeostasis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
NOT enables 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables coenzyme A diphosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables coenzyme A diphosphatase activity TAS
Traceable Author Statement
more info
  
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables manganese ion binding IEA
Inferred from Electronic Annotation
more info
  
enables snoRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within acetyl-CoA catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in acetyl-CoA catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within brown fat cell differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in butyryl-CoA catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in coenzyme A catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within coenzyme A catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in coenzyme A catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in malonyl-CoA catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in medium-chain fatty-acyl-CoA catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nucleoside diphosphate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in propionyl-CoA catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in propionyl-CoA metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in succinyl-CoA catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in peroxisomal matrix TAS
Traceable Author Statement
more info
  
is_active_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
peroxisomal coenzyme A diphosphatase NUDT7
Names
coenzyme A diphosphatase
nucleoside diphosphate-linked moiety X motif 7
nudix (nucleoside diphosphate linked moiety X)-type motif 7
nudix motif 7
NP_001277110.1
NP_001277111.1
NP_001363956.1
NP_077757.2
NP_077766.3
XP_011246793.1
XP_017168434.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290181.1 → NP_001277110.1  peroxisomal coenzyme A diphosphatase NUDT7 isoform 4

    See identical proteins and their annotated locations for NP_001277110.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (4) has a distinct N-terminus and is longer than isoform 1.
    Source sequence(s)
    AC121999, AF338424, AK004924
    Consensus CDS
    CCDS80935.1
    UniProtKB/Swiss-Prot
    Q99P30
    Related
    ENSMUSP00000104737.2, ENSMUST00000109109.8
    Conserved Domains (1) summary
    cd03426
    Location:65 → 225
    CoAse; Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative ...

  2. NM_001290182.1 → NP_001277111.1  peroxisomal coenzyme A diphosphatase NUDT7 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks a 3' exon but contains an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (5) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC121999, AK008824, BC033046
    Consensus CDS
    CCDS80934.1
    UniProtKB/Swiss-Prot
    Q99P30
    Related
    ENSMUSP00000116868.2, ENSMUST00000134593.2
    Conserved Domains (1) summary
    cd03426
    Location:41 → 121
    CoAse; Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative ...

  3. NM_001377027.1 → NP_001363956.1  peroxisomal coenzyme A diphosphatase NUDT7 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC121999
    Conserved Domains (1) summary
    cd03426
    Location:41 → 114
    CoAse; Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative ...

  4. NM_024437.4 → NP_077757.2  peroxisomal coenzyme A diphosphatase NUDT7 isoform 1

    See identical proteins and their annotated locations for NP_077757.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC121999, AF338424, AK004924
    Consensus CDS
    CCDS22687.1
    UniProtKB/Swiss-Prot
    Q6IS65, Q8BU08, Q8K260, Q99P30, Q9D0Q3, Q9DBI9
    Related
    ENSMUSP00000073213.6, ENSMUST00000073521.12
    Conserved Domains (1) summary
    cd03426
    Location:41 → 201
    CoAse; Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative ...

  5. NM_024446.5 → NP_077766.3  peroxisomal coenzyme A diphosphatase NUDT7 isoform 2

    See identical proteins and their annotated locations for NP_077766.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AC121999, AF338424, AK004924, AK011172
    Consensus CDS
    CCDS22688.2
    UniProtKB/Swiss-Prot
    Q99P30
    Related
    ENSMUSP00000114598.2, ENSMUST00000147605.8
    Conserved Domains (1) summary
    cd03426
    Location:41 → 181
    CoAse; Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative ...

RNA

  1. NR_165049.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC121999
    Related
    ENSMUST00000066514.13

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    114860314..114881471
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011248491.3 → XP_011246793.1  peroxisomal coenzyme A diphosphatase NUDT7 isoform X2

    Conserved Domains (1) summary
    cd03426
    Location:65 → 138
    CoAse; Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative ...

  2. XM_017312945.1 → XP_017168434.1  peroxisomal coenzyme A diphosphatase NUDT7 isoform X1

    Conserved Domains (1) summary
    cd03426
    Location:65 → 205
    CoAse; Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001290180.1: Suppressed sequence

    Description
    NM_001290180.1: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99P30.2 GenPept UniProtKB/Swiss-Prot:Q99P30

Gene LinkOut

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