Ctrb1 chymotrypsinogen B1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ctrb1provided by MGI
Official Full Name: chymotrypsinogen B1provided by MGI
Primary source: MGI:MGI:88559
See related: Ensembl:ENSMUSG00000031957 AllianceGenome:MGI:88559
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ctrb; Prt-2; 2200008D09Rik
Summary: Enables serine-type endopeptidase activity. Acts upstream of or within proteolysis. Predicted to be located in extracellular region. Is expressed in ovary; pancreas; pancreas tip epithelium; and testis. Orthologous to human CTRB1 (chymotrypsinogen B1) and CTRB2 (chymotrypsinogen B2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in small intestine adult (RPKM 13295.7), spleen adult (RPKM 12146.0) and 2 other tissues See more
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Genomic context

Location:: 8 E1; 8 57.98 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (112413142..112417642, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (111686510..111691010, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Secretagogue-induced pancreatitis in mice devoid of chymotrypsin.
Title: Secretagogue-induced pancreatitis in mice devoid of chymotrypsin.
CTRB1 protects against secretagogue-induced pancreatitis by reducing trypsin activity.
Title: Chymotrypsin Reduces the Severity of Secretagogue-Induced Pancreatitis in Mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Gene trapped (1)

General gene information

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Markers

Ctrb1 (e-PCR), detects polymorphism
- UniSTS:498500

AI504462 (e-PCR)
- UniSTS:164190

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables peptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables serine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables serine-type peptidase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in digestion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proteolysis	IDA Inferred from Direct Assay more info	PubMed
involved_in response to cytokine	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: chymotrypsinogen B

NP_079859.2

EC 3.4.21.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025583.2 → NP_079859.2 chymotrypsinogen B precursor

See identical proteins and their annotated locations for NP_079859.2

Status: VALIDATED

Source sequence(s)

AC122364, AK007815

Consensus CDS

CCDS22679.1

UniProtKB/Swiss-Prot

Q9CR35, Q9D8X8, Q9DC86

Related

ENSMUSP00000034435.6, ENSMUST00000034435.7

Conserved Domains (2) summary

smart00020
Location:33 → 256

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:34 → 259

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...