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SRP9 signal recognition particle 9 [ Homo sapiens (human) ]

Gene ID: 6726, updated on 27-Nov-2024

Summary

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Official Symbol
SRP9provided by HGNC
Official Full Name
signal recognition particle 9provided by HGNC
Primary source
HGNC:HGNC:11304
See related
Ensembl:ENSG00000143742 MIM:600707; AllianceGenome:HGNC:11304
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ALURBP
Summary
Predicted to enable RNA binding activity and signal recognition particle binding activity. Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane. Predicted to be located in cytosol. Predicted to be part of signal recognition particle, endoplasmic reticulum targeting. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in adrenal (RPKM 131.7), brain (RPKM 102.1) and 25 other tissues See more
Orthologs
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Genomic context

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See SRP9 in Genome Data Viewer
Location:
1q42.12
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (225777826..225790464)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (224965843..224978462)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (225965528..225978166)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985352 Neighboring gene RNA, U6 small nuclear 1304, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:225938191-225938690 Neighboring gene uncharacterized LOC124904527 Neighboring gene VISTA enhancer hs2374 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:225956009-225956180 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_5770 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:225964521-225965281 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2629 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:225969251-225969750 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1859 Neighboring gene left-right determination factor 3, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:226004679-226005506 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:226005507-226006333 Neighboring gene epoxide hydrolase 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:226012583-226013259 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:226015269-226016122 Neighboring gene transmembrane protein 63A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Significance of signal recognition particle 9 nuclear translocation: Implications for pancreatic cancer prognosis and functionality. Sato H, et al. Int J Oncol, 2024 Jul. PMID 38847231, Free PMC Article
  2. Human signal recognition particle (SRP) Alu-associated protein also binds Alu interspersed repeat sequence RNAs. Characterization of human SRP9. Hsu K, et al. J Biol Chem, 1995 Apr 28. PMID 7730321
  3. Compartmentalization directs assembly of the signal recognition particle. Maity TS, et al. Biochemistry, 2006 Dec 19. PMID 17154533
  4. Investigation of SRP9 protein expression in breast cancer. Erdoğan G, et al. Mol Biol Rep, 2022 Jan. PMID 34727289
  5. Assembly of the Alu domain of the signal recognition particle (SRP): dimerization of the two protein components is required for efficient binding to SRP RNA. Strub K, et al. Mol Cell Biol, 1990 Feb. PMID 2153922, Free PMC Article

See all (124) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Significance of signal recognition particle 9 nuclear translocation: Implications for pancreatic cancer prognosis and functionality.
    Title: Significance of signal recognition particle 9 nuclear translocation: Implications for pancreatic cancer prognosis and functionality.
  2. Investigation of SRP9 protein expression in breast cancer.
    Title: Investigation of SRP9 protein expression in breast cancer.
  3. Dats show that Alu RNA promotes functional binding of Signal Recognition Particle proteins SRP9/14 to 40S ribosomal subunits.
    Title: Alu RNA regulates the cellular pool of active ribosomes by targeted delivery of SRP9/14 to 40S subunits.
  4. mutational study on SRP9/14 that identified and characterized regions and single residues essential for elongation arrest activity
    Title: Residues in SRP9/14 essential for elongation arrest activity of the signal recognition particle define a positively charged functional domain on one side of the protein.
  5. PSB7, PRDX1, and SRP9 up-regulation as candidate biomarkers of colon cancer is discovered
    Title: Proteomic expression analysis of surgical human colorectal cancer tissues: up-regulation of PSB7, PRDX1, and SRP9 and hypoxic adaptation in cancer.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Downregulation of guanine nucleotide-releasing protein, CD151/PETA-3, neuronatin, neuroendocrine differentiation factor, mitochondria 16s rRNA, and signal recognition particle is observed in HIV-1 infected and HIV-1 gp120-treated astrocytes PubMed
Rev rev HIV-1 Rev interacting protein, signal recognition particle 9kDa (SRP9), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with SRP9 is increased by RRE PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC110981

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 7S RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signal recognition particle binding TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in SRP-dependent cotranslational protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of translational elongation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of signal recognition particle receptor complex TAS
Traceable Author Statement
more info
 PubMed 
part_of signal recognition particle, endoplasmic reticulum targeting IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of signal recognition particle, endoplasmic reticulum targeting NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
signal recognition particle 9 kDa protein
Names
signal recognition particle 9kD
signal recognition particle 9kDa
NP_001123912.1
NP_003124.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130440.2 → NP_001123912.1  signal recognition particle 9 kDa protein isoform 1

    See identical proteins and their annotated locations for NP_001123912.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the longer transcript but encodes the shorter isoform (1).
    Source sequence(s)
    BC021995, DA983529, EF488978
    Consensus CDS
    CCDS44323.1
    Related
    ENSP00000355804.4, ENST00000366839.8
    Conserved Domains (1) summary
    pfam05486
    Location:4 → 51
    SRP9-21; Signal recognition particle 9 kDa protein (SRP9)

  2. NM_003133.6 → NP_003124.1  signal recognition particle 9 kDa protein isoform 2

    See identical proteins and their annotated locations for NP_003124.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an internal exon, as compared to variant 1. The resulting isoform (2) has a longer and distinct C-terminus, as compared to isoform 1.
    Source sequence(s)
    BC008443, BC021995, DA983529
    Consensus CDS
    CCDS1546.1
    UniProtKB/Swiss-Prot
    A8K0N0, P49458, Q6NVX0, Q8WTW0
    Related
    ENSP00000305230.7, ENST00000304786.12
    Conserved Domains (1) summary
    pfam05486
    Location:4 → 73
    SRP9-21; Signal recognition particle 9 kDa protein (SRP9)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    225777826..225790464
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    224965843..224978462
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P49458.2 GenPept UniProtKB/Swiss-Prot:P49458

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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