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Vps33a VPS33A core subunit of CORVET and HOPS complexes [ Rattus norvegicus (Norway rat) ]

Gene ID: 65081, updated on 27-Nov-2024

Summary

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Official Symbol
Vps33aprovided by RGD
Official Full Name
VPS33A core subunit of CORVET and HOPS complexesprovided by RGD
Primary source
RGD:620643
See related
EnsemblRapid:ENSRNOG00000056889 AllianceGenome:RGD:620643
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
r-Vps33a
Summary
Predicted to be involved in several processes, including autophagosome maturation; melanosome localization; and regulation of lysosomal lumen pH. Predicted to act upstream of or within pigmentation; platelet formation; and regulation of developmental pigmentation. Predicted to be located in autophagosome; endosome; and perinuclear region of cytoplasm. Predicted to be part of several cellular components, including AP-3 adaptor complex; CORVET complex; and clathrin complex. Predicted to be active in lysosome. Orthologous to human VPS33A (VPS33A core subunit of CORVET and HOPS complexes). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 79.2), Brain (RPKM 78.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Vps33a in Genome Data Viewer
Location:
12q16
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (38685484..38710668)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (33024596..33051399)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (38459816..38482903)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene CAP-GLY domain containing linker protein 1 Neighboring gene uncharacterized LOC134481295 Neighboring gene uncharacterized LOC120095846 Neighboring gene diablo, IAP-binding mitochondrial protein Neighboring gene UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 Neighboring gene leucine rich repeat containing 43

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The mouse organellar biogenesis mutant buff results from a mutation in Vps33a, a homologue of yeast vps33 and Drosophila carnation. Suzuki T, et al. Proc Natl Acad Sci U S A, 2003 Feb 4. PMID 12538872, Free PMC Article
  2. Mutation in VPS33A affects metabolism of glycosaminoglycans: a new type of mucopolysaccharidosis with severe systemic symptoms. Kondo H, et al. Hum Mol Genet, 2017 Jan 1. PMID 28013294
  3. Genetic control of glucuronidase induction in mice. Swank RT, et al. J Mol Biol, 1973 Dec 5. PMID 4777306
  4. Comparative evolutionary analysis of VPS33 homologues: genetic and functional insights. Gissen P, et al. Hum Mol Genet, 2005 May 15. PMID 15790593
  5. Molecular characterization of mammalian homologues of class C Vps proteins that interact with syntaxin-7. Kim BY, et al. J Biol Chem, 2001 Aug 3. PMID 11382755

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in autophagosome maturation IEA
Inferred from Electronic Annotation
more info
  
involved_in autophagosome maturation ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in endosome to lysosome transport IEA
Inferred from Electronic Annotation
more info
  
involved_in endosome to lysosome transport ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lysosome localization IEA
Inferred from Electronic Annotation
more info
  
involved_in lysosome localization ISO
Inferred from Sequence Orthology
more info
  
involved_in melanosome localization IEA
Inferred from Electronic Annotation
more info
  
involved_in melanosome localization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within pigmentation ISO
Inferred from Sequence Orthology
more info
  
involved_in platelet formation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within platelet formation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of developmental pigmentation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of developmental pigmentation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of lysosomal lumen pH IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of lysosomal lumen pH ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of lysosomal lumen pH ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of AP-3 adaptor complex IEA
Inferred from Electronic Annotation
more info
  
part_of AP-3 adaptor complex ISO
Inferred from Sequence Orthology
more info
  
part_of CORVET complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of CORVET complex IEA
Inferred from Electronic Annotation
more info
  
part_of CORVET complex ISO
Inferred from Sequence Orthology
more info
  
part_of HOPS complex IEA
Inferred from Electronic Annotation
more info
  
part_of HOPS complex ISO
Inferred from Sequence Orthology
more info
  
located_in autophagosome IEA
Inferred from Electronic Annotation
more info
  
located_in autophagosome ISO
Inferred from Sequence Orthology
more info
  
located_in autophagosome ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of clathrin complex IEA
Inferred from Electronic Annotation
more info
  
part_of clathrin complex ISO
Inferred from Sequence Orthology
more info
  
located_in clathrin-coated vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in early endosome IEA
Inferred from Electronic Annotation
more info
  
located_in early endosome ISO
Inferred from Sequence Orthology
more info
  
located_in late endosome ISO
Inferred from Sequence Orthology
more info
  
located_in late endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosome ISO
Inferred from Sequence Orthology
more info
  
located_in lysosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
vacuolar protein sorting-associated protein 33A
Names
VPS33A CORVET/HOPS core subunit
vacuolar protein sorting 33 homolog A
vacuolar protein sorting 33A
vacuolar protein sorting protein 33a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022961.3 → NP_075250.2  vacuolar protein sorting-associated protein 33A

    See identical proteins and their annotated locations for NP_075250.2

    Status: PROVISIONAL

    Source sequence(s)
    BC105752
    UniProtKB/Swiss-Prot
    Q63615
    UniProtKB/TrEMBL
    A0A0G2K5N1, A0A9K3Y802, Q3KRF0
    Related
    ENSRNOP00000073489.2, ENSRNOT00000090343.3
    Conserved Domains (1) summary
    pfam00995
    Location:34 → 585
    Sec1; Sec1 family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    38685484..38710668
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039089725.2 → XP_038945653.1  vacuolar protein sorting-associated protein 33A isoform X1

    Conserved Domains (1) summary
    pfam00995
    Location:34 → 435
    Sec1; Sec1 family

  2. XM_039089726.2 → XP_038945654.1  vacuolar protein sorting-associated protein 33A isoform X2

    Conserved Domains (1) summary
    pfam00995
    Location:34 → 317
    Sec1; Sec1 family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q63615.1 GenPept UniProtKB/Swiss-Prot:Q63615

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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