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Tmem176a transmembrane protein 176A [ Mus musculus (house mouse) ]

Gene ID: 66058, updated on 27-Nov-2024

Summary

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Official Symbol
Tmem176aprovided by MGI
Official Full Name
transmembrane protein 176Aprovided by MGI
Primary source
MGI:MGI:1913308
See related
Ensembl:ENSMUSG00000023367 AllianceGenome:MGI:1913308
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Keg2; 0610011I04Rik
Summary
Acts upstream of or within negative regulation of dendritic cell differentiation. Predicted to be located in membrane. Is expressed in several structures, including ganglia; metanephros; notochord; sensory organ; and thymus primordium. Orthologous to human TMEM176A (transmembrane protein 176A). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in kidney adult (RPKM 212.4), adrenal adult (RPKM 143.6) and 19 other tissues See more
Orthologs
human all
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Genomic context

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See Tmem176a in Genome Data Viewer
Location:
6 B2.3; 6 23.75 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (48818417..48822298)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (48841483..48845364)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene septin 7 pseudogene Neighboring gene transmembrane protein 176B Neighboring gene predicted gene 44764 Neighboring gene predicted gene 7932 Neighboring gene STARR-seq mESC enhancer starr_15799 Neighboring gene amine oxidase, copper-containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Generation of a Double KO Mouse by Simultaneous Targeting of the Neighboring Genes Tmem176a and Tmem176b Using CRISPR/Cas9: Key Steps from Design to Genotyping. Lemoine A, et al. J Genet Genomics, 2016 May 20. PMID 27234594
  2. Dendritic Cells Require TMEM176A/B Ion Channels for Optimal MHC Class II Antigen Presentation to Naive CD4(+) T Cells. Lancien M, et al. J Immunol, 2021 Jul 15. PMID 34233909
  3. Tmem176B and Tmem176A are associated with the immature state of dendritic cells. Condamine T, et al. J Leukoc Biol, 2010 Sep. PMID 20501748
  4. RORγt+ cells selectively express redundant cation channels linked to the Golgi apparatus. Drujont L, et al. Sci Rep, 2016 Mar 24. PMID 27009467, Free PMC Article
  5. A collection of cDNAs enriched in upper cortical layers of the embryonic mouse brain. García-Frigola C, et al. Brain Res Mol Brain Res, 2004 Mar 30. PMID 15010206

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dendritic Cells Require TMEM176A/B Ion Channels for Optimal MHC Class II Antigen Presentation to Naive CD4(+) T Cells.
    Title: Dendritic Cells Require TMEM176A/B Ion Channels for Optimal MHC Class II Antigen Presentation to Naive CD4(+) T Cells.
  2. Study characterized Tmem176a and b expression in RORgamma t+ lymphocytes at transcriptional and protein levels and present evidence that both genes exert a redundant ion channel function related to a colocalisation in close proximity to the Golgi apparatus.
    Title: RORγt+ cells selectively express redundant cation channels linked to the Golgi apparatus.
  3. These data suggest that Tmem176B and Tmem176A associate to form multimers and restrain dendritic cell maturation.
    Title: Tmem176B and Tmem176A are associated with the immature state of dendritic cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of dendritic cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transmembrane protein 176A
Names
gene signature 188
kidney expressed gene 2
kidney-expressed gene 2 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098271.1 → NP_001091741.1  transmembrane protein 176A

    See identical proteins and their annotated locations for NP_001091741.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK002546, BY352519
    Consensus CDS
    CCDS39482.1
    UniProtKB/Swiss-Prot
    Q3UCE2, Q8BV92, Q8K4T0, Q9DCS1
    UniProtKB/TrEMBL
    A0A0N4SVU8
    Related
    ENSMUSP00000131775.2, ENSMUST00000168406.4
    Conserved Domains (1) summary
    pfam04103
    Location:63 → 223
    CD20; CD20-like family

  2. NM_025326.4 → NP_079602.4  transmembrane protein 176A

    See identical proteins and their annotated locations for NP_079602.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK002546, BY018646
    Consensus CDS
    CCDS39482.1
    UniProtKB/Swiss-Prot
    Q3UCE2, Q8BV92, Q8K4T0, Q9DCS1
    UniProtKB/TrEMBL
    A0A0N4SVU8
    Related
    ENSMUSP00000098969.5, ENSMUST00000101426.11
    Conserved Domains (1) summary
    pfam04103
    Location:63 → 223
    CD20; CD20-like family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    48818417..48822298
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DCS1.2 GenPept UniProtKB/Swiss-Prot:Q9DCS1

Gene LinkOut

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