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Dnajc5b DnaJ heat shock protein family (Hsp40) member C5 beta [ Mus musculus (house mouse) ]

Gene ID: 66326, updated on 27-Nov-2024

Summary

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Official Symbol
Dnajc5bprovided by MGI
Official Full Name
DnaJ heat shock protein family (Hsp40) member C5 betaprovided by MGI
Primary source
MGI:MGI:1913576
See related
Ensembl:ENSMUSG00000027606 AllianceGenome:MGI:1913576
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700008A05Rik
Summary
Predicted to be located in membrane. Is expressed in inner ear vestibular component. Orthologous to human DNAJC5B (DnaJ heat shock protein family (Hsp40) member C5 beta). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward testis adult (RPKM 67.1) See more
Orthologs
human all
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Genomic context

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See Dnajc5b in Genome Data Viewer
Location:
3 A2; 3 5.55 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (19562755..19665026)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (19508591..19610862)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr3:19250042-19250343 Neighboring gene predicted gene, 52602 Neighboring gene predicted gene, 42188 Neighboring gene STARR-seq mESC enhancer starr_07092 Neighboring gene STARR-seq mESC enhancer starr_07093 Neighboring gene STARR-positive B cell enhancer mm9_chr3:19330305-19330606 Neighboring gene STARR-seq mESC enhancer starr_07094 Neighboring gene STARR-seq mESC enhancer starr_07095 Neighboring gene STARR-seq mESC enhancer starr_07096 Neighboring gene predicted gene, 23330 Neighboring gene STARR-seq mESC enhancer starr_07097 Neighboring gene B-cell leukemia/lymphoma 10 pseudogene Neighboring gene nuclear encoded tRNA arginine 3 (anticodon ACG) Neighboring gene nuclear encoded tRNA tyrosine 1 (anticodon GTA)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cysteine string protein beta is prominently associated with nerve terminals and secretory organelles in mouse brain. Gundersen CB, et al. Brain Res, 2010 May 21. PMID 20338151
  2. Comparative gene expression study of the vestibular organ of the Igf1 deficient mouse using whole-transcript arrays. Rodríguez-de la Rosa L, et al. Hear Res, 2015 Dec. PMID 26341476
  3. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (2) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dnaJ homolog subfamily C member 5B
Names
CSP-beta
DnaJ (Hsp40) homolog, subfamily C, member 5 beta
beta cysteine string protein
beta-CSP
cysteine string protein beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163536.2 → NP_001157008.1  dnaJ homolog subfamily C member 5B

    See identical proteins and their annotated locations for NP_001157008.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AC141209, AC157815
    Consensus CDS
    CCDS17257.1
    UniProtKB/Swiss-Prot
    Q810R9, Q9CQ94
    Related
    ENSMUSP00000112849.2, ENSMUST00000118968.8
    Conserved Domains (1) summary
    COG0484
    Location:19 → 88
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

  2. NM_001163537.2 → NP_001157009.1  dnaJ homolog subfamily C member 5B

    See identical proteins and their annotated locations for NP_001157009.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
    Source sequence(s)
    AC141209, AC157815
    Consensus CDS
    CCDS17257.1
    UniProtKB/Swiss-Prot
    Q810R9, Q9CQ94
    Related
    ENSMUSP00000127515.2, ENSMUST00000165693.2
    Conserved Domains (1) summary
    COG0484
    Location:19 → 88
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

  3. NM_025489.4 → NP_079765.3  dnaJ homolog subfamily C member 5B

    See identical proteins and their annotated locations for NP_079765.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AC141209, AC157815
    Consensus CDS
    CCDS17257.1
    UniProtKB/Swiss-Prot
    Q810R9, Q9CQ94
    Related
    ENSMUSP00000029132.5, ENSMUST00000029132.11
    Conserved Domains (1) summary
    COG0484
    Location:19 → 88
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    19562755..19665026
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006535515.1 → XP_006535578.1  dnaJ homolog subfamily C member 5B isoform X1

    Conserved Domains (1) summary
    COG0484
    Location:19 → 88
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

  2. XM_006535516.1 → XP_006535579.1  dnaJ homolog subfamily C member 5B isoform X1

    See identical proteins and their annotated locations for XP_006535579.1

    UniProtKB/Swiss-Prot
    Q810R9, Q9CQ94
    Conserved Domains (1) summary
    COG0484
    Location:19 → 88
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CQ94.1 GenPept UniProtKB/Swiss-Prot:Q9CQ94

Gene LinkOut

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