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tubb2b tubulin, beta 2b [ Danio rerio (zebrafish) ]

Gene ID: 641421, updated on 9-Dec-2024

Summary

Official Symbol
tubb2bprovided by ZNC
Official Full Name
tubulin, beta 2bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-722
See related
Ensembl:ENSDARG00000098591 AllianceGenome:ZFIN:ZDB-GENE-030131-722
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fb40f09; wu:fb40f09; zgc:123194
Summary
Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in microtubule cytoskeleton organization and mitotic cell cycle. Predicted to act upstream of or within microtubule-based process. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm and microtubule. Human ortholog(s) of this gene implicated in Leber congenital amaurosis with early-onset deafness and complex cortical dysplasia with other brain malformations 7. Orthologous to several human genes including TUBB4B (tubulin beta 4B class IVb). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See tubb2b in Genome Data Viewer
Location:
chromosome: 8
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (52713232..52715911, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (52726939..52729618, complement)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene si:dkey-90l8.3 Neighboring gene BCL2 like 16 Neighboring gene fibroblast growth factor 17 Neighboring gene adhesion G protein-coupled receptor D2

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

General gene information

Clone Names

  • MGC123194

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables GTP binding  
enables GTPase activity  
enables nucleotide binding  
enables structural constituent of cytoskeleton  
Component Evidence Code Pubs
located_in cytoplasm  
located_in cytoskeleton  
located_in microtubule  

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037410.2 → NP_001032487.2  tubulin beta-2b chain

    Status: VALIDATED

    Source sequence(s)
    CU984584
    UniProtKB/TrEMBL
    A0A8M1N7Z8
    Related
    ENSDARP00000137515.1, ENSDART00000168241.2
    Conserved Domains (2) summary
    PLN00220
    Location:28 → 457
    PLN00220; tubulin beta chain; Provisional
    cd02187
    Location:29 → 453
    beta_tubulin; The beta-tubulin family

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    52713232..52715911 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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