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Plaat5 phospholipase A and acyltransferase 5 [ Mus musculus (house mouse) ]

Gene ID: 66727, updated on 27-Nov-2024

Summary

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Official Symbol
Plaat5provided by MGI
Official Full Name
phospholipase A and acyltransferase 5provided by MGI
Primary source
MGI:MGI:1913977
See related
Ensembl:ENSMUSG00000024973 AllianceGenome:MGI:1913977
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
iNAT; HRSL5; Hrasls5; 1700055A14Rik; 1700086E08Rik; 4921526K24Rik
Summary
Enables N-acyltransferase activity. Acts upstream of or within N-acylphosphatidylethanolamine metabolic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human PLAAT5 (phospholipase A and acyltransferase 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward testis adult (RPKM 836.0) See more
Orthologs
human all
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Genomic context

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See Plaat5 in Genome Data Viewer
Location:
19 A; 19 5.33 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (7589902..7618405)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (7612537..7641040)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene phospholipase A and acyltransferase 3 Neighboring gene STARR-seq mESC enhancer starr_45469 Neighboring gene STARR-seq mESC enhancer starr_45470 Neighboring gene lectin, galactose binding, soluble 12 Neighboring gene IscU iron-sulfur cluster scaffold homolog pseudogene Neighboring gene solute carrier family 22 (organic anion transporter), member 19 Neighboring gene Yamaguchi sarcoma viral (v-yes) oncogene homolog 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. cDNA cloning and characterization of human and mouse Ca(2+)-independent phosphatidylethanolamine N-acyltransferases. Jin XH, et al. Biochim Biophys Acta, 2009 Jan. PMID 19000777
  2. Discovery and characterization of a Ca2+-independent phosphatidylethanolamine N-acyltransferase generating the anandamide precursor and its congeners. Jin XH, et al. J Biol Chem, 2007 Feb 9. PMID 17158102
  3. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables N-acyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables N-acyltransferase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables calcium-dependent phospholipase A2 activity IEA
Inferred from Electronic Annotation
more info
  
enables calcium-independent phospholipase A2 activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylserine 1-acylhydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables phospholipase A1 activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phospholipase A1 activity ISO
Inferred from Sequence Orthology
more info
  
enables phospholipase A1 activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phospholipase A2 activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phospholipase A2 activity ISO
Inferred from Sequence Orthology
more info
  
enables phospholipase A2 activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in N-acylphosphatidylethanolamine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within N-acylphosphatidylethanolamine metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within N-acylphosphatidylethanolamine metabolic process ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in N-acylphosphatidylethanolamine metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
phospholipase A and acyltransferase 5
Names
Ca(2+)-independent N-acyltransferase
Ca-independent N-acyltransferase
H-rev107-like protein 5
HRAS-like suppressor 5
HRAS-like suppressor family, member 5
NP_001355625.1
NP_080007.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368696.1 → NP_001355625.1  phospholipase A and acyltransferase 5 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC109225, AK006790
    UniProtKB/TrEMBL
    D3YZK9
    Related
    ENSMUSP00000118096.3, ENSMUST00000148558.3
    Conserved Domains (1) summary
    pfam04970
    Location:134 → 236
    LRAT; Lecithin retinol acyltransferase

  2. NM_025731.3 → NP_080007.2  phospholipase A and acyltransferase 5 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC109225, AK014971
    Consensus CDS
    CCDS29530.1
    UniProtKB/Swiss-Prot
    Q6P8Y6, Q9CPX5, Q9CVQ2, Q9CVS0
    Related
    ENSMUSP00000025929.6, ENSMUST00000025929.12
    Conserved Domains (1) summary
    pfam04970
    Location:134 → 236
    LRAT; Lecithin retinol acyltransferase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    7589902..7618405
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CPX5.2 GenPept UniProtKB/Swiss-Prot:Q9CPX5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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