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Ppil4 peptidylprolyl isomerase (cyclophilin)-like 4 [ Mus musculus (house mouse) ]

Gene ID: 67418, updated on 27-Nov-2024

Summary

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Official Symbol
Ppil4provided by MGI
Official Full Name
peptidylprolyl isomerase (cyclophilin)-like 4provided by MGI
Primary source
MGI:MGI:1914668
See related
Ensembl:ENSMUSG00000015757 AllianceGenome:MGI:1914668
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PPIase; 3732410E19Rik; 3830425H19Rik
Summary
Predicted to enable RNA binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein peptidyl-prolyl isomerization. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Is expressed in central nervous system and sensory organ. Orthologous to human PPIL4 (peptidylprolyl isomerase like 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 10.7), CNS E14 (RPKM 9.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ppil4 in Genome Data Viewer
Location:
10 A1; 10 2.38 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (7668653..7698329)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (7792889..7822565)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6817 Neighboring gene katanin p60 (ATPase-containing) subunit A1 Neighboring gene STARR-positive B cell enhancer ABC_E9338 Neighboring gene glycoprotein integral membrane 1 Neighboring gene STARR-positive B cell enhancer mm9_chr10:7529819-7530120 Neighboring gene STARR-positive B cell enhancer ABC_E5118 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:7559346-7559529 Neighboring gene zinc finger CCCH type containing 12D Neighboring gene microRNA 5104 Neighboring gene predicted gene, 24726

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Molecular cloning, structure and expression of a novel nuclear RNA-binding cyclophilin-like gene (PPIL4) from human fetal brain. Zeng L, et al. Cytogenet Cell Genet, 2001. PMID 11978968
  2. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. McKee AE, et al. BMC Dev Biol, 2005 Jul 20. PMID 16033648, Free PMC Article
  3. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
  4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II CTD heptapeptide repeat P3 isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II CTD heptapeptide repeat P6 isomerase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
peptidyl-prolyl cis-trans isomerase-like 4
Names
cyclophilin-like protein PPIL4
rotamase PPIL4
NP_080417.2
XP_006512895.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001429484.1 → NP_001416413.1  peptidyl-prolyl cis-trans isomerase-like 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC159137

  2. NM_026141.4 → NP_080417.2  peptidyl-prolyl cis-trans isomerase-like 4 isoform 1

    See identical proteins and their annotated locations for NP_080417.2

    Status: VALIDATED

    Source sequence(s)
    AC159137
    Consensus CDS
    CCDS23690.1
    UniProtKB/Swiss-Prot
    Q3TJX1, Q68FC7, Q9CT22, Q9CXG3
    UniProtKB/TrEMBL
    Q9D3J1
    Related
    ENSMUSP00000015901.5, ENSMUST00000015901.11
    Conserved Domains (3) summary
    COG0724
    Location:193 → 320
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd01921
    Location:4 → 161
    cyclophilin_RRM; cyclophilin_RRM: cyclophilin-type peptidylprolyl cis- trans isomerase domain occuring with a C-terminal RNA recognition motif domain (RRM). This subfamily of the cyclophilin domain family contains a number of eukaryotic cyclophilins having the RRM domain ...
    cd12235
    Location:237 → 319
    RRM_PPIL4; RNA recognition motif in peptidyl-prolyl cis-trans isomerase-like 4 (PPIase) and similar proteins

RNA

  1. NR_190739.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC159137

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    7668653..7698329
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512832.5 → XP_006512895.1  peptidyl-prolyl cis-trans isomerase-like 4 isoform X1

    Conserved Domains (2) summary
    cd01921
    Location:4 → 161
    cyclophilin_RRM; cyclophilin-type peptidylprolyl cis- trans isomerase domain occuring with a C-terminal RNA recognition motif domain (RRM). This subfamily of the cyclophilin domain family contains a number of eukaryotic cyclophilins having the RRM domain including the ...
    cd12235
    Location:237 → 319
    RRM_PPIL4; RNA recognition motif in peptidyl-prolyl cis-trans isomerase-like 4 (PPIase) and similar proteins

RNA

  1. XR_004936262.1 RNA Sequence

  2. XR_004936263.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CXG3.2 GenPept UniProtKB/Swiss-Prot:Q9CXG3

Gene LinkOut

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