Sdf2l1 stromal cell-derived factor 2-like 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sdf2l1provided by MGI
Official Full Name: stromal cell-derived factor 2-like 1provided by MGI
Primary source: MGI:MGI:2149842
See related: Ensembl:ENSMUSG00000022769 AllianceGenome:MGI:2149842
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable ATPase binding activity; misfolded protein binding activity; and protein-folding chaperone binding activity. Predicted to be involved in chaperone cofactor-dependent protein refolding. Predicted to act upstream of or within ERAD pathway; cellular response to misfolded protein; and regulation of apoptotic process. Part of endoplasmic reticulum chaperone complex. Is expressed in ventricular layer. Orthologous to human SDF2L1 (stromal cell derived factor 2 like 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in ovary adult (RPKM 56.1), colon adult (RPKM 48.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 A3; 16 10.62 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (16948002..16950247, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (17130138..17132383, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In obese and diabetic mice, Sdf2l1 is downregulated due to decreased levels of nuclear XBP-1s, whereas restoration of Sdf2l1 expression ameliorates glucose intolerance and fatty liver with decreased ER stress.
Title: Hepatic Sdf2l1 controls feeding-induced ER stress and regulates metabolism.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATPase binding	ISO Inferred from Sequence Orthology more info	PubMed
enables misfolded protein binding	ISO Inferred from Sequence Orthology more info	PubMed
enables protein-folding chaperone binding	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within ERAD pathway	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within cellular response to misfolded protein	ISO Inferred from Sequence Orthology more info	PubMed
involved_in chaperone cofactor-dependent protein refolding	IEA Inferred from Electronic Annotation more info
involved_in chaperone cofactor-dependent protein refolding	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of apoptotic process	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISA Inferred from Sequence Alignment more info	PubMed
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info	PubMed
part_of endoplasmic reticulum chaperone complex	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum lumen	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info	PubMed
part_of protein folding chaperone complex	IEA Inferred from Electronic Annotation more info
part_of protein folding chaperone complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: stromal cell-derived factor 2-like protein 1

Names: SDF2-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022324.3 → NP_071719.1 stromal cell-derived factor 2-like protein 1 precursor

See identical proteins and their annotated locations for NP_071719.1

Status: VALIDATED

Source sequence(s)

BC053425, BY253823

Consensus CDS

CCDS37270.1

UniProtKB/Swiss-Prot

Q9ESP1, Q9ESP2

Related

ENSMUSP00000023453.8, ENSMUST00000023453.10

Conserved Domains (2) summary

smart00472
Location:95 → 150

MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases

cl19745
Location:159 → 201

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor