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lima1a LIM domain and actin binding 1a [ Danio rerio (zebrafish) ]

Gene ID: 64000, updated on 9-Dec-2024

Summary

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Official Symbol
lima1aprovided by ZNC
Official Full Name
LIM domain and actin binding 1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-001120-1
See related
Ensembl:ENSDARG00000101441 AllianceGenome:ZFIN:ZDB-GENE-001120-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
eplin; lima1; cb1006; wu:fd15g06; wu:fd20b10
Summary
Predicted to enable actin filament binding activity. Predicted to be involved in actin filament bundle assembly. Predicted to be active in actin cytoskeleton and plasma membrane. Is expressed in several structures, including blood vessel; hindbrain neural plate; midbrain neural keel; nervous system; and periderm. Orthologous to human LIMA1 (LIM domain and actin binding 1). [provided by Alliance of Genome Resources, Dec 2024]
Annotation information
Annotation category: partial on reference assembly
Orthologs
all
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Genomic context

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See lima1a in Genome Data Viewer
Location:
chromosome: 23
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (36450916..36488629)
105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (36354198..36365453)

Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene cysteine sulfinic acid decarboxylase Neighboring gene zgc:174906 Neighboring gene U4 spliceosomal RNA Neighboring gene SPRY domain containing 3 Neighboring gene insulin-like growth factor binding protein 6b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Generation of a conditional lima1a allele in zebrafish using the FLEx switch technology. Jungke P, et al. Genesis, 2016 Jan. PMID 26572123
  2. Characterization of mouse epithelial protein lost in neoplasm (EPLIN) and comparison of mammalian and zebrafish EPLIN. Maul RS, et al. Gene, 2001 Jan 10. PMID 11179679
  3. Analysis of her1 and her7 mutants reveals a spatio temporal separation of the somite clock module. Choorapoikayil S, et al. PLoS One, 2012. PMID 22723933, Free PMC Article
  4. Molecular description of eye defects in the zebrafish Pax6b mutant, sunrise, reveals a Pax6b-dependent genetic network in the developing anterior chamber. Takamiya M, et al. PLoS One, 2015. PMID 25692557, Free PMC Article
  5. Gene-expression analysis of hair cell regeneration in the zebrafish lateral line. Jiang L, et al. Proc Natl Acad Sci U S A, 2014 Apr 8. PMID 24706903, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actin filament bundle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
LIM domain and actin-binding protein 1a
Names
LIM domain and actin binding 1
cytoskeleton-associated LIM domain protein
epithelial protein lost in neoplasm

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131664.1 → NP_571739.1  LIM domain and actin-binding protein 1a

    See identical proteins and their annotated locations for NP_571739.1

    Status: PROVISIONAL

    Source sequence(s)
    AF307846
    UniProtKB/TrEMBL
    Q9DEY8
    Related
    ENSDARP00000132530.2, ENSDART00000172441.2
    Conserved Domains (1) summary
    cd09485
    Location:286 → 338
    LIM_Eplin_alpha_beta; The Lim domain of Epithelial Protein Lost in Neoplasm (Eplin)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007134.7 Reference GRCz11 Primary Assembly

    Range
    36450916..36488629
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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