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EFCAB6 EF-hand calcium binding domain 6 [ Homo sapiens (human) ]

Gene ID: 64800, updated on 27-Nov-2024

Summary

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Official Symbol
EFCAB6provided by HGNC
Official Full Name
EF-hand calcium binding domain 6provided by HGNC
Primary source
HGNC:HGNC:24204
See related
Ensembl:ENSG00000186976 MIM:619664; AllianceGenome:HGNC:24204
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DJBP; HSCBCIP1; dJ185D5.1
Summary
This gene encodes a protein which directly binds the oncogene DJ-1 and androgen receptor to form a ternary complex in cells. This binding protein recruits histone-deacetylase complexes in order to repress transcription activity of androgen receptor. This protein may also play a role in spermatogenesis and fertilization. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Expression
Biased expression in testis (RPKM 13.3) and thyroid (RPKM 1.2) See more
Orthologs
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Genomic context

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See EFCAB6 in Genome Data Viewer
Location:
22q13.2-q13.31
Exon count:
42
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (43528778..43812305, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (44011227..44295198, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (43924658..44208185, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1639 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:43823805-43824306 Neighboring gene MPRA-validated peak4505 silencer Neighboring gene metallophosphoesterase domain containing 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:43860857-43861358 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:43883063-43883836 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:43883837-43884610 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:43910482-43911240 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:43923573-43924072 Neighboring gene EFCAB6 antisense RNA 1 Neighboring gene NANOG hESC enhancer GRCh37_chr22:43932755-43933256 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:43938541-43939320 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:43939321-43940098 Neighboring gene uncharacterized LOC101927474 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:43966769-43967269 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:44030735-44031236 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:44039364-44039864 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr22:44047371-44047871 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:44054653-44055349 Neighboring gene YWHAQ pseudogene 2 Neighboring gene uncharacterized LOC124905130 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:44101993-44102658 Neighboring gene ribosomal protein L4 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19191 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:44208791-44209592 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:44207707-44207948 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:44215896-44216537 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:44223866-44224628 Neighboring gene EFCAB6 divergent transcript Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 9 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:44240991-44241816 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:44247635-44248134 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:44256209-44256708 Neighboring gene sulfotransferase family 4A member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. DJBP: a novel DJ-1-binding protein, negatively regulates the androgen receptor by recruiting histone deacetylase complex, and DJ-1 antagonizes this inhibition by abrogation of this complex. Niki T, et al. Mol Cancer Res, 2003 Feb. PMID 12612053
  2. Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping. Hirosawa M, et al. DNA Res, 2001 Feb 28. PMID 11258795
  3. Reevaluating human gene annotation: a second-generation analysis of chromosome 22. Collins JE, et al. Genome Res, 2003 Jan. PMID 12529303, Free PMC Article
  4. Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. Lauc G, et al. PLoS Genet, 2013. PMID 23382691, Free PMC Article
  5. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. Trynka G, et al. Gut, 2009 Aug. PMID 19240061

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Observational study of gene-disease association. (HuGE Navigator)
    Title: Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.
  2. androgen receptor is positively regulated by DJ-1, which antagonizes the function of negative regulators, including DJBP, a novel DJ-1-binding protein
    Title: DJBP: a novel DJ-1-binding protein, negatively regulates the androgen receptor by recruiting histone deacetylase complex, and DJ-1 antagonizes this inhibition by abrogation of this complex.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ23588, KIAA1672

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in flagellated sperm motility ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in axonemal A tubule inner sheath IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in sperm flagellum ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
EF-hand calcium-binding domain-containing protein 6
Names
CAP-binding protein complex-interacting protein 1
DJ-1-binding protein
epididymis secretory sperm binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030019.1 RefSeqGene

    Range
    5033..288560
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_022785.4 → NP_073622.2  EF-hand calcium-binding domain-containing protein 6 isoform a

    See identical proteins and their annotated locations for NP_073622.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK058069, AK292411, BC039315, BP325901
    Consensus CDS
    CCDS14049.1
    UniProtKB/Swiss-Prot
    A8K8P6, A8K8Y3, B0QYI4, B0QYI6, Q5THR3, Q5U5T6, Q9BY88, Q9H5C4, Q9NSF5
    UniProtKB/TrEMBL
    A0A384ME20
    Related
    ENSP00000262726.7, ENST00000262726.12
    Conserved Domains (4) summary
    COG5126
    Location:294 → 469
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    pfam08976
    Location:1160 → 1260
    EF-hand_11; EF-hand domain
    pfam13499
    Location:1439 → 1499
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:408 → 468
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  2. NM_198856.3 → NP_942153.1  EF-hand calcium-binding domain-containing protein 6 isoform b

