U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Qtrt1 queuine tRNA-ribosyltransferase catalytic subunit 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 64016, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
Qtrt1provided by RGD
Official Full Name
queuine tRNA-ribosyltransferase catalytic subunit 1provided by RGD
Primary source
RGD:620996
See related
AllianceGenome:RGD:620996
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tgt; Tgut
Summary
Predicted to enable protein heterodimerization activity; protein homodimerization activity; and tRNA-guanosine(34) queuine transglycosylase activity. Predicted to be involved in tRNA-guanine transglycosylation. Predicted to be located in cytoplasmic side of mitochondrial outer membrane and nucleus. Predicted to be part of tRNA-guanine transglycosylase complex. Orthologous to human QTRT1 (queuine tRNA-ribosyltransferase catalytic subunit 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Adrenal (RPKM 32.8), Spleen (RPKM 24.7) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Qtrt1 in Genome Data Viewer
Location:
8q13
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (28239993..28249983)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (19965801..19973843)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (22447057..22454328)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 44 member 2 Neighboring gene interleukin enhancer binding factor 3 Neighboring gene dynamin 2 Neighboring gene uncharacterized LOC134480146 Neighboring gene similar to human chromosome 19 open reading frame 38 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class X, pseudogene 1 Neighboring gene transmembrane p24 trafficking protein 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Transfer ribonucleic acid guanine transglycosylase isolated from rat liver. Shindo-Okada N, et al. Biochemistry, 1980 Jan 22. PMID 6986171
  2. Characterization of the human tRNA-guanine transglycosylase: confirmation of the heterodimeric subunit structure. Chen YC, et al. RNA, 2010 May. PMID 20354154, Free PMC Article
  3. Queuosine formation in eukaryotic tRNA occurs via a mitochondria-localized heteromeric transglycosylase. Boland C, et al. J Biol Chem, 2009 Jul 3. PMID 19414587, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein heterodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables tRNA-guanosine(34) queuine transglycosylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA-guanosine(34) queuine transglycosylase activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA-guanosine(34) queuine transglycosylase activity ISO
Inferred from Sequence Orthology
more info
  
enables tRNA-guanosine(34) queuine transglycosylase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables tRNA-guanosine(34) queuine transglycosylase activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in tRNA-guanine transglycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA-guanine transglycosylation IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA-guanine transglycosylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic side of mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic side of mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
part_of tRNA-guanine transglycosylase complex IEA
Inferred from Electronic Annotation
more info
  
part_of tRNA-guanine transglycosylase complex ISO
Inferred from Sequence Orthology
more info
  
part_of transferase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
queuine tRNA-ribosyltransferase catalytic subunit 1
Names
guanine insertion enzyme
queuine tRNA-ribosyltransferase 1
tRNA-guanine transglycosylase
NP_071586.2
XP_038937997.1
XP_038937998.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022250.2 → NP_071586.2  queuine tRNA-ribosyltransferase catalytic subunit 1

    See identical proteins and their annotated locations for NP_071586.2

    Status: VALIDATED

    Source sequence(s)
    BC097321
    UniProtKB/Swiss-Prot
    Q4QR99, Q9JMA0
    UniProtKB/TrEMBL
    A0A0H2UHF3
    Conserved Domains (1) summary
    pfam01702
    Location:26 → 381
    TGT; Queuine tRNA-ribosyltransferase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    28239993..28249983
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039082069.2 → XP_038937997.1  queuine tRNA-ribosyltransferase catalytic subunit 1 isoform X1

    UniProtKB/TrEMBL
    A0A0H2UHF3
    Conserved Domains (1) summary
    pfam01702
    Location:42 → 422
    TGT; Queuine tRNA-ribosyltransferase

  2. XM_039082070.2 → XP_038937998.1  queuine tRNA-ribosyltransferase catalytic subunit 1 isoform X2

    Conserved Domains (1) summary
    pfam01702
    Location:1 → 286
    TGT; Queuine tRNA-ribosyltransferase

RNA

  1. XR_005487914.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4QR99.1 GenPept UniProtKB/Swiss-Prot:Q4QR99

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools