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Insyn2a inhibitory synaptic factor 2A [ Mus musculus (house mouse) ]

Gene ID: 627214, updated on 27-Nov-2024

Summary

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Official Symbol
Insyn2aprovided by MGI
Official Full Name
inhibitory synaptic factor 2Aprovided by MGI
Primary source
MGI:MGI:3605068
See related
Ensembl:ENSMUSG00000073805 AllianceGenome:MGI:3605068
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
InSyn2; Fam196a; B830028B13Rik
Summary
Involved in inhibitory postsynaptic potential. Located in postsynaptic density. Is active in GABA-ergic synapse and postsynaptic specialization. Orthologous to human INSYN2A (inhibitory synaptic factor 2A). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in frontal lobe adult (RPKM 1.9), CNS E18 (RPKM 1.8) and 12 other tissues See more
Orthologs
human all
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Genomic context

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See Insyn2a in Genome Data Viewer
Location:
7 F3; 7 80.86 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (134483637..134540159, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (134881908..134938430, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene DNA segment, Chr 7, ERATO Doi 443, expressed Neighboring gene STARR-seq mESC enhancer starr_20343 Neighboring gene predicted gene, 35970 Neighboring gene STARR-seq mESC enhancer starr_20344 Neighboring gene STARR-seq mESC enhancer starr_20345 Neighboring gene STARR-seq mESC enhancer starr_20346 Neighboring gene methionine aminopeptidase 2 pseudogene Neighboring gene dedicator of cytokinesis 1 Neighboring gene STARR-seq mESC enhancer starr_20355 Neighboring gene STARR-seq mESC enhancer starr_20356 Neighboring gene VISTA enhancer mm1401 Neighboring gene RIKEN cDNA 1700120G07 gene Neighboring gene STARR-seq mESC enhancer starr_20359 Neighboring gene predicted gene, 24581

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of an elaborate complex mediating postsynaptic inhibition. Uezu A, et al. Science, 2016 Sep 9. PMID 27609886, Free PMC Article
  2. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

General gene information

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Homology

Clone Names

  • MGC189982, MGC189985

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in chemical synaptic transmission, postsynaptic IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in chemical synaptic transmission, postsynaptic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in inhibitory postsynaptic potential IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in inhibitory postsynaptic potential IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in GABA-ergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in GABA-ergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic specialization IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic specialization IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
inhibitory synaptic factor 2A
Names
family with sequence similarity 196, member A
protein FAM196A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001143802.1 → NP_001137274.1  inhibitory synaptic factor 2A

    Status: VALIDATED

    Source sequence(s)
    AC100208, AC127574
    Consensus CDS
    CCDS52419.1
    UniProtKB/Swiss-Prot
    B2RY32, Q3USH1
    UniProtKB/TrEMBL
    E9PZW7
    Related
    ENSMUSP00000129222.2, ENSMUST00000171394.3
    Conserved Domains (1) summary
    pfam15265
    Location:1 → 470
    FAM196; FAM196 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    134483637..134540159 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508103.5 → XP_006508166.1  inhibitory synaptic factor 2A isoform X2

    UniProtKB/Swiss-Prot
    B2RY32, Q3USH1
    Conserved Domains (1) summary
    pfam15265
    Location:19 → 464
    FAM196; FAM196 family

  2. XM_017322443.3 → XP_017177932.1  inhibitory synaptic factor 2A isoform X1

    UniProtKB/Swiss-Prot
    B2RY32, Q3USH1
    Conserved Domains (1) summary
    pfam15265
    Location:19 → 488
    FAM196; FAM196 family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3USH1.1 GenPept UniProtKB/Swiss-Prot:Q3USH1

Gene LinkOut

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