Nhlrc2 NHL repeat containing 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nhlrc2provided by MGI
Official Full Name: NHL repeat containing 2provided by MGI
Primary source: MGI:MGI:1914116
See related: Ensembl:ENSMUSG00000025078 AllianceGenome:MGI:1914116
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1200003G01Rik
Summary: Predicted to be located in cytosol. Is expressed in several structures, including central nervous system; cranial nerve; egg cylinder; embryo endoderm; and incisor. Orthologous to human NHLRC2 (NHL repeat containing 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in lung adult (RPKM 10.3), colon adult (RPKM 4.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 D2; 19 51.89 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (56536682..56591935)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (56548250..56603503)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nhlrc2 is crucial during mouse gastrulation.
Title: Nhlrc2 is crucial during mouse gastrulation.
Variant in NHLRC2 leads to increased hnRNP C2 in developing neurons and the hippocampus of a mouse model of FINCA disease.
Title: Variant in NHLRC2 leads to increased hnRNP C2 in developing neurons and the hippocampus of a mouse model of FINCA disease.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Gene trapped (1)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI835049 (e-PCR)
- UniSTS:166164

AV002846 (e-PCR)
- UniSTS:166165

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: NHL repeat-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025811.3 → NP_080087.1 NHL repeat-containing protein 2

See identical proteins and their annotated locations for NP_080087.1

Status: PROVISIONAL

Source sequence(s)

AC116849, AC166746

Consensus CDS

CCDS29918.1

UniProtKB/Swiss-Prot

Q80XU0, Q8BZW8

UniProtKB/TrEMBL

B2RR26, Q9CW64

Related

ENSMUSP00000071370.6, ENSMUST00000071423.7

Conserved Domains (4) summary

cd03012
Location:55 → 182

TlpA_like_DipZ_like; TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA ...

cd05819
Location:163 → 208

NHL; NHL repeat [structural motif]

cd14951
Location:261 → 623

NHL-2_like; NHL repeat domain of NHL repeat-containing protein 2 and similar proteins

cl18310
Location:163 → 296

NHL; NHL repeat unit of beta-propeller proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

56536682..56591935

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006527267.5 → XP_006527330.1 NHL repeat-containing protein 2 isoform X1

UniProtKB/TrEMBL

Q8C1S8

Conserved Domains (1) summary

cd14951
Location:14 → 371

NHL-2_like; NHL repeat domain of NHL repeat-containing protein 2 and similar proteins