Tmprss11d transmembrane serine protease 11D [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tmprss11dprovided by RGD
Official Full Name: transmembrane serine protease 11Dprovided by RGD
Primary source: RGD:620654
See related: EnsemblRapid:ENSRNOG00000055991 AllianceGenome:RGD:620654
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Asp
Summary: Enables serine-type peptidase activity. Involved in regulation of growth. Located in cell surface. Orthologous to human TMPRSS11D (transmembrane serine protease 11D). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Adrenal (RPKM 14.1), Testes (RPKM 6.8) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14p21

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (22062129..22124189)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (21707336..21769398)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (23330933..23392993)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results identify a secreted serine protease (adrenal secretory protease) expressed by the adrenal gland, which plays a role in adrenal growth.
Title: Identification of a serine protease involved with the regulation of adrenal growth.
Predominantly expressed in upper gastrointestinal and respiratory tract-but also in adrenal gland. Complex expression pattern. Multifunctional role beyond adrenal proliferation.
Title: The adrenal secretory serine protease AsP is a short secretory isoform of the transmembrane airway trypsin-like protease.

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General gene information

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Markers

Tmprss11d (e-PCR), detects polymorphism
- UniSTS:498752

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type peptidase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	ISO Inferred from Sequence Orthology more info
involved_in regulation of growth	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transmembrane protease serine 11D

Names: AT; adrenal secretory serine protease; airway trypsin-like protease; transmembrane protease, serine 11d

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033652.2 → NP_001028824.2 transmembrane protease serine 11D isoform a

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000014

UniProtKB/Swiss-Prot

Q8VHJ4, Q9QZ74

UniProtKB/TrEMBL

A6JCR3, G3V691

Related

ENSRNOP00000073795.1, ENSRNOT00000088552.3

Conserved Domains (2) summary

cd00190
Location:186 → 414

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

pfam01390
Location:48 → 150

SEA; SEA domain
NM_022630.2 → NP_072152.2 transmembrane protease serine 11D isoform b precursor

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000014

UniProtKB/TrEMBL

A6JCR4

Conserved Domains (1) summary

cd00190
Location:48 → 276

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...