    See identical proteins and their annotated locations for NP_942153.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding region compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AK058069, AK292411, BC039315, BP325901
    Consensus CDS
    CCDS14050.1
    UniProtKB/TrEMBL
    A0A384ME20
    Related
    ENSP00000379533.2, ENST00000396231.6
    Conserved Domains (4) summary
    COG5126
    Location:142 → 317
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    pfam08976
    Location:1008 → 1108
    EF-hand_11; EF-hand domain
    pfam13499
    Location:1287 → 1347
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:256 → 316
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    43528778..43812305 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047441462.1 → XP_047297418.1  EF-hand calcium-binding domain-containing protein 6 isoform X9

  2. XM_011530319.4 → XP_011528621.1  EF-hand calcium-binding domain-containing protein 6 isoform X5

    See identical proteins and their annotated locations for XP_011528621.1

    UniProtKB/TrEMBL
    A0A384ME20
    Conserved Domains (4) summary
    COG5126
    Location:188 → 363
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    pfam08976
    Location:1054 → 1154
    EF-hand_11; EF-hand domain
    pfam13499
    Location:71 → 129
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:302 → 362
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  3. XM_011530317.4 → XP_011528619.1  EF-hand calcium-binding domain-containing protein 6 isoform X2

    See identical proteins and their annotated locations for XP_011528619.1

    UniProtKB/TrEMBL
    A0A384ME20
    Conserved Domains (5) summary
    COG5126
    Location:294 → 469
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd00051
    Location:408 → 468
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam08976
    Location:1160 → 1260
    EF-hand_11; EF-hand domain
    pfam13499
    Location:177 → 235
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:177 → 235
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  4. XM_011530321.4 → XP_011528623.1  EF-hand calcium-binding domain-containing protein 6 isoform X7

    See identical proteins and their annotated locations for XP_011528623.1

    UniProtKB/TrEMBL
    A0A384ME20
    Conserved Domains (4) summary
    pfam08976
    Location:1008 → 1108
    EF-hand_11; EF-hand domain
    pfam13499
    Location:704 → 758
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:256 → 316
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cl25352
    Location:142 → 317
    EFh_PEF; The penta-EF hand (PEF) family

  5. XM_047441461.1 → XP_047297417.1  EF-hand calcium-binding domain-containing protein 6 isoform X7

  6. XM_005261704.3 → XP_005261761.1  EF-hand calcium-binding domain-containing protein 6 isoform X2

    See identical proteins and their annotated locations for XP_005261761.1

    UniProtKB/TrEMBL
    A0A384ME20
    Conserved Domains (5) summary
    COG5126
    Location:294 → 469
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd00051
    Location:408 → 468
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam08976
    Location:1160 → 1260
    EF-hand_11; EF-hand domain
    pfam13499
    Location:177 → 235
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:177 → 235
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  7. XM_011530318.4 → XP_011528620.1  EF-hand calcium-binding domain-containing protein 6 isoform X3

    UniProtKB/TrEMBL
    A0A384ME20
    Conserved Domains (5) summary
    COG5126
    Location:268 → 443
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd00051
    Location:382 → 442
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam08976
    Location:1134 → 1234
    EF-hand_11; EF-hand domain
    pfam13499
    Location:101 → 171
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:151 → 209
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  8. XM_017028911.3 → XP_016884400.1  EF-hand calcium-binding domain-containing protein 6 isoform X4

    UniProtKB/TrEMBL
    A0A384ME20

  9. XM_017028910.3 → XP_016884399.1  EF-hand calcium-binding domain-containing protein 6 isoform X1

    UniProtKB/TrEMBL
    A0A384ME20
    Conserved Domains (5) summary
    COG5126
    Location:320 → 495
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd00051
    Location:434 → 494
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam08976
    Location:1186 → 1286
    EF-hand_11; EF-hand domain
    pfam13499
    Location:203 → 261
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:100 → 152
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  10. XM_011530316.2 → XP_011528618.1  EF-hand calcium-binding domain-containing protein 6 isoform X1

    UniProtKB/TrEMBL
    A0A384ME20
    Conserved Domains (5) summary
    COG5126
    Location:320 → 495
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd00051
    Location:434 → 494
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam08976
    Location:1186 → 1286
    EF-hand_11; EF-hand domain
    pfam13499
    Location:203 → 261
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:100 → 152
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  11. XM_011530325.3 → XP_011528627.1  EF-hand calcium-binding domain-containing protein 6 isoform X10

    UniProtKB/TrEMBL
    A0A384ME20
    Conserved Domains (4) summary
    COG5126
    Location:46 → 221
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd00051
    Location:160 → 220
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam08976
    Location:912 → 1012
    EF-hand_11; EF-hand domain
    cl08302
    Location:937 → 990
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  12. XM_011530323.3 → XP_011528625.1  EF-hand calcium-binding domain-containing protein 6 isoform X8

