Mettl16 methyltransferase 16, N6-methyladenosine [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mettl16provided by MGI
Official Full Name: methyltransferase 16, N6-methyladenosineprovided by MGI
Primary source: MGI:MGI:1914743
See related: Ensembl:ENSMUSG00000010554 AllianceGenome:MGI:1914743
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mett10d; 2610100D03Rik; 2810013M15Rik; A830095F14Rik
Summary: Enables mRNA m(6)A methyltransferase activity. Involved in RNA metabolic process and mRNA destabilization. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and hemolymphoid system. Orthologous to human METTL16 (methyltransferase 16, RNA N6-adenosine). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 3.5), CNS E18 (RPKM 2.4) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B5; 11 45.76 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (74661658..74716649)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (74770815..74826855)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A Mettl16/m[6]A/mybl2b/Igf2bp1 axis ensures cell cycle progression of embryonic hematopoietic stem and progenitor cells.
Title: A Mettl16/m(6)A/mybl2b/Igf2bp1 axis ensures cell cycle progression of embryonic hematopoietic stem and progenitor cells.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (11) 1 citation
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

02.MMHAP26FRA8.seq (e-PCR)
- UniSTS:122700

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables RNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables RNA stem-loop binding	ISO Inferred from Sequence Orthology more info
enables RNA stem-loop binding	ISS Inferred from Sequence or Structural Similarity more info
enables U6 snRNA (adenine-(43)-N(6))-methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables U6 snRNA (adenine-(43)-N(6))-methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables U6 snRNA 3'-end binding	ISO Inferred from Sequence Orthology more info
enables U6 snRNA 3'-end binding	ISS Inferred from Sequence or Structural Similarity more info
enables mRNA m(6)A methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables mRNA m(6)A methyltransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in RNA methylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of S-adenosylmethionine biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in mRNA catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in mRNA destabilization	IDA Inferred from Direct Assay more info	PubMed
involved_in mRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA processing	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of 3'-UTR-mediated mRNA stabilization	ISO Inferred from Sequence Orthology more info
involved_in post-transcriptional regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in post-transcriptional regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in post-transcriptional regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in rRNA base methylation	IBA Inferred from Biological aspect of Ancestor more info
NOT involved_in regulation of mRNA splicing, via spliceosome	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in regulation of mRNA splicing, via spliceosome	ISS Inferred from Sequence or Structural Similarity more info
involved_in snRNA (adenine-N6)-methylation	ISO Inferred from Sequence Orthology more info
involved_in snRNA (adenine-N6)-methylation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: RNA N(6)-adenosine-methyltransferase METTL16; RNA N6-adenosine-methyltransferase METTL16

Names: N6-adenosine-methyltransferase METTL16; U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase; methyltransferase 10 domain containing; methyltransferase 10 domain-containing protein; methyltransferase like 16; methyltransferase-like protein 16; putative methyltransferase METT10D

NP_080473.1

EC 2.1.1.346

EC 2.1.1.348

XP_006534061.1

EC 2.1.1.346

EC 2.1.1.348

XP_006534062.1

EC 2.1.1.346

EC 2.1.1.348

XP_006534063.1

EC 2.1.1.346

EC 2.1.1.348

XP_006534064.1

EC 2.1.1.346

EC 2.1.1.348

XP_017170208.1

EC 2.1.1.346

EC 2.1.1.348

XP_030102109.1

EC 2.1.1.346

EC 2.1.1.348

XP_036012804.1

EC 2.1.1.346

EC 2.1.1.348

XP_036012805.1

EC 2.1.1.346

EC 2.1.1.348

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026197.3 → NP_080473.1 RNA N(6)-adenosine-methyltransferase METTL16

See identical proteins and their annotated locations for NP_080473.1

Status: PROVISIONAL

Source sequence(s)

AL604066, AL607024

Consensus CDS

CCDS25036.1

UniProtKB/Swiss-Prot

Q3UMA9, Q9CQG2, Q9D062

UniProtKB/TrEMBL

Q5SW15

Related

ENSMUSP00000114682.2, ENSMUST00000141755.8

Conserved Domains (1) summary

cl17173
Location:1 → 291

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

74661658..74716649

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036156911.1 → XP_036012804.1 RNA N6-adenosine-methyltransferase METTL16 isoform X3

Conserved Domains (1) summary

cl17173
Location:1 → 73

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
XM_006533998.5 → XP_006534061.1 RNA N6-adenosine-methyltransferase METTL16 isoform X1

See identical proteins and their annotated locations for XP_006534061.1

UniProtKB/Swiss-Prot

Q3UMA9, Q9CQG2, Q9D062

UniProtKB/TrEMBL

Q5SW15

Conserved Domains (1) summary

cl17173
Location:1 → 291

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
XM_006533999.4 → XP_006534062.1 RNA N6-adenosine-methyltransferase METTL16 isoform X1

See identical proteins and their annotated locations for XP_006534062.1

UniProtKB/Swiss-Prot

Q3UMA9, Q9CQG2, Q9D062

UniProtKB/TrEMBL

Q5SW15

Conserved Domains (1) summary

cl17173
Location:1 → 291

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
XM_017314719.3 → XP_017170208.1 RNA N6-adenosine-methyltransferase METTL16 isoform X2

UniProtKB/TrEMBL

Q5SW15

Conserved Domains (1) summary

cl17173
Location:1 → 244

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
XM_036156912.1 → XP_036012805.1 RNA N6-adenosine-methyltransferase METTL16 isoform X4

Conserved Domains (1) summary

cl17173
Location:23 → 71

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
XM_006534001.4 → XP_006534064.1 RNA N6-adenosine-methyltransferase METTL16 isoform X3

Conserved Domains (1) summary

cl17173
Location:1 → 73

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
XM_030246249.2 → XP_030102109.1 RNA N6-adenosine-methyltransferase METTL16 isoform X3

Conserved Domains (1) summary

cl17173
Location:1 → 73

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
XM_006534000.5 → XP_006534063.1 RNA N6-adenosine-methyltransferase METTL16 isoform X2

UniProtKB/TrEMBL

Q5SW15

Conserved Domains (1) summary

cl17173
Location:1 → 244

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...