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Tma16 translation machinery associated 16 [ Mus musculus (house mouse) ]

Gene ID: 66282, updated on 27-Nov-2024

Summary

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Official Symbol
Tma16provided by MGI
Official Full Name
translation machinery associated 16provided by MGI
Primary source
MGI:MGI:1913532
See related
Ensembl:ENSMUSG00000025591 AllianceGenome:MGI:1913532
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1810029B16Rik
Summary
Predicted to enable preribosome binding activity. Predicted to be involved in ribosomal large subunit biogenesis. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in nucleus. Is expressed in liver lobe and urethra. Orthologous to human TMA16 (translation machinery associated 16 homolog). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E11.5 (RPKM 3.1), CNS E14 (RPKM 2.3) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Tma16 in Genome Data Viewer
Location:
8 B3.1; 8 33.14 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (66928995..66939182, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (66476343..66486530, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene membrane associated ring-CH-type finger 1 Neighboring gene predicted gene, 26123 Neighboring gene STARR-seq mESC enhancer starr_21667 Neighboring gene predicted gene, 24205 Neighboring gene STARR-seq mESC enhancer starr_21668 Neighboring gene STARR-seq mESC enhancer starr_21669 Neighboring gene STARR-seq mESC enhancer starr_21670 Neighboring gene STARR-seq mESC enhancer starr_21671 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:69010363-69010546 Neighboring gene STARR-seq mESC enhancer starr_21673 Neighboring gene predicted gene, 32568 Neighboring gene transketolase-like 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  2. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables preribosome binding ISO
Inferred from Sequence Orthology
more info
  
enables preribosome binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in ribosomal large subunit biogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosomal large subunit biogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
translation machinery-associated protein 16
Names
UPF0534 protein C4orf43 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357208.1 → NP_001344137.1  translation machinery-associated protein 16 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC122800, AK031875, BC016246
    Conserved Domains (1) summary
    pfam11176
    Location:3 → 99
    Tma16; Translation machinery-associated protein 16

  2. NM_025465.3 → NP_079741.1  translation machinery-associated protein 16 isoform 1

    See identical proteins and their annotated locations for NP_079741.1

    Status: VALIDATED

    Source sequence(s)
    AC122800, AK031875, BC034844, BF020125
    Consensus CDS
    CCDS40353.1
    UniProtKB/Swiss-Prot
    Q05DD8, Q9CR02
    Related
    ENSMUSP00000026681.6, ENSMUST00000026681.7
    Conserved Domains (1) summary
    pfam11176
    Location:13 → 161
    DUF2962; Protein of unknown function (DUF2962)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    66928995..66939182 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CR02.1 GenPept UniProtKB/Swiss-Prot:Q9CR02

Gene LinkOut

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