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Hs3st4 heparan sulfate (glucosamine) 3-O-sulfotransferase 4 [ Mus musculus (house mouse) ]

Gene ID: 628779, updated on 27-Nov-2024

Summary

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Official Symbol
Hs3st4provided by MGI
Official Full Name
heparan sulfate (glucosamine) 3-O-sulfotransferase 4provided by MGI
Primary source
MGI:MGI:1333792
See related
Ensembl:ENSMUSG00000078591 AllianceGenome:MGI:1333792
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm6915
Summary
Predicted to enable [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity. Involved in heparan sulfate proteoglycan biosynthetic process. Is expressed in ear; integumental system; and nervous system. Orthologous to human HS3ST4 (heparan sulfate-glucosamine 3-sulfotransferase 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in cortex adult (RPKM 5.4), CNS E18 (RPKM 4.8) and 5 other tissues See more
Orthologs
human all
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Genomic context

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See Hs3st4 in Genome Data Viewer
Location:
7 F3; 7 67.56 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (123581586..123998212)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (123982366..124398989)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30335 Neighboring gene predicted gene, 23788 Neighboring gene predicted gene, 26974 Neighboring gene VISTA enhancer mm687 Neighboring gene STARR-seq mESC enhancer starr_20101 Neighboring gene RIKEN cDNA 4930551E15 gene Neighboring gene predicted gene, 25759 Neighboring gene STARR-seq mESC enhancer starr_20103 Neighboring gene STARR-seq mESC enhancer starr_20104 Neighboring gene STARR-seq mESC enhancer starr_20107 Neighboring gene predicted gene, 23168 Neighboring gene predicted gene, 57516

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Determining heparan sulfate structure in the vicinity of specific sulfotransferase recognition sites by mass spectrometry. Wu ZL, et al. J Biol Chem, 2004 Jan 16. PMID 14602711
  2. A mutant-cell library for systematic analysis of heparan sulfate structure-function relationships. Qiu H, et al. Nat Methods, 2018 Nov. PMID 30377379, Free PMC Article
  3. Developmental and regional expression of heparan sulfate sulfotransferase genes in the mouse brain. Yabe T, et al. Glycobiology, 2005 Oct. PMID 15944372
  4. Chromatin remodeler Arid1a regulates subplate neuron identity and wiring of cortical connectivity. Doyle DZ, et al. Proc Natl Acad Sci U S A, 2021 May 25. PMID 34011608, Free PMC Article
  5. Multiple isoforms of heparan sulfate D-glucosaminyl 3-O-sulfotransferase. Isolation, characterization, and expression of human cdnas and identification of distinct genomic loci. Shworak NW, et al. J Biol Chem, 1999 Feb 19. PMID 9988767

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
Process Evidence Code Pubs
involved_in heparan sulfate proteoglycan biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
heparan sulfate glucosamine 3-O-sulfotransferase 4
NP_001239001.1
XP_006508167.1
XP_030098720.1
XP_030098722.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252072.2 → NP_001239001.1  heparan sulfate glucosamine 3-O-sulfotransferase 4

    Status: VALIDATED

    Source sequence(s)
    AC126278, AC151718, BQ177219, CJ154897
    Consensus CDS
    CCDS57584.1
    UniProtKB/TrEMBL
    D3YVV6
    Related
    ENSMUSP00000102045.2, ENSMUST00000106437.2
    Conserved Domains (1) summary
    pfam00685
    Location:190 → 427
    Sulfotransfer_1; Sulfotransferase domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    123581586..123998212
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242860.2 → XP_030098720.1  heparan sulfate glucosamine 3-O-sulfotransferase 4 isoform X1

    Conserved Domains (1) summary
    cl21551
    Location:190 → 238
    Sulfotransfer_3; Sulfotransferase family

  2. XM_006508104.5 → XP_006508167.1  heparan sulfate glucosamine 3-O-sulfotransferase 4 isoform X2

    Conserved Domains (1) summary
    pfam00685
    Location:32 → 204
    Sulfotransfer_1; Sulfotransferase domain

  3. XM_030242862.1 → XP_030098722.1  heparan sulfate glucosamine 3-O-sulfotransferase 4 isoform X3

    Conserved Domains (1) summary
    pfam00685
    Location:22 → 194
    Sulfotransfer_1; Sulfotransferase domain

RNA

  1. XR_003946536.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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