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vox ventral homeobox [ Danio rerio (zebrafish) ]

Gene ID: 64807, updated on 9-Dec-2024

Summary

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Official Symbol
voxprovided by ZNC
Official Full Name
ventral homeoboxprovided by ZNC
Primary source
ZFIN:ZDB-GENE-010108-1
See related
Ensembl:ENSDARG00000099761 AllianceGenome:ZFIN:ZDB-GENE-010108-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
vega1; zgc:136532
Summary
Enables protein heterodimerization activity and protein homodimerization activity. Acts upstream of or within dorsal/ventral pattern formation; regulation of endodermal cell fate specification; and regulation of mesodermal cell fate specification. Predicted to be located in nucleus. Is expressed in several structures, including cloacal chamber; embryonic structure; epidermis; hindbrain neural plate; and midbrain neural keel. Orthologous to human VENTX (VENT homeobox). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See vox in Genome Data Viewer
Location:
chromosome: 13
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (50621929..50624154, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (50307020..50309245, complement)

Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene microRNA 202 Neighboring gene ventral expressed homeobox Neighboring gene uncharacterized LOC103912045 Neighboring gene kinase non-catalytic C-lobe domain containing 1 Neighboring gene uncharacterized LOC137487448

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. vox homeobox gene: a novel regulator of midbrain-hindbrain boundary development in medaka fish? Fabian P, et al. Dev Genes Evol, 2016 Mar. PMID 26965282
  2. The proteins of Vent-family and their mRNAs are located in different areas of the tails of Zebrafish and Xenopus embryos. Pshennikova ES, et al. Int J Biochem Cell Biol, 2016 Oct. PMID 27620076
  3. Conservation and diversification of an ancestral chordate gene regulatory network for dorsoventral patterning. Kozmikova I, et al. PLoS One, 2011 Feb 3. PMID 21304903, Free PMC Article
  4. The Vox mRNA and protein expression in zebrafish Pou5f3 MZspg mutant embryos. Voronina A, et al. Stem Cell Investig, 2016. PMID 28066781, Free PMC Article
  5. Expression of vox and vent mRNAs and encoded proteins in zebrafish embryos. Pshennikova ES, et al. Stem Cell Investig, 2017. PMID 28725656, Free PMC Article

See all (83) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Vent-family and their mRNAs are located in different areas of the tails of Zebrafish and Xenopus embryos
    Title: The proteins of Vent-family and their mRNAs are located in different areas of the tails of Zebrafish and Xenopus embryos.
  2. Vox plays a key role downstream of BMP signals in regulating the capacity of Nodal to induce endoderm versus mesoderm by modulating the activity of the Casanova/Pou2 regulatory system.
    Title: The transcription factor Vox represses endoderm development by interacting with Casanova and Pou2.
  3. show that Pou5f1 binds to phylogenetically conserved Oct/Pou5f1 sites in the vox promoter, both in vivo and in vitro
    Title: Pou5f1 contributes to dorsoventral patterning by positive regulation of vox and modulation of fgf8a expression.
  4. ved functions redundantly with vox/vega1 and vent/vega2 to restrict the organizer domain in zebrafish
    Title: A novel repressor-type homeobox gene, ved, is involved in dharma/bozozok-mediated dorsal organizer formation in zebrafish.
  5. vox plays a critical role in the establishment of the dorsoventral axis.
    Title: Functional and hierarchical interactions among zebrafish vox/vent homeobox genes.
  6. Regulation by Wnt8 restricts the size of the dorsal organizer in embryo.
    Title: Repression of the vertebrate organizer by Wnt8 is mediated by Vent and Vox.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC136532

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within dorsal/ventral pattern formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of endodermal cell fate specification IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of endodermal cell fate specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of mesodermal cell fate specification IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within spinal cord motor neuron cell fate specification IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ventral homeobox

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131698.1 → NP_571773.1  ventral homeobox

    See identical proteins and their annotated locations for NP_571773.1

    Status: PROVISIONAL

    Source sequence(s)
    AF193837
    UniProtKB/TrEMBL
    Q9DG33
    Related
    ENSDARP00000131684.1, ENSDART00000167949.3
    Conserved Domains (2) summary
    COG5576
    Location:75 → 187
    COG5576; Homeodomain-containing transcription factor [Transcription]
    pfam00046
    Location:121 → 173
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007124.7 Reference GRCz11 Primary Assembly

    Range
    50621929..50624154 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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