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Pycr3 pyrroline-5-carboxylate reductase 3 [ Mus musculus (house mouse) ]

Gene ID: 66194, updated on 27-Nov-2024

Summary

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Official Symbol
Pycr3provided by MGI
Official Full Name
pyrroline-5-carboxylate reductase 3provided by MGI
Primary source
MGI:MGI:1913444
See related
Ensembl:ENSMUSG00000022571 AllianceGenome:MGI:1913444
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pycrl; 1110058B13Rik; 2700073G24Rik
Summary
Predicted to enable cytidine deaminase activity and pyrroline-5-carboxylate reductase activity. Predicted to be involved in L-proline biosynthetic process. Predicted to act upstream of or within cytidine deamination. Predicted to be located in cytosol; intercellular bridge; and mitotic spindle. Orthologous to human PYCR3 (pyrroline-5-carboxylate reductase 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in large intestine adult (RPKM 50.1), duodenum adult (RPKM 48.8) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Pycr3 in Genome Data Viewer
Location:
15 D3; 15 35.09 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (75788319..75793369, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (75916463..75921560, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene eukaryotic translation elongation factor 1 delta Neighboring gene tigger transposable element derived 5 Neighboring gene GDP-L-fucose synthase Neighboring gene zinc finger protein 623

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Protein-protein interaction panel using mouse full-length cDNAs. Suzuki H, et al. Genome Res, 2001 Oct. PMID 11591653, Free PMC Article
  2. The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase. Groh BS, et al. EMBO Rep, 2016 May. PMID 27113764, Free PMC Article
  3. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
  4. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767
  5. Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells. Zhang S, et al. Sci Data, 2018 Nov 20. PMID 30457570, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytidine deaminase activity ISO
Inferred from Sequence Orthology
more info
  
enables pyrroline-5-carboxylate reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pyrroline-5-carboxylate reductase activity ISO
Inferred from Sequence Orthology
more info
  
enables pyrroline-5-carboxylate reductase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in L-proline biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in L-proline biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in L-proline biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in L-proline biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within cytidine deamination ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in intercellular bridge IEA
Inferred from Electronic Annotation
more info
  
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
  
located_in mitotic spindle IEA
Inferred from Electronic Annotation
more info
  
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
pyrroline-5-carboxylate reductase 3
Names
P5C reductase 3
P5CR 3
pyrroline-5-carboxylate reductase-like protein
NP_079688.2
XP_006521315.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025412.3 → NP_079688.2  pyrroline-5-carboxylate reductase 3

    See identical proteins and their annotated locations for NP_079688.2

    Status: VALIDATED

    Source sequence(s)
    AC116520
    Consensus CDS
    CCDS37109.1
    UniProtKB/Swiss-Prot
    Q8R0P9, Q9D0X2, Q9DCC4
    Related
    ENSMUSP00000049605.8, ENSMUST00000053918.9
    Conserved Domains (3) summary
    PLN02688
    Location:10 → 273
    PLN02688; pyrroline-5-carboxylate reductase
    pfam03807
    Location:12 → 104
    F420_oxidored; NADP oxidoreductase coenzyme F420-dependent
    pfam14748
    Location:166 → 270
    P5CR_dimer; Pyrroline-5-carboxylate reductase dimerization

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    75788319..75793369 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521252.4 → XP_006521315.1  pyrroline-5-carboxylate reductase 3 isoform X1

    Conserved Domains (1) summary
    TIGR00112
    Location:1 → 161
    proC; pyrroline-5-carboxylate reductase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DCC4.2 GenPept UniProtKB/Swiss-Prot:Q9DCC4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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