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Cd151 CD151 molecule (Raph blood group) [ Rattus norvegicus (Norway rat) ]

Gene ID: 64315, updated on 27-Nov-2024

Summary

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Symbol
Cd151provided by RGD
Full Name
CD151 molecule (Raph blood group)provided by RGD
Primary source
RGD:621290
See related
EnsemblRapid:ENSRNOG00000062573 AllianceGenome:RGD:621290
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables integrin binding activity. Predicted to be involved in cell migration. Predicted to act upstream of or within several processes, including T cell proliferation; positive regulation of endocytosis; and wound healing, spreading of cells. Predicted to be located in basement membrane and cell surface. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in epidermolysis bullosa simplex. Orthologous to human CD151 (CD151 molecule (Raph blood group)). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 798.4), Heart (RPKM 716.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cd151 in Genome Data Viewer
Location:
1q41
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (205994300..205998307)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (196564744..196568753)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (214446659..214450668)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene patatin-like phospholipase domain containing 2 Neighboring gene calcium release activated channel regulator 2B Neighboring gene RNA polymerase II, I and III subunit L Neighboring gene tetraspanin 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. CD151 Alleviates Early Blood-Brain Barrier Dysfunction After Experimental Focal Brain Ischemia in Rats. Xu W, et al. Cell Mol Neurobiol, 2021 Jan. PMID 32285246
  2. Tetraspan protein CD151: a common target of mood stabilizing drugs? Hua LV, et al. Neuropsychopharmacology, 2001 Nov. PMID 11682256
  3. The tetraspanin CD151 functions as a negative regulator in the adhesion-dependent activation of Ras. Sawada S, et al. J Biol Chem, 2003 Jul 18. PMID 12782641
  4. The tetraspanins CD151 and Tspan8 are essential exosome components for the crosstalk between cancer initiating cells and their surrounding. Yue S, et al. Oncotarget, 2015 Feb 10. PMID 25544774, Free PMC Article
  5. Tspan8 and CD151 promote metastasis by distinct mechanisms. Yue S, et al. Eur J Cancer, 2013 Sep. PMID 23683890

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Downregulation of CD151 restricts VCAM-1 mediated leukocyte infiltration to reduce neurobiological injuries after experimental stroke.
    Title: Downregulation of CD151 restricts VCAM-1 mediated leukocyte infiltration to reduce neurobiological injuries after experimental stroke.
  2. CD151 Alleviates Early Blood-Brain Barrier Dysfunction After Experimental Focal Brain Ischemia in Rats.
    Title: CD151 Alleviates Early Blood-Brain Barrier Dysfunction After Experimental Focal Brain Ischemia in Rats.
  3. Overexpression of Cd151 blocks the activating effect of miR-199a-3p on cardiomyocyte proliferation, suggesting Cd151 is a functional target of miR-199a-3p in cardiomyocytes.
    Title: miR-199a-3p promotes cardiomyocyte proliferation by inhibiting Cd151 expression.
  4. Data indicate that the major contribution of cellular tetraspanins CD151 and Tspan8 to lymphatic metastasis formation relies on promoting motility and invasiveness.
    Title: The tetraspanins CD151 and Tspan8 are essential exosome components for the crosstalk between cancer initiating cells and their surrounding.
  5. CD151 and Tspan8 coordinately promote metastasis, where Tspan8 overrides the adhesive features of CD151 by recruiting integrins out of adhesion into motility promoting complexes.
    Title: Tspan8 and CD151 promote metastasis by distinct mechanisms.
  6. Expression of CD151 specifically attenuated adhesion-dependent activation of Ras.
    Title: The tetraspanin CD151 functions as a negative regulator in the adhesion-dependent activation of Ras.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables integrin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables integrin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within T cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell migration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of endocytosis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within wound healing, spreading of cells ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in basement membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
CD151 antigen
Names
CD151 antigen (Raph blood group)
CD151 antigen-like
PETA-3
platelet-endothelial tetraspan antigen 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022523.1 → NP_071968.1  CD151 antigen

    See identical proteins and their annotated locations for NP_071968.1

    Status: PROVISIONAL

    Source sequence(s)
    AF192547
    UniProtKB/Swiss-Prot
    Q9QZA6
    UniProtKB/TrEMBL
    A0A8I6AQJ7, A6HXZ8
    Conserved Domains (2) summary
    cd03155
    Location:112 → 220
    CD151_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
    pfam00335
    Location:16 → 244
    Tetraspannin; Tetraspanin family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    205994300..205998307
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006230576.5 → XP_006230638.1  CD151 antigen isoform X1

    See identical proteins and their annotated locations for XP_006230638.1

    UniProtKB/Swiss-Prot
    Q9QZA6
    UniProtKB/TrEMBL
    A0A8I6AQJ7, A6HXZ8
    Related
    ENSRNOP00000096244.2, ENSRNOT00000107678.2
    Conserved Domains (2) summary
    cd03155
    Location:112 → 220
    CD151_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
    pfam00335
    Location:16 → 244
    Tetraspannin; Tetraspanin family

  2. XM_017589658.3 → XP_017445147.1  CD151 antigen isoform X1

    UniProtKB/Swiss-Prot
    Q9QZA6
    UniProtKB/TrEMBL
    A0A8I6AQJ7, A6HXZ8
    Conserved Domains (2) summary
    cd03155
    Location:112 → 220
    CD151_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
    pfam00335
    Location:16 → 244
    Tetraspannin; Tetraspanin family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QZA6.2 GenPept UniProtKB/Swiss-Prot:Q9QZA6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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