Aldh1l1 aldehyde dehydrogenase 1 family, member L1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Aldh1l1provided by RGD
Official Full Name: aldehyde dehydrogenase 1 family, member L1provided by RGD
Primary source: RGD:621294
See related: EnsemblRapid:ENSRNOG00000047023 AllianceGenome:RGD:621294
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: FDH; Fthfd
Summary: Enables aldehyde dehydrogenase (NADP+) activity and formyltetrahydrofolate dehydrogenase activity. Involved in 10-formyltetrahydrofolate catabolic process; NADPH regeneration; and folic acid metabolic process. Located in cytosol. Part of protein-containing complex. Biomarker of cholestasis. Orthologous to human ALDH1L1 (aldehyde dehydrogenase 1 family member L1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Liver (RPKM 1007.9), Kidney (RPKM 533.8) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q34

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (124617182..124663674)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (123059989..123106471)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (123516553..123564067, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A Paternal Methylation Error in the Congenital Hydrocephalic Texas (H-Tx) Rat Is Partially Rescued with Natural Folate Supplements.
Title: A Paternal Methylation Error in the Congenital Hydrocephalic Texas (H-Tx) Rat Is Partially Rescued with Natural Folate Supplements.
Structure of putative tumor suppressor ALDH1L1.
Title: Structure of putative tumor suppressor ALDH1L1.
catalytic mechanism for the hydrolase reaction in which Asp-142 polarizes the catalytic water molecule and His-106 orients the carbonyl group of formyl.
Title: The crystal structure of the hydrolase domain of 10-formyltetrahydrofolate dehydrogenase: mechanism of hydrolysis and its interplay with the dehydrogenase domain.
Upon binding of NADP+, side chain of Glu673 is displaced from the active site by the nicotinamide ring & contacts a chain of highly ordered water molecules that may represent a pathway for translocation of the abstracted proton from Glu673 to the solvent.
Title: Crystal structures of the carboxyl terminal domain of rat 10-formyltetrahydrofolate dehydrogenase: implications for the catalytic mechanism of aldehyde dehydrogenases.

Submit: New GeneRIF Correction

General gene information

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Markers

AU027055 (e-PCR)
- UniSTS:113675

BI284419 (e-PCR)
- UniSTS:244116

RH127817 (e-PCR)
- UniSTS:211127

Aldh1l1 (e-PCR), detects polymorphism
- UniSTS:526033

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables aldehyde dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables aldehyde dehydrogenase (NADP+) activity	IDA Inferred from Direct Assay more info	PubMed
enables aldehyde dehydrogenase [NAD(P)+] activity	IDA Inferred from Direct Assay more info	PubMed
enables formyltetrahydrofolate dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables formyltetrahydrofolate dehydrogenase activity	IDA Inferred from Direct Assay more info	PubMed
enables formyltetrahydrofolate dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables formyltetrahydrofolate dehydrogenase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables formyltetrahydrofolate dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables formyltetrahydrofolate dehydrogenase activity	TAS Traceable Author Statement more info	PubMed
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in 10-formyltetrahydrofolate catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in 10-formyltetrahydrofolate catabolic process	IEA Inferred from Electronic Annotation more info
involved_in 10-formyltetrahydrofolate catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in 10-formyltetrahydrofolate catabolic process	ISO Inferred from Sequence Orthology more info
involved_in NADPH regeneration	IDA Inferred from Direct Assay more info	PubMed
involved_in NADPH regeneration	IEA Inferred from Electronic Annotation more info
involved_in NADPH regeneration	ISO Inferred from Sequence Orthology more info
involved_in biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in folic acid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in one-carbon metabolic process	IEA Inferred from Electronic Annotation more info
involved_in tetrahydrofolate biosynthetic process	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cytosolic 10-formyltetrahydrofolate dehydrogenase

Names: 10-FTHFDH; 10-formyltetrahydrofolate dehydrogenase; FBP-CI; aldehyde dehydrogenase family 1 member L1; formyltetrahydrofolate dehydrogenase

NP_071992.2

EC 1.5.1.6

XP_038964247.1

EC 1.5.1.6

XP_063142735.1

EC 1.5.1.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022547.2 → NP_071992.2 cytosolic 10-formyltetrahydrofolate dehydrogenase

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/Swiss-Prot

P28037, Q5HZB2

UniProtKB/TrEMBL

A0A0G2K0D8

Related

ENSRNOP00000065882.4, ENSRNOT00000075042.4

Conserved Domains (3) summary

cd07140
Location:417 → 902

ALDH_F1L_FTFDH; 10-formyltetrahydrofolate dehydrogenase, ALDH family 1L

cd08647
Location:1 → 203

FMT_core_FDH_N; 10-formyltetrahydrofolate dehydrogenase (FDH), N-terminal hydrolase domain

cd08703
Location:206 → 306

FDH_Hydrolase_C; The C-terminal subdomain of the hydrolase domain on the bi-functional protein 10-formyltetrahydrofolate dehydrogenase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

124617182..124663674

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063286665.1 → XP_063142735.1 cytosolic 10-formyltetrahydrofolate dehydrogenase isoform X1

UniProtKB/TrEMBL

A0A8I6GG93
XM_039108319.2 → XP_038964247.1 cytosolic 10-formyltetrahydrofolate dehydrogenase isoform X2

UniProtKB/TrEMBL

A0A0G2K0D8

Conserved Domains (3) summary

cd08647
Location:1 → 203

FMT_core_FDH_N; 10-formyltetrahydrofolate dehydrogenase (FDH), N-terminal hydrolase domain

cd08703
Location:206 → 306

FDH_Hydrolase_C; The C-terminal subdomain of the hydrolase domain on the bi-functional protein 10-formyltetrahydrofolate dehydrogenase

cl11961
Location:417 → 782

ALDH-SF; NAD(P)+-dependent aldehyde dehydrogenase superfamily