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Ube2d2 ubiquitin-conjugating enzyme E2D 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 641452, updated on 27-Nov-2024

Summary

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Official Symbol
Ube2d2provided by RGD
Official Full Name
ubiquitin-conjugating enzyme E2D 2provided by RGD
Primary source
RGD:1591897
See related
EnsemblRapid:ENSRNOG00000069286 AllianceGenome:RGD:1591897
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ubc2e; E217kB
Summary
Enables ubiquitin-protein transferase activity. Predicted to be involved in protein K48-linked ubiquitination; protein autoubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Orthologous to human UBE2D2 (ubiquitin conjugating enzyme E2 D2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 387.1), Thymus (RPKM 315.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ube2d2 in Genome Data Viewer
Location:
18p11
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (27638399..27680386)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (27364325..27406322)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (28561957..28603335)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120098144 Neighboring gene stimulator of interferon response cGAMP interactor 1 Neighboring gene U6atac minor spliceosomal RNA Neighboring gene CXXC finger protein 5 Neighboring gene uncharacterized LOC134482928 Neighboring gene ribosomal protein S16, pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. UBE2D2 is not involved in MuRF1-dependent muscle wasting during hindlimb suspension. Polge C, et al. Int J Biochem Cell Biol, 2016 Oct. PMID 27378730
  2. A novel rat homolog of the Saccharomyces cerevisiae ubiquitin-conjugating enzymes UBC4 and UBC5 with distinct biochemical features is induced during spermatogenesis. Wing SS, et al. Mol Cell Biol, 1996 Aug. PMID 8754804, Free PMC Article
  3. Molecular cloning, expression and characterization of a ubiquitin conjugation enzyme (E2(17)kB) highly expressed in rat testis. Wing SS, et al. Biochem J, 1995 Jan 1. PMID 7826319, Free PMC Article
  4. Ubiquitin-conjugating enzyme UBE2D2 is responsible for FBXW2 (F-box and WD repeat domain containing 2)-mediated human GCM1 (glial cell missing homolog 1) ubiquitination and degradation. Chiang MH, et al. Biol Reprod, 2008 Nov. PMID 18703417
  5. Members of the E2D (UbcH5) family mediate the ubiquitination of the conserved cysteine of Pex5p, the peroxisomal import receptor. Grou CP, et al. J Biol Chem, 2008 May 23. PMID 18359941

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. UBE2D2 is not the cognate ubiquitinating enzyme for MuRF1
    Title: UBE2D2 is not involved in MuRF1-dependent muscle wasting during hindlimb suspension.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin conjugating enzyme activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in protein K48-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K48-linked ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein autoubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ubiquitin-conjugating enzyme E2 D2
Names
(E3-independent) E2 ubiquitin-conjugating enzyme D2
E2 ubiquitin-conjugating enzyme D2
E2(17)KB 2
ubc2e ubiquitin conjugating enzyme
ubiquitin carrier protein D2
ubiquitin-conjugating enzyme E2(17)KB 2
ubiquitin-conjugating enzyme E2-17 kDa 2
ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)
ubiquitin-protein ligase D2
NP_001380701.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001393772.1 → NP_001380701.1  ubiquitin-conjugating enzyme E2 D2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/Swiss-Prot
    P62839
    UniProtKB/TrEMBL
    A0A0G2K739, A6J2Z6
    Related
    ENSRNOP00000088484.2, ENSRNOT00000095794.2
    Conserved Domains (1) summary
    cl00154
    Location:1 → 146
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    27638399..27680386
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001037292.1: Suppressed sequence

    Description
    NM_001037292.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P62839.1 GenPept UniProtKB/Swiss-Prot:P62839

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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