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Eloc elongin C [ Rattus norvegicus (Norway rat) ]

Gene ID: 64525, updated on 27-Nov-2024

Summary

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Official Symbol
Elocprovided by RGD
Official Full Name
elongin Cprovided by RGD
Primary source
RGD:620658
See related
EnsemblRapid:ENSRNOG00000076409 AllianceGenome:RGD:620658
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tceb1
Summary
Predicted to enable protein-macromolecule adaptor activity and transcription corepressor binding activity. Predicted to contribute to ubiquitin-protein transferase activity. Involved in positive regulation of transcription elongation by RNA polymerase II. Part of VCB complex. Orthologous to human ELOC (elongin C). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 150.1), Brain (RPKM 125.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Eloc in Genome Data Viewer
Location:
5q11
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (7444769..7461187)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (2661527..2677893)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (2042991..2059357)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 70 Neighboring gene isopentenyl-diphosphate delta isomerase 1, pseudogene 1 Neighboring gene uncharacterized LOC134486910 Neighboring gene ubiquitin-conjugating enzyme E2W Neighboring gene spindlin-2-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Molecular cloning of an essential subunit of RNA polymerase II elongation factor SIII. Garrett KP, et al. Proc Natl Acad Sci U S A, 1994 Jun 7. PMID 8202474, Free PMC Article
  2. Identification of elongin C sequences required for interaction with the von Hippel-Lindau tumor suppressor protein. Takagi Y, et al. J Biol Chem, 1997 Oct 24. PMID 9341197
  3. RNA polymerase II transcription factor SIII. I. Identification, purification, and properties. Bradsher JN, et al. J Biol Chem, 1993 Dec 5. PMID 8244996
  4. The elongin B ubiquitin homology domain. Identification of Elongin B sequences important for interaction with Elongin C. Brower CS, et al. J Biol Chem, 1999 May 7. PMID 10224134
  5. Regulation of oxygen homeostasis by hypoxia-inducible factor 1. Semenza GL. Physiology (Bethesda), 2009 Apr. PMID 19364912

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC72822

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-macromolecule adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription corepressor binding ISO
Inferred from Sequence Orthology
more info
  
contributes_to ubiquitin-protein transferase activity IC
Inferred by Curator
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of transcription elongation by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in target-directed miRNA degradation ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription initiation at RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Cul5-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
part_of Cul5-RING ubiquitin ligase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of VCB complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of elongin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of elongin complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
elongin-C
Names
RNA polymerase II transcription factor SIII subunit C
SIII p15
elongation factor SIII p15 subunit
elongin 15 kDa subunit
stromal membrane-associated protein SMAP1B homolog
transcription elongation factor B (SIII), polypeptide 1
transcription elongation factor B polypeptide 1
transcription elongation factor B subunit 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270561.2 → NP_001257490.1  elongin-C

    See identical proteins and their annotated locations for NP_001257490.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    P83941
    UniProtKB/TrEMBL
    A0A096MIY6, A6JFA3
    Conserved Domains (1) summary
    cd18321
    Location:18 → 112
    BTB_POZ_EloC; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Elongin-C (EloC) and similar proteins

  2. NM_001270562.2 → NP_001257491.1  elongin-C

    See identical proteins and their annotated locations for NP_001257491.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    P83941
    UniProtKB/TrEMBL
    A0A096MIY6, A6JFA3
    Related
    ENSRNOP00000101569.1, ENSRNOT00000140131.1
    Conserved Domains (1) summary
    cd18321
    Location:18 → 112
    BTB_POZ_EloC; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Elongin-C (EloC) and similar proteins

  3. NM_001270563.2 → NP_001257492.1  elongin-C

    See identical proteins and their annotated locations for NP_001257492.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    P83941
    UniProtKB/TrEMBL
    A0A096MIY6, A6JFA3
    Conserved Domains (1) summary
    cd18321
    Location:18 → 112
    BTB_POZ_EloC; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Elongin-C (EloC) and similar proteins

  4. NM_001430040.1 → NP_001416969.1  elongin-C

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    P83941
    UniProtKB/TrEMBL
    A6JFA3

  5. NM_001430041.1 → NP_001416970.1  elongin-C

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    P83941
    UniProtKB/TrEMBL
    A6JFA3

  6. NM_001430042.1 → NP_001416971.1  elongin-C

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    P83941
    UniProtKB/TrEMBL
    A6JFA3

  7. NM_022593.5 → NP_072115.1  elongin-C

    See identical proteins and their annotated locations for NP_072115.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    P83941
    UniProtKB/TrEMBL
    A0A096MIY6, A6JFA3
    Conserved Domains (1) summary
    cd18321
    Location:18 → 112
    BTB_POZ_EloC; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Elongin-C (EloC) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    7444769..7461187
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006237724.5 → XP_006237786.1  elongin-C isoform X1

    Conserved Domains (1) summary
    cd18321
    Location:18 → 112
    BTB_POZ_EloC; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Elongin-C (EloC) and similar proteins

  2. XM_039110711.2 → XP_038966639.1  elongin-C isoform X1

    UniProtKB/Swiss-Prot
    P83941
    UniProtKB/TrEMBL
    A0A096MIY6, A6JFA3
    Conserved Domains (1) summary
    cd18321
    Location:18 → 112
    BTB_POZ_EloC; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Elongin-C (EloC) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P83941.1 GenPept UniProtKB/Swiss-Prot:P83941

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