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Fignl2 fidgetin-like 2 [ Mus musculus (house mouse) ]

Gene ID: 668225, updated on 9-Dec-2024

Summary

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Official Symbol
Fignl2provided by MGI
Official Full Name
fidgetin-like 2provided by MGI
Primary source
MGI:MGI:3646919
See related
Ensembl:ENSMUSG00000095440 AllianceGenome:MGI:3646919
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EG668225
Summary
Predicted to enable ATP hydrolysis activity and microtubule severing ATPase activity. Predicted to be involved in microtubule severing and negative regulation of cell migration. Predicted to be located in cell leading edge. Orthologous to human FIGNL2 (fidgetin like 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Broad expression in ovary adult (RPKM 6.5), adrenal adult (RPKM 5.8) and 23 other tissues See more
Orthologs
human all
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Genomic context

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See Fignl2 in Genome Data Viewer
Location:
15 F1; 15 56.39 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (100948075..100976465, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (101050192..101078584, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene sodium channel, voltage-gated, type VIII, alpha Neighboring gene predicted gene, 52176 Neighboring gene STARR-seq mESC enhancer starr_39769 Neighboring gene transmembrane and death domain 1 Neighboring gene predicted gene, 53912 Neighboring gene predicted gene, 41402 Neighboring gene ankyrin repeat domain 33

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Fidgetin-like 2 negatively regulates axonal growth and can be targeted to promote functional nerve regeneration. Baker L, et al. JCI Insight, 2021 May 10. PMID 33872220, Free PMC Article
  2. Fidgetin-Like 2: A Microtubule-Based Regulator of Wound Healing. Charafeddine RA, et al. J Invest Dermatol, 2015 Sep. PMID 25756798, Free PMC Article
  3. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. The transcriptional landscape of the mammalian genome. Carninci P, et al. Science, 2005 Sep 2. PMID 16141072

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Fidgetin-like 2 negatively regulates axonal growth and can be targeted to promote functional nerve regeneration.
    Title: Fidgetin-like 2 negatively regulates axonal growth and can be targeted to promote functional nerve regeneration.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule severing ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in microtubule severing ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell leading edge ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
fidgetin-like protein 2
NP_001201840.1
XP_006521346.1
XP_006521347.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001214911.3 → NP_001201840.1  fidgetin-like protein 2

    See identical proteins and their annotated locations for NP_001201840.1

    Status: VALIDATED

    Source sequence(s)
    AC104834
    Consensus CDS
    CCDS57012.1
    UniProtKB/Swiss-Prot
    J3QK54
    Related
    ENSMUSP00000150618.2, ENSMUST00000213610.2
    Conserved Domains (1) summary
    COG0464
    Location:381 → 638
    SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    100948075..100976465 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521284.1 → XP_006521347.1  fidgetin-like protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006521347.1

    UniProtKB/Swiss-Prot
    J3QK54
    Conserved Domains (1) summary
    COG0464
    Location:381 → 638
    SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]

  2. XM_006521283.1 → XP_006521346.1  fidgetin-like protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006521346.1

    UniProtKB/Swiss-Prot
    J3QK54
    Related
    ENSMUSP00000137256.2, ENSMUST00000178140.2
    Conserved Domains (1) summary
    COG0464
    Location:381 → 638
    SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_028577.1: Suppressed sequence

    Description
    NG_028577.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
J3QK54.1 GenPept UniProtKB/Swiss-Prot:J3QK54

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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