U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Hspbap1 Hspb associated protein 1 [ Mus musculus (house mouse) ]

Gene ID: 66667, updated on 27-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Hspbap1provided by MGI
Official Full Name
Hspb associated protein 1provided by MGI
Primary source
MGI:MGI:1913917
See related
Ensembl:ENSMUSG00000022849 AllianceGenome:MGI:1913917
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
3830421G21Rik
Summary
Predicted to enable 2-oxoglutarate-dependent dioxygenase activity. Predicted to be located in cytoplasm. Is expressed in early conceptus; genitourinary system; gut gland; and trachea. Orthologous to human HSPBAP1 (HSPB1 associated protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in placenta adult (RPKM 4.4), liver E14 (RPKM 2.7) and 27 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Hspbap1 in Genome Data Viewer
Location:
16 B3; 16 25.43 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (35590009..35648832)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (35769726..35828462)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B Neighboring gene VISTA enhancer mm1471 Neighboring gene 40S ribosomal protein S21 pseudogene Neighboring gene solute carrier family 49 member 4 Neighboring gene predicted gene, 25967 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:35747524-35747731 Neighboring gene STARR-seq mESC enhancer starr_40745 Neighboring gene STARR-positive B cell enhancer mm9_chr16:35817422-35817723 Neighboring gene STARR-seq mESC enhancer starr_40746 Neighboring gene predicted gene, 26838 Neighboring gene STARR-seq mESC enhancer starr_40747 Neighboring gene poly (ADP-ribose) polymerase family, member 14 Neighboring gene predicted gene, 41467

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox Gene Temporal Collinear Activation for Body Axial Patterning in Mice. Zhang F, et al. Front Cell Dev Biol, 2021. PMID 34368113, Free PMC Article
  2. Systematic identification of factors for provirus silencing in embryonic stem cells. Yang BX, et al. Cell, 2015 Sep 24. PMID 26365490, Free PMC Article
  3. Tagging genes with cassette-exchange sites. Cobellis G, et al. Nucleic Acids Res, 2005 Mar 1. PMID 15741177, Free PMC Article
  4. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
  5. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 2-oxoglutarate-dependent dioxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
HSPB1-associated protein 1
Names
27 KdA heat shock protein-associated protein 1
protein associated with small stress protein 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175111.3 → NP_780320.2  HSPB1-associated protein 1

    See identical proteins and their annotated locations for NP_780320.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the functional protein.
    Source sequence(s)
    AA879889, AK028824, AK038142, AK076189
    Consensus CDS
    CCDS28142.1
    UniProtKB/Swiss-Prot
    E9QML8, Q8BK58
    Related
    ENSMUSP00000156217.2, ENSMUST00000231579.2
    Conserved Domains (1) summary
    pfam13621
    Location:37 → 272
    Cupin_8; Cupin-like domain

RNA

  1. NR_152314.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC129574
    Related
    ENSMUST00000023555.6

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    35590009..35648832
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006522472.5 → XP_006522535.1  HSPB1-associated protein 1 isoform X5

  2. XM_030249244.2 → XP_030105104.1  HSPB1-associated protein 1 isoform X6

    UniProtKB/TrEMBL
    A0A384DV63
    Conserved Domains (1) summary
    smart00558
    Location:150 → 189
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily

  3. XM_006522471.5 → XP_006522534.1  HSPB1-associated protein 1 isoform X3

    Conserved Domains (1) summary
    pfam13621
    Location:37 → 273
    Cupin_8; Cupin-like domain

  4. XM_006522469.5 → XP_006522532.1  HSPB1-associated protein 1 isoform X1

    Conserved Domains (1) summary
    pfam13621
    Location:37 → 296
    Cupin_8; Cupin-like domain

  5. XM_006522470.4 → XP_006522533.1  HSPB1-associated protein 1 isoform X2

    Conserved Domains (1) summary
    pfam13621
    Location:37 → 295
    Cupin_8; Cupin-like domain

  6. XM_030249243.2 → XP_030105103.1  HSPB1-associated protein 1 isoform X4

    Conserved Domains (1) summary
    cl21464
    Location:2 → 33
    cupin_like; Conserved domain found in cupin and related proteins

  7. XM_030249242.2 → XP_030105102.1  HSPB1-associated protein 1 isoform X4

    Conserved Domains (1) summary
    cl21464
    Location:2 → 33
    cupin_like; Conserved domain found in cupin and related proteins

  8. XM_030249241.2 → XP_030105101.1  HSPB1-associated protein 1 isoform X4

    Conserved Domains (1) summary
    cl21464
    Location:2 → 33
    cupin_like; Conserved domain found in cupin and related proteins

  9. XM_017317116.2 → XP_017172605.1  HSPB1-associated protein 1 isoform X4

    Conserved Domains (1) summary
    cl21464
    Location:2 → 33
    cupin_like; Conserved domain found in cupin and related proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BK58.2 GenPept UniProtKB/Swiss-Prot:Q8BK58

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools