arnt2 aryl-hydrocarbon receptor nuclear translocator 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: arnt2provided by ZNC
Official Full Name: aryl-hydrocarbon receptor nuclear translocator 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-001207-3
See related: Ensembl:ENSDARG00000103697 AllianceGenome:ZFIN:ZDB-GENE-001207-3
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: Arnt; arnt2X; arnt2a; zfARNT2; zfARNT2a; zfARNT2b; zfARNT2c; chunp6921
Summary: Enables DNA-binding transcription factor activity. Involved in regulation of DNA-templated transcription; response to hypoxia; and signal transduction. Acts upstream of or within several processes, including nervous system development; positive regulation of hypoxia-inducible factor-1alpha signaling pathway; and swim bladder inflation. Predicted to be located in cytoplasm. Predicted to be part of aryl hydrocarbon receptor complex. Predicted to be active in nucleus. Is expressed in several structures, including gut; hatching gland; mandibular arch skeleton; nervous system; and vasculature. Orthologous to human ARNT2 (aryl hydrocarbon receptor nuclear translocator 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (10701728..10877530)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (10459172..10631952)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hemato-vascular specification requires arnt1 and arnt2 genes in zebrafish embryos.
Title: Hemato-vascular specification requires arnt1 and arnt2 genes in zebrafish embryos.
Arnt2 contributes to control of lateral positioning of longitudinal hypothalamic-spinal axons by negative regulation of robo3a.1 expression, which in turn attenuates the repulsive activity of Robo2.
Title: Sim1a and Arnt2 contribute to hypothalamo-spinal axon guidance by regulating Robo2 activity via a Robo3-dependent mechanism.
The only effect in arnt2(-/-) larvae that occurred before 120 hours postfertilization (hpf) was a decrease in expression of sim1, an Arnt2 dimerization partner, in the hypothalamus and ventral thalamus at 72 hpf.
Title: Potential roles of Arnt2 in zebrafish larval development.
Zebrafish gene (zfARNT2) is not essential for mediating TCDD developmental toxicity in zebrafish.
Title: ARNT2 is not required for TCDD developmental toxicity in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in brain development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cardiac ventricle morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within diencephalon development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dopaminergic neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hypothalamus cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within liver morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IPI Inferred from Physical Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of hypoxia-inducible factor-1alpha signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to hypoxia	IDA Inferred from Direct Assay more info
involved_in signal transduction	IDA Inferred from Direct Assay more info
acts_upstream_of_or_within swim bladder inflation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ventricular system development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of aryl hydrocarbon receptor complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IC Inferred by Curator more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of transcription regulator complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: aryl hydrocarbon receptor nuclear translocator 2

Names: ARNT protein 2; Ah receptor nuclear translocator; unm t30256; unm_t30256

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131674.1 → NP_571749.1 aryl hydrocarbon receptor nuclear translocator 2

See identical proteins and their annotated locations for NP_571749.1

Status: PROVISIONAL

Source sequence(s)

AF219988

UniProtKB/Swiss-Prot

Q9DG11, Q9DG12, Q9DG13, Q9IAS2

Related

ENSDARP00000136894.1, ENSDART00000158162.2

Conserved Domains (5) summary

smart00091
Location:155 → 219

PAS; PAS domain

cd00130
Location:351 → 447

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam00010
Location:80 → 132

HLH; Helix-loop-helix DNA-binding domain

pfam00989
Location:152 → 258

PAS; PAS fold

pfam14598
Location:351 → 451

PAS_11; PAS domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007118.7 Reference GRCz11 Primary Assembly

Range

10701728..10877530

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009302938.4 → XP_009301213.1 aryl hydrocarbon receptor nuclear translocator 2 isoform X1

UniProtKB/Swiss-Prot

Q9DG11, Q9DG12, Q9DG13, Q9IAS2

UniProtKB/TrEMBL

A0A8M3ATW0

Conserved Domains (5) summary

smart00091
Location:155 → 219

PAS; PAS domain

cd00130
Location:351 → 447

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam00010
Location:80 → 132

HLH; Helix-loop-helix DNA-binding domain

pfam00989
Location:152 → 258

PAS; PAS fold

pfam14598
Location:351 → 451

PAS_11; PAS domain
XM_009302939.4 → XP_009301214.1 aryl hydrocarbon receptor nuclear translocator 2 isoform X2

UniProtKB/Swiss-Prot

Q9DG11, Q9DG12, Q9DG13, Q9IAS2

UniProtKB/TrEMBL

A0A8M3B3V4

Conserved Domains (5) summary

smart00091
Location:140 → 204

PAS; PAS domain

cd00130
Location:336 → 432

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam00010
Location:65 → 117

HLH; Helix-loop-helix DNA-binding domain

pfam00989
Location:137 → 243

PAS; PAS fold

pfam14598
Location:336 → 436

PAS_11; PAS domain
XM_009302940.4 → XP_009301215.1 aryl hydrocarbon receptor nuclear translocator 2 isoform X3

UniProtKB/Swiss-Prot

Q9DG11, Q9DG12, Q9DG13, Q9IAS2

UniProtKB/TrEMBL

A0A0R4ID51, A0A8M3B0Y7

Related

ENSDARP00000131846.1, ENSDART00000167323.2

Conserved Domains (5) summary

smart00091
Location:140 → 204

PAS; PAS domain

cd00130
Location:336 → 432

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam00010
Location:65 → 117

HLH; Helix-loop-helix DNA-binding domain

pfam00989
Location:137 → 243

PAS; PAS fold

pfam14598
Location:336 → 436

PAS_11; PAS domain