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Ergic3 ERGIC and golgi 3 [ Mus musculus (house mouse) ]

Gene ID: 66366, updated on 27-Nov-2024

Summary

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Official Symbol
Ergic3provided by MGI
Official Full Name
ERGIC and golgi 3provided by MGI
Primary source
MGI:MGI:1913616
See related
Ensembl:ENSMUSG00000005881 AllianceGenome:MGI:1913616
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CGI-54; D2Ucla1; NY-BR-84; Sdbcag84; 2310015B14Rik
Summary
Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport; positive regulation of intracellular protein transport; and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Predicted to be located in endoplasmic reticulum-Golgi intermediate compartment. Predicted to be part of retrograde transporter complex, Golgi to ER. Predicted to be active in COPII-coated ER to Golgi transport vesicle; Golgi membrane; and endoplasmic reticulum membrane. Is expressed in cerebellum; neocortex; and spleen. Orthologous to human ERGIC3 (ERGIC and golgi 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis adult (RPKM 128.8), ovary adult (RPKM 102.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ergic3 in Genome Data Viewer
Location:
2 H1; 2 77.32 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (155849948..155860199)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (156008028..156018279)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene growth differentiation factor 5 Neighboring gene STARR-seq mESC enhancer starr_06152 Neighboring gene centrosomal protein 250 Neighboring gene predicted gene, 50621 Neighboring gene RIKEN cDNA 6430550D23 gene Neighboring gene STARR-positive B cell enhancer ABC_E9074 Neighboring gene fer-1 like family member 4 Neighboring gene AE binding protein 2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mammalian Erv46 localizes to the endoplasmic reticulum-Golgi intermediate compartment and to cis-Golgi cisternae. Orci L, et al. Proc Natl Acad Sci U S A, 2003 Apr 15. PMID 12663859, Free PMC Article
  2. ERGIC2 and ERGIC3 regulate the ER-to-Golgi transport of gap junction proteins in metazoans. Guan L, et al. Traffic, 2022 Mar. PMID 34994051
  3. Mapping of three members of the mouse protein disulfide isomerase family. Briquet-Laugier V, et al. Mamm Genome, 1998 Feb. PMID 9457688
  4. A novel family of Cys-Cys, His-Cys zinc finger transcription factors expressed in developing nervous system and pituitary gland. Jiang Y, et al. J Biol Chem, 1996 May 3. PMID 8631881
  5. Altered gene expression pattern in the fatty liver dystrophy mouse reveals impaired insulin-mediated cytoskeleton dynamics. Klingenspor M, et al. J Biol Chem, 1999 Aug 13. PMID 10438476

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ERGIC2 and ERGIC3 regulate the ER-to-Golgi transport of gap junction proteins in metazoans.
    Title: ERGIC2 and ERGIC3 regulate the ER-to-Golgi transport of gap junction proteins in metazoans.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp547A2190

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of intracellular protein transport ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of intracellular protein transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in COPII-coated ER to Golgi transport vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum-Golgi intermediate compartment ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum-Golgi intermediate compartment membrane IEA
Inferred from Electronic Annotation
more info
  
part_of retrograde transporter complex, Golgi to ER IEA
Inferred from Electronic Annotation
more info
  
part_of retrograde transporter complex, Golgi to ER ISO
Inferred from Sequence Orthology
more info
  
part_of transporter complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
endoplasmic reticulum-Golgi intermediate compartment protein 3
Names
serologically defined breast cancer antigen 84
serologically defined breast cancer antigen NY-BR-84 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356413.1 → NP_001343342.1  endoplasmic reticulum-Golgi intermediate compartment protein 3 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    BC057130, DV662805
    Consensus CDS
    CCDS89572.1
    Related
    ENSMUSP00000086025.5, ENSMUST00000088650.11
    Conserved Domains (2) summary
    pfam07970
    Location:145 → 374
    COPIIcoated_ERV; Endoplasmic reticulum vesicle transporter
    pfam13850
    Location:7 → 93
    ERGIC_N; Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)

  2. NM_001356414.1 → NP_001343343.1  endoplasmic reticulum-Golgi intermediate compartment protein 3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AL833786
    Conserved Domains (2) summary
    pfam07970
    Location:145 → 368
    COPIIcoated_ERV; Endoplasmic reticulum vesicle transporter
    pfam13850
    Location:7 → 97
    ERGIC_N; Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)

  3. NM_025516.5 → NP_079792.1  endoplasmic reticulum-Golgi intermediate compartment protein 3 isoform 3

    See identical proteins and their annotated locations for NP_079792.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon and uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AI837012, AK050285, AL833786, DV662805
    Consensus CDS
    CCDS16959.1
    UniProtKB/Swiss-Prot
    B7ZCN9, Q6PGA7, Q9CQE7
    Related
    ENSMUSP00000006035.7, ENSMUST00000006035.13
    Conserved Domains (2) summary
    pfam07970
    Location:145 → 363
    COPIIcoated_ERV; Endoplasmic reticulum vesicle transporter
    pfam13850
    Location:7 → 97
    ERGIC_N; Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    155849948..155860199
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CQE7.1 GenPept UniProtKB/Swiss-Prot:Q9CQE7

Gene LinkOut

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