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Zdhhc16 zinc finger DHHC-type palmitoyltransferase 16 [ Rattus norvegicus (Norway rat) ]

Gene ID: 654495, updated on 27-Nov-2024

Summary

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Official Symbol
Zdhhc16provided by RGD
Official Full Name
zinc finger DHHC-type palmitoyltransferase 16provided by RGD
Primary source
RGD:1591893
See related
EnsemblRapid:ENSRNOG00000046530 AllianceGenome:RGD:1591893
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable palmitoyltransferase activity. Predicted to be involved in several processes, including eye development; fibroblast growth factor receptor signaling pathway involved in forebrain neuron fate commitment; and protein palmitoylation. Predicted to be located in membrane. Predicted to be active in Golgi apparatus. Orthologous to human ZDHHC16 (zinc finger DHHC-type palmitoyltransferase 16). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 105.9), Kidney (RPKM 103.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Zdhhc16 in Genome Data Viewer
Location:
1q54
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (250694922..250706319)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (240745606..240757009)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (261179971..261191374)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene phosphoglycerate mutase 1 Neighboring gene exosome component 1 Neighboring gene MMS19 homolog, cytosolic iron-sulfur assembly component Neighboring gene U6 spliceosomal RNA Neighboring gene ubiquitin domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A potential role for protein palmitoylation and zDHHC16 in DNA damage response. Cao N, et al. BMC Mol Biol, 2016 May 10. PMID 27159997, Free PMC Article
  2. Identification and dynamics of the human ZDHHC16-ZDHHC6 palmitoylation cascade. Abrami L, et al. Elife, 2017 Aug 15. PMID 28826475, Free PMC Article
  3. Palmitoyl acyltransferase Aph2 in cardiac function and the development of cardiomyopathy. Zhou T, et al. Proc Natl Acad Sci U S A, 2015 Dec 22. PMID 26644582, Free PMC Article
  4. Analysis of substrate specificity of human DHHC protein acyltransferases using a yeast expression system. Ohno Y, et al. Mol Biol Cell, 2012 Dec. PMID 23034182, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC156465

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables palmitoyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-cysteine S-palmitoyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA damage response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in eye development ISO
Inferred from Sequence Orthology
more info
  
involved_in fibroblast growth factor receptor signaling pathway involved in forebrain neuron fate commitment IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in heart development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in heart development ISO
Inferred from Sequence Orthology
more info
  
involved_in protein palmitoylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
palmitoyltransferase ZDHHC16
Names
membrane-associated DHHC16 zinc finger protein
probable palmitoyltransferase ZDHHC16
zinc finger, DHHC domain containing 16
zinc finger, DHHC-type containing 16
NP_001034435.2
NP_001388198.1
NP_001388199.1
XP_006231467.1
XP_006231469.1
XP_038946073.1
XP_038946084.1
XP_038946104.1
XP_038946106.1
XP_063129188.1
XP_063129208.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039346.2 → NP_001034435.2  palmitoyltransferase ZDHHC16 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0JPI5
    Related
    ENSRNOP00000080251.2, ENSRNOT00000115815.2

  2. NM_001401269.1 → NP_001388198.1  palmitoyltransferase ZDHHC16 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I6G4A8
    Related
    ENSRNOP00000097298.2, ENSRNOT00000109287.2

  3. NM_001401270.1 → NP_001388199.1  palmitoyltransferase ZDHHC16 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    Related
    ENSRNOP00000109011.1, ENSRNOT00000145842.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    250694922..250706319
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063273138.1 → XP_063129208.1  palmitoyltransferase ZDHHC16 isoform X6

  2. XM_039090156.2 → XP_038946084.1  palmitoyltransferase ZDHHC16 isoform X3

    UniProtKB/TrEMBL
    A0A8I6AU65
    Conserved Domains (1) summary
    pfam01529
    Location:156 → 305
    DHHC; DHHC palmitoyltransferase

  3. XM_006231405.5 → XP_006231467.1  palmitoyltransferase ZDHHC16 isoform X4

    UniProtKB/TrEMBL
    Q2TGJ3
    Conserved Domains (1) summary
    pfam01529
    Location:91 → 240
    DHHC; DHHC palmitoyltransferase

  4. XM_006231407.5 → XP_006231469.1  palmitoyltransferase ZDHHC16 isoform X5

    UniProtKB/TrEMBL
    Q2TGJ3
    Conserved Domains (1) summary
    pfam01529
    Location:91 → 224
    DHHC; DHHC palmitoyltransferase

  5. XM_039090145.2 → XP_038946073.1  palmitoyltransferase ZDHHC16 isoform X1

    UniProtKB/TrEMBL
    A0A8I6G4A8, Q2TGJ3
    Related
    ENSRNOP00000066326.2, ENSRNOT00000072181.3
    Conserved Domains (1) summary
    pfam01529
    Location:156 → 305
    DHHC; DHHC palmitoyltransferase

  6. XM_063273118.1 → XP_063129188.1  palmitoyltransferase ZDHHC16 isoform X2

    UniProtKB/TrEMBL
    A0JPI5

  7. XM_039090176.2 → XP_038946104.1  palmitoyltransferase ZDHHC16 isoform X7

    UniProtKB/TrEMBL
    A6JH97
    Conserved Domains (1) summary
    pfam01529
    Location:1 → 125
    DHHC; DHHC palmitoyltransferase

  8. XM_039090178.2 → XP_038946106.1  palmitoyltransferase ZDHHC16 isoform X7

    UniProtKB/TrEMBL
    A6JH97
    Conserved Domains (1) summary
    pfam01529
    Location:1 → 125
    DHHC; DHHC palmitoyltransferase

RNA

  1. XR_005492011.2 RNA Sequence

  2. XR_010057365.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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