C1qtnf4 C1q and tumor necrosis factor related protein 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: C1qtnf4provided by MGI
Official Full Name: C1q and tumor necrosis factor related protein 4provided by MGI
Primary source: MGI:MGI:1914695
See related: Ensembl:ENSMUSG00000040794 AllianceGenome:MGI:1914695
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Adin; CTRP4; 0710001E10Rik; 9430004J15Rik
Summary: Predicted to enable cytokine activity. Acts upstream of or within several processes, including cell surface receptor signaling pathway via STAT; protein phosphorylation; and reduction of food intake in response to dietary excess. Predicted to be active in extracellular space. Is expressed in brain and retina. Orthologous to human C1QTNF4 (C1q and TNF related 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in testis adult (RPKM 119.2), frontal lobe adult (RPKM 74.2) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 E1; 2 50.43 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (90713132..90720870)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (90882788..90890526)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

C1q/TNF-related protein 4 restores leptin sensitivity by downregulating NF-kappaB signaling and microglial activation.
Title: C1q/TNF-related protein 4 restores leptin sensitivity by downregulating NF-κB signaling and microglial activation.
C1q/TNF-related Protein 4 Induces Signal Transducer and Activator of Transcription 3 Pathway and Modulates Food Intake.
Title: C1q/TNF-related Protein 4 Induces Signal Transducer and Activator of Transcription 3 Pathway and Modulates Food Intake.
CTRP4 acts as an anti-inflammatory factor in macrophages and protects against endotoxic shock.
Title: CTRP4 acts as an anti-inflammatory factor in macrophages and protects against endotoxic shock.
These results suggest that Ctrp4 is involved in bone metabolism regulation and promotes osteoblast differentiation, which may become a potential target for future intervention in bone metabolic diseases.
Title: Ctrp4, a new adipokine, promotes the differentiation of osteoblasts.
CTRP4 plays an important role in inflammation and inflammation-associated colon tumorigenesis.
Title: Expression of the novel adipokine C1qTNF-related protein 4 (CTRP4) suppresses colitis and colitis-associated colorectal cancer in mice.
These results establish CTRP4 as a novel nutrient-responsive central regulator of food intake and energy balance.
Title: C1q/TNF-related protein 4 (CTRP4) is a unique secreted protein with two tandem C1q domains that functions in the hypothalamus to modulate food intake and body weight.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Targeted (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell surface receptor signaling pathway via STAT	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of interleukin-6 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-6-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-6-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of non-canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of non-canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within reduction of food intake in response to dietary excess	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: complement C1q tumor necrosis factor-related protein 4

Names: C1q/TNF-related protein 4; adiponectin n

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026161.3 → NP_080437.2 complement C1q tumor necrosis factor-related protein 4 precursor

Status: VALIDATED

Source sequence(s)

AK029777, BF458176, CX243534, DQ002397

Consensus CDS

CCDS16417.2

UniProtKB/Swiss-Prot

A2AFW1, Q4ZJN5, Q8R066, Q9D0W2, Q9DCB6

UniProtKB/TrEMBL

A0A3B0IP17

Related

ENSMUSP00000107091.3, ENSMUST00000111466.3

Conserved Domains (1) summary

pfam00386
Location:30 → 155

C1q; C1q domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

90713132..90720870

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030251995.1 → XP_030107855.1 complement C1q tumor necrosis factor-related protein 4 isoform X1

UniProtKB/Swiss-Prot

A2AFW1, Q4ZJN5, Q8R066, Q9D0W2, Q9DCB6

UniProtKB/TrEMBL

A0A3B0IP17

Conserved Domains (1) summary

pfam00386
Location:30 → 155

C1q; C1q domain
XM_006500080.4 → XP_006500143.1 complement C1q tumor necrosis factor-related protein 4 isoform X1

UniProtKB/Swiss-Prot

A2AFW1, Q4ZJN5, Q8R066, Q9D0W2, Q9DCB6

UniProtKB/TrEMBL

A0A3B0IP17

Conserved Domains (1) summary

pfam00386
Location:30 → 155

C1q; C1q domain
XM_006500079.2 → XP_006500142.1 complement C1q tumor necrosis factor-related protein 4 isoform X1

UniProtKB/Swiss-Prot

A2AFW1, Q4ZJN5, Q8R066, Q9D0W2, Q9DCB6

UniProtKB/TrEMBL

A0A3B0IP17

Conserved Domains (1) summary

pfam00386
Location:30 → 155

C1q; C1q domain
XM_030251994.2 → XP_030107854.1 complement C1q tumor necrosis factor-related protein 4 isoform X1

UniProtKB/Swiss-Prot

A2AFW1, Q4ZJN5, Q8R066, Q9D0W2, Q9DCB6

UniProtKB/TrEMBL

A0A3B0IP17

Conserved Domains (1) summary

pfam00386
Location:30 → 155

C1q; C1q domain