    UniProtKB/TrEMBL
    A0A384ME20
    Conserved Domains (4) summary
    COG5126
    Location:140 → 315
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    pfam08976
    Location:1006 → 1106
    EF-hand_11; EF-hand domain
    pfam13499
    Location:23 → 81
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:254 → 314
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  13. XM_011530327.3 → XP_011528629.1  EF-hand calcium-binding domain-containing protein 6 isoform X12

    UniProtKB/TrEMBL
    A0A384ME20
    Conserved Domains (4) summary
    COG5126
    Location:655 → 801
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd00051
    Location:100 → 160
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam08976
    Location:852 → 952
    EF-hand_11; EF-hand domain
    cl08302
    Location:877 → 930
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  14. XM_047441464.1 → XP_047297420.1  EF-hand calcium-binding domain-containing protein 6 isoform X15

  15. XM_011530320.4 → XP_011528622.1  EF-hand calcium-binding domain-containing protein 6 isoform X6

    UniProtKB/TrEMBL
    A0A384ME20
    Conserved Domains (4) summary
    COG5126
    Location:320 → 495
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    pfam08976
    Location:1186 → 1286
    EF-hand_11; EF-hand domain
    pfam13499
    Location:203 → 261
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:434 → 494
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  16. XM_011530326.4 → XP_011528628.1  EF-hand calcium-binding domain-containing protein 6 isoform X11

    Conserved Domains (4) summary
    COG5126
    Location:320 → 495
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    pfam08976
    Location:1186 → 1242
    EF-hand_11; EF-hand domain
    pfam13499
    Location:203 → 261
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:434 → 494
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  17. XM_011530328.4 → XP_011528630.1  EF-hand calcium-binding domain-containing protein 6 isoform X13

    Conserved Domains (3) summary
    COG5126
    Location:320 → 495
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    pfam13499
    Location:203 → 261
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:434 → 494
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  18. XM_011530330.4 → XP_011528632.1  EF-hand calcium-binding domain-containing protein 6 isoform X16

    Conserved Domains (3) summary
    COG5126
    Location:320 → 495
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    pfam13499
    Location:203 → 261
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:434 → 494
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  19. XM_047441463.1 → XP_047297419.1  EF-hand calcium-binding domain-containing protein 6 isoform X14

  20. XM_047441465.1 → XP_047297421.1  EF-hand calcium-binding domain-containing protein 6 isoform X17

RNA

  1. XR_007067980.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    44011227..44295198 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054325843.1 → XP_054181818.1  EF-hand calcium-binding domain-containing protein 6 isoform X9

  2. XM_054325838.1 → XP_054181813.1  EF-hand calcium-binding domain-containing protein 6 isoform X5

  3. XM_054325834.1 → XP_054181809.1  EF-hand calcium-binding domain-containing protein 6 isoform X2

  4. XM_054325840.1 → XP_054181815.1  EF-hand calcium-binding domain-containing protein 6 isoform X7

  5. XM_054325841.1 → XP_054181816.1  EF-hand calcium-binding domain-containing protein 6 isoform X7

  6. XM_054325835.1 → XP_054181810.1  EF-hand calcium-binding domain-containing protein 6 isoform X2

  7. XM_054325836.1 → XP_054181811.1  EF-hand calcium-binding domain-containing protein 6 isoform X3

  8. XM_054325837.1 → XP_054181812.1  EF-hand calcium-binding domain-containing protein 6 isoform X4

  9. XM_054325832.1 → XP_054181807.1  EF-hand calcium-binding domain-containing protein 6 isoform X1

  10. XM_054325833.1 → XP_054181808.1  EF-hand calcium-binding domain-containing protein 6 isoform X1

  11. XM_054325844.1 → XP_054181819.1  EF-hand calcium-binding domain-containing protein 6 isoform X10

  12. XM_054325842.1 → XP_054181817.1  EF-hand calcium-binding domain-containing protein 6 isoform X8

  13. XM_054325846.1 → XP_054181821.1  EF-hand calcium-binding domain-containing protein 6 isoform X12

  14. XM_054325849.1 → XP_054181824.1  EF-hand calcium-binding domain-containing protein 6 isoform X15

  15. XM_054325839.1 → XP_054181814.1  EF-hand calcium-binding domain-containing protein 6 isoform X6

  16. XM_054325845.1 → XP_054181820.1  EF-hand calcium-binding domain-containing protein 6 isoform X11

  17. XM_054325847.1 → XP_054181822.1  EF-hand calcium-binding domain-containing protein 6 isoform X13

  18. XM_054325850.1 → XP_054181825.1  EF-hand calcium-binding domain-containing protein 6 isoform X16

  19. XM_054325848.1 → XP_054181823.1  EF-hand calcium-binding domain-containing protein 6 isoform X14

  20. XM_054325851.1 → XP_054181826.1  EF-hand calcium-binding domain-containing protein 6 isoform X17

RNA

  1. XR_008485410.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5THR3.1 GenPept UniProtKB/Swiss-Prot:Q5THR3

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