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Lipt1 lipoyltransferase 1 [ Mus musculus (house mouse) ]

Gene ID: 623661, updated on 27-Nov-2024

Summary

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Official Symbol
Lipt1provided by MGI
Official Full Name
lipoyltransferase 1provided by MGI
Primary source
MGI:MGI:3645211
See related
Ensembl:ENSMUSG00000037216 AllianceGenome:MGI:3645211
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EG623661
Summary
Predicted to enable lipoyltransferase activity. Predicted to be involved in protein lipoylation. Located in mitochondrion. Is expressed in embryo. Orthologous to human LIPT1 (lipoyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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See Lipt1 in Genome Data Viewer
Location:
1 B; 1 16.13 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (37910819..37915309)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (37871738..37876228)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene capping protein inhibiting regulator of actin like Neighboring gene predicted gene, 39628 Neighboring gene testis specific 10 Neighboring gene STARR-seq mESC enhancer starr_00684 Neighboring gene STARR-positive B cell enhancer mm9_chr1:37921599-37921900 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:37922129-37922238 Neighboring gene MIT, microtubule interacting and transport, domain containing 1 Neighboring gene mitochondrial ribosomal protein L30 Neighboring gene lysozyme G-like 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mitochondrial fatty acid synthesis coordinates oxidative metabolism in mammalian mitochondria. Nowinski SM, et al. Elife, 2020 Aug 17. PMID 32804083, Free PMC Article
  2. Protein moonlighting elucidates the essential human pathway catalyzing lipoic acid assembly on its cognate enzymes. Cao X, et al. Proc Natl Acad Sci U S A, 2018 Jul 24. PMID 29987032, Free PMC Article
  3. Compromised mitochondrial fatty acid synthesis in transgenic mice results in defective protein lipoylation and energy disequilibrium. Smith S, et al. PLoS One, 2012. PMID 23077570, Free PMC Article
  4. Functional Assessment of Lipoyltransferase-1 Deficiency in Cells, Mice, and Humans. Ni M, et al. Cell Rep, 2019 Apr 30. PMID 31042466, Free PMC Article
  5. Compartmentalized metabolism supports midgestation mammalian development. Solmonson A, et al. Nature, 2022 Apr. PMID 35388219, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC28431

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N-acyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables lipoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lipoyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in protein lipoylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
lipoyl amidotransferase LIPT