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Fbxl20 F-box and leucine-rich repeat protein 20 [ Rattus norvegicus (Norway rat) ]

Gene ID: 64039, updated on 4-Jan-2025

Summary

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Official Symbol
Fbxl20provided by RGD
Official Full Name
F-box and leucine-rich repeat protein 20provided by RGD
Primary source
RGD:621722
See related
EnsemblRapid:ENSRNOG00000083773 AllianceGenome:RGD:621722
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Fbl2; Fbxl2
Summary
Predicted to be involved in regulation of protein catabolic process at presynapse, modulating synaptic transmission and regulation of synaptic vesicle exocytosis. Predicted to act upstream of or within behavioral fear response. Predicted to be located in presynapse. Predicted to be active in Schaffer collateral - CA1 synapse; cytoplasm; and glutamatergic synapse. Orthologous to human FBXL20 (F-box and leucine rich repeat protein 20). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Adrenal (RPKM 53.6), Lung (RPKM 47.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Fbxl20 in Genome Data Viewer
Location:
10q31
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (83577038..83640022, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (83080568..83143680, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (86036745..86099699, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene SH3 and cysteine rich domain 2 Neighboring gene uncharacterized LOC102548674 Neighboring gene mediator complex subunit 1 Neighboring gene cyclin-dependent kinase 12

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. FBXL20 promotes synaptic impairment in depression disorder via degrading vesicle-associated proteins. Wang W, et al. J Affect Disord, 2024 Mar 15. PMID 38211741
  2. Synaptic E3 ligase SCRAPPER in contextual fear conditioning: extensive behavioral phenotyping of Scrapper heterozygote and overexpressing mutant mice. Yao I, et al. PLoS One, 2011 Feb 24. PMID 21390313, Free PMC Article
  3. Identification of a novel Skp2-like mammalian protein containing F-box and leucine-rich repeats. Ilyin GP, et al. FEBS Lett, 1999 Oct 1. PMID 10508920
  4. SCRAPPER-dependent ubiquitination of active zone protein RIM1 regulates synaptic vesicle release. Yao I, et al. Cell, 2007 Sep 7. PMID 17803915, Free PMC Article
  5. Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system. Ebstein F, et al. Int J Biochem Cell Biol, 2009 May. PMID 19028597

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FBXL20 promotes synaptic impairment in depression disorder via degrading vesicle-associated proteins.
    Title: FBXL20 promotes synaptic impairment in depression disorder via degrading vesicle-associated proteins.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in behavioral fear response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within behavioral fear response ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein catabolic process at presynapse, modulating synaptic transmission IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein catabolic process at presynapse, modulating synaptic transmission ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of synaptic vesicle exocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of synaptic vesicle exocytosis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Schaffer collateral - CA1 synapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in Schaffer collateral - CA1 synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in presynapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
F-box/LRR-repeat protein 20
Names
F-box protein FBL2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001401500.2 → NP_001388429.1  F-box/LRR-repeat protein 20

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A0H2UI14, A0A8I6AIN4
    Related
    ENSRNOP00000103590.1, ENSRNOT00000140962.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    83577038..83640022 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039086778.2 → XP_038942706.1  F-box/LRR-repeat protein 20 isoform X5

    UniProtKB/TrEMBL
    A0A0H2UI14, A6HIQ3
    Related
    ENSRNOP00000110960.1, ENSRNOT00000171192.1
    Conserved Domains (3) summary
    cd09293
    Location:222 → 396
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:121 → 146
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:30 → 71
    F-box-like

  2. XM_039086781.2 → XP_038942709.1  F-box/LRR-repeat protein 20 isoform X7

    UniProtKB/TrEMBL
    A0A0H2UI14
    Conserved Domains (3) summary
    cd09293
    Location:206 → 380
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:105 → 130
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:14 → 55
    F-box-like

  3. XM_017597519.3 → XP_017453008.1  F-box/LRR-repeat protein 20 isoform X2

    UniProtKB/TrEMBL
    A0A0H2UI14, A0A8I6A9E5
    Related
    ENSRNOP00000102976.1, ENSRNOT00000146752.1

  4. XM_039086782.2 → XP_038942710.1  F-box/LRR-repeat protein 20 isoform X7

    UniProtKB/TrEMBL
    A0A0H2UI14
    Conserved Domains (3) summary
    cd09293
    Location:206 → 380
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:105 → 130
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:14 → 55
    F-box-like

  5. XM_039086780.2 → XP_038942708.1  F-box/LRR-repeat protein 20 isoform X7

    UniProtKB/TrEMBL
    A0A0H2UI14
    Related
    ENSRNOP00000109320.1, ENSRNOT00000142853.1
    Conserved Domains (3) summary
    cd09293
    Location:206 → 380
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:105 → 130
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:14 → 55
    F-box-like

  6. XM_063269799.1 → XP_063125869.1  F-box/LRR-repeat protein 20 isoform X3

  7. XM_063269801.1 → XP_063125871.1  F-box/LRR-repeat protein 20 isoform X6

  8. XM_063269800.1 → XP_063125870.1  F-box/LRR-repeat protein 20 isoform X4

  9. XM_063269798.1 → XP_063125868.1  F-box/LRR-repeat protein 20 isoform X1

  10. XM_063269804.1 → XP_063125874.1  F-box/LRR-repeat protein 20 isoform X6

  11. XM_063269802.1 → XP_063125872.1  F-box/LRR-repeat protein 20 isoform X6

  12. XM_063269803.1 → XP_063125873.1  F-box/LRR-repeat protein 20 isoform X8

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_022272.1: Suppressed sequence

    Description
    NM_022272.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QZH7.1 GenPept UniProtKB/Swiss-Prot:Q9QZH7

Gene LinkOut

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