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H60c histocompatibility 60c [ Mus musculus (house mouse) ]

Gene ID: 670558, updated on 27-Nov-2024

Summary

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Official Symbol
H60cprovided by MGI
Official Full Name
histocompatibility 60cprovided by MGI
Primary source
MGI:MGI:3774845
See related
Ensembl:ENSMUSG00000091618 AllianceGenome:MGI:3774845
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm9491; 4632413I24Rik
Summary
Enables natural killer cell lectin-like receptor binding activity. Acts upstream of or within natural killer cell mediated cytotoxicity. Located in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in bladder adult (RPKM 2.8), limb E14.5 (RPKM 0.8) and 5 other tissues See more
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Genomic context

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See H60c in Genome Data Viewer
Location:
10 A1; 10 2.08 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (3206202..3218091, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (3256202..3268091, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_25677 Neighboring gene predicted gene, 51789 Neighboring gene predicted gene 6667 Neighboring gene predicted gene, 29826 Neighboring gene ribosomal protein L35a pseudogene Neighboring gene STARR-seq mESC enhancer starr_25675 Neighboring gene ring finger and WD repeat domain 2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Involvement of an NKG2D ligand H60c in epidermal dendritic T cell-mediated wound repair. Yoshida S, et al. J Immunol, 2012 Apr 15. PMID 22403443
  2. Gut microbiota regulates NKG2D ligand expression on intestinal epithelial cells. Hansen CH, et al. Eur J Immunol, 2013 Feb. PMID 23136011
  3. Two novel NKG2D ligands of the mouse H60 family with differential expression patterns and binding affinities to NKG2D. Takada A, et al. J Immunol, 2008 Feb 1. PMID 18209064
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. a more general role for H60c in the maintenance of epithelial integrity.
    Title: Involvement of an NKG2D ligand H60c in epidermal dendritic T cell-mediated wound repair.
  2. Identified two novel mouse chromosome 10-encoded NKG2D ligands, H60b and H60c, structurally resembling H60.
    Title: Two novel NKG2D ligands of the mouse H60 family with differential expression patterns and binding affinities to NKG2D.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables natural killer cell lectin-like receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class Ib IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within natural killer cell mediated cytotoxicity IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in positive regulation of T cell mediated cytotoxicity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
histocompatibility antigen 60c

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204916.2 → NP_001191845.1  histocompatibility antigen 60c precursor

    See identical proteins and their annotated locations for NP_001191845.1

    Status: VALIDATED

    Source sequence(s)
    AB284506, AC157021, AK014573
    Consensus CDS
    CCDS56668.1
    UniProtKB/Swiss-Prot
    B1B213
    UniProtKB/TrEMBL
    A0A1L1SRI2
    Related
    ENSMUSP00000126536.3, ENSMUST00000170893.3
    Conserved Domains (1) summary
    cl08246
    Location:16 → 133
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    3206202..3218091 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245226.1 → XP_030101086.1  histocompatibility antigen 60c isoform X3

    Conserved Domains (1) summary
    cl08246
    Location:99 → 216
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

  2. XM_030245225.1 → XP_030101085.1  histocompatibility antigen 60c isoform X2

    UniProtKB/TrEMBL
    A0A1L1SRI2
    Related
    ENSMUSP00000149470.2, ENSMUST00000216211.2
    Conserved Domains (1) summary
    cl08246
    Location:98 → 215
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

  3. XM_006512485.4 → XP_006512548.1  histocompatibility antigen 60c isoform X1

    UniProtKB/TrEMBL
    A0A1L1SRI2
    Conserved Domains (1) summary
    cl08246
    Location:99 → 216
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B1B213.1 GenPept UniProtKB/Swiss-Prot:B1B213

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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