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Prpsap1 phosphoribosyl pyrophosphate synthetase-associated protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 64390, updated on 27-Nov-2024

Summary

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Official Symbol
Prpsap1provided by RGD
Official Full Name
phosphoribosyl pyrophosphate synthetase-associated protein 1provided by RGD
Primary source
RGD:620206
See related
EnsemblRapid:ENSRNOG00000010083 AllianceGenome:RGD:620206
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables enzyme regulator activity and kinase binding activity. Involved in negative regulation of kinase activity. Part of ribose phosphate diphosphokinase complex. Orthologous to human PRPSAP1 (phosphoribosyl pyrophosphate synthetase associated protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 202.5), Adrenal (RPKM 164.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Prpsap1 in Genome Data Viewer
Location:
10q32.1
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (102199949..102221642, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (101701094..101750753, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (105430516..105492154, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene UBA-like domain containing 2 Neighboring gene glutamine rich 2 Neighboring gene sphk1a antisense transcript Neighboring gene sphingosine kinase 1 Neighboring gene ubiquitin-conjugating enzyme E2O Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Promoter region of the rat phosphoribosylpyrophosphate synthetase-associated protein 39. Ishizuka T, et al. Biochim Biophys Acta, 1996 Apr 10. PMID 8611622
  2. Rat liver phosphoribosyl pyrophosphate synthetase: existence of the purified enzyme as heterogeneous aggregates and identification of the catalytic subunit. Kita K, et al. J Biochem, 1989 May. PMID 2546925
  3. Partial reconstitution of mammalian phosphoribosylpyrophosphate synthetase in Escherichia coli cells. Coexpression of catalytic subunits with the 39-kDa associated protein leads to formation of soluble multimeric complexes of various compositions. Ishijima S, et al. Biochim Biophys Acta, 1997 Sep 26. PMID 9366267
  4. Shifted Transversal Design smart-pooling for high coverage interactome mapping. Xin X, et al. Genome Res, 2009 Jul. PMID 19447967, Free PMC Article
  5. A novel 39-kDa phosphoribosylpyrophosphate synthetase-associated protein of rat liver. Cloning, high sequence similarity to the catalytic subunits, and a negative regulatory role. Kita K, et al. J Biol Chem, 1994 Mar 18. PMID 8132556

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables enzyme regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables enzyme regulator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 5-phosphoribose 1-diphosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in purine nucleotide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ribose phosphate diphosphokinase complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
phosphoribosyl pyrophosphate synthase-associated protein 1
Names
39 kDa phosphoribosypyrophosphate synthase-associated protein
39 kDa phosphoribosypyrophosphate synthetase-associated protein
PAP39
PRPP synthase-associated protein 1
PRPP synthetase-associated protein 1
phosphoribosylpyrophosphate synthetase-associated protein (39 kDa)
NP_071990.2
XP_038942719.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022545.3 → NP_071990.2  phosphoribosyl pyrophosphate synthase-associated protein 1

    See identical proteins and their annotated locations for NP_071990.2

    Status: VALIDATED

    Source sequence(s)
    BC078822, CB736123
    UniProtKB/Swiss-Prot
    Q63417, Q63468
    UniProtKB/TrEMBL
    A6HKW7, G3V7B5, Q6AYZ7
    Related
    ENSRNOP00000013573.4, ENSRNOT00000013573.7
    Conserved Domains (2) summary
    pfam13793
    Location:38 → 155
    Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase
    pfam14572
    Location:196 → 379
    Pribosyl_synth; Phosphoribosyl synthetase-associated domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    102199949..102221642 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039086791.2 → XP_038942719.1  phosphoribosyl pyrophosphate synthase-associated protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZZP2
    Conserved Domains (2) summary
    pfam13793
    Location:1 → 52
    Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase
    pfam14572
    Location:93 → 276
    Pribosyl_synth; Phosphoribosyl synthetase-associated domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q63468.1 GenPept UniProtKB/Swiss-Prot:Q63468

Gene LinkOut

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