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Lpar3 lysophosphatidic acid receptor 3 [ Mus musculus (house mouse) ]

Gene ID: 65086, updated on 27-Nov-2024

Summary

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Official Symbol
Lpar3provided by MGI
Official Full Name
lysophosphatidic acid receptor 3provided by MGI
Primary source
MGI:MGI:1929469
See related
Ensembl:ENSMUSG00000036832 AllianceGenome:MGI:1929469
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Edg7; lpA3
Summary
Predicted to enable G protein-coupled receptor activity; G-protein alpha-subunit binding activity; and phospholipid binding activity. Involved in gene expression. Acts upstream of or within several processes, including bleb assembly; positive regulation of MAPK cascade; and positive regulation of collateral sprouting. Located in axon. Is expressed in several structures, including alimentary system; central nervous system; hemolymphoid system gland; rib; and sensory organ. Orthologous to human LPAR3 (lysophosphatidic acid receptor 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in kidney adult (RPKM 14.3), testis adult (RPKM 9.9) and 11 other tissues See more
Orthologs
human all
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Genomic context

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See Lpar3 in Genome Data Viewer
Location:
3 H2; 3 71.03 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (145926716..145991969)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (146220961..146286214)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene mucolipin 3 Neighboring gene STARR-positive B cell enhancer mm9_chr3:145797888-145798188 Neighboring gene predicted gene, 25627 Neighboring gene STARR-positive B cell enhancer mm9_chr3:145815297-145815597 Neighboring gene mucolipin 2 Neighboring gene STARR-positive B cell enhancer ABC_E9580 Neighboring gene STARR-positive B cell enhancer mm9_chr3:145847906-145848206 Neighboring gene STARR-seq mESC enhancer starr_09219 Neighboring gene STARR-positive B cell enhancer mm9_chr3:145920440-145920741 Neighboring gene STARR-seq mESC enhancer starr_09220 Neighboring gene STARR-seq mESC enhancer starr_09221 Neighboring gene predicted gene, 40167 Neighboring gene predicted gene 10636

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. LPA3-mediated lysophosphatidic acid signalling in embryo implantation and spacing. Ye X, et al. Nature, 2005 May 5. PMID 15875025, Free PMC Article
  2. Paradoxical downregulation of LPAR3 exerts tumor-promoting activity through autophagy induction in Ras-transformed cells. Hwang SH, et al. BMC Cancer, 2022 Sep 10. PMID 36088312, Free PMC Article
  3. Deletion of Lysophosphatidic Acid Receptor 3 (Lpar3) Disrupts Fine Local Balance of Progesterone and Estrogen Signaling in Mouse Uterus During Implantation. Diao H, et al. Biol Reprod, 2015 Nov. PMID 26447143, Free PMC Article
  4. Lysophosphatidic receptor, LPA3, is positively and negatively regulated by progesterone and estrogen in the mouse uterus. Hama K, et al. Life Sci, 2006 Sep 27. PMID 16815476
  5. Embryo spacing and implantation timing are differentially regulated by LPA3-mediated lysophosphatidic acid signaling in mice. Hama K, et al. Biol Reprod, 2007 Dec. PMID 17823089

See all (67) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Paradoxical downregulation of LPAR3 exerts tumor-promoting activity through autophagy induction in Ras-transformed cells.
    Title: Paradoxical downregulation of LPAR3 exerts tumor-promoting activity through autophagy induction in Ras-transformed cells.
  2. LPA3-mediated lysophosphatidic acid signaling promotes postnatal heart regeneration in mice.
    Title: LPA(3)-mediated lysophosphatidic acid signaling promotes postnatal heart regeneration in mice.
  3. Lysophosphatidic acid receptors 2 and 3 regulate erythropoiesis at different hematopoietic stages.
    Title: Lysophosphatidic acid receptors 2 and 3 regulate erythropoiesis at different hematopoietic stages.
  4. Mechanical and signaling mechanisms that guide pre-implantation embryo movement.
    Title: Mechanical and signaling mechanisms that guide pre-implantation embryo movement.
  5. inhibition of LPA1/3 receptor abolished lysophosphatidic acid-induced elevation of the osteogenic and angiogenic capability of pre-osteoblasts.
    Title: Lysophosphatidic acid enhanced the osteogenic and angiogenic capability of osteoblasts via LPA1/3 receptor.
  6. Osteoglycin negatively regulates cardiac fibrotic remodelling by attenuating myofibroblast proliferation and migration through LPA3-mediated and Rho/ROCK-dependent inhibition of MT1-MMP translocation, MMP2 activation and EGFR transactivation.
    Title: Osteoglycin attenuates cardiac fibrosis by suppressing cardiac myofibroblast proliferation and migration through antagonizing lysophosphatidic acid 3/matrix metalloproteinase 2/epidermal growth factor receptor signalling.
  7. we demonstrate that LPA1/3 antagonism mildly reduced plasma LDL cholesterol levels. Therefore, pharmacological inhibition of LPA1/3 receptors may prove a promising approach to diminish atherosclerosis development.
    Title: Inhibition of lysophosphatidic acid receptors 1 and 3 attenuates atherosclerosis development in LDL-receptor deficient mice.
  8. These results indicate that ATX-lysophosphatidic acid-LPA3 signaling at the embryo-epithelial boundary induces decidualization via the canonical HB-EGF and COX-2 pathways.
    Title: Autotaxin-lysophosphatidic acid-LPA(3) signaling at the embryo-epithelial boundary controls decidualization pathways.
  9. Lpar3(-/-) female mice had delayed embryo implantation.
    Title: Deletion of Lysophosphatidic Acid Receptor 3 (Lpar3) Disrupts Fine Local Balance of Progesterone and Estrogen Signaling in Mouse Uterus During Implantation.
  10. These results suggest that LPA3 receptor-mediated amplification of spinal LPA production is required for the development of paclitaxel-induced neuropathic pain.
    Title: Lysophosphatidic acid and its receptors LPA1 and LPA3 mediate paclitaxel-induced neuropathic pain in mice.
Submit: New GeneRIF Correction See all GeneRIFs (19)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G-protein alpha-subunit binding ISO
Inferred from Sequence Orthology
more info
  
enables lysophosphatidic acid receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables phospholipid binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within bleb assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of collateral sprouting IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of calcium ion transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of collateral sprouting IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
lysophosphatidic acid receptor 3
Names
LPA receptor 3
LPA-3
endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor 7
lysophosphatidic acid receptor Edg-7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022983.4 → NP_075359.1  lysophosphatidic acid receptor 3

    See identical proteins and their annotated locations for NP_075359.1

    Status: VALIDATED

    Source sequence(s)
    AC122513, AK042084
    Consensus CDS
    CCDS17901.1
    UniProtKB/Swiss-Prot
    Q9EQ31
    UniProtKB/TrEMBL
    Q544B4
    Related
    ENSMUSP00000037712.3, ENSMUST00000039164.4
    Conserved Domains (2) summary
    pfam00001
    Location:48 → 293
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:42 → 309
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    145926716..145991969
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9EQ31.1 GenPept UniProtKB/Swiss-Prot:Q9EQ31

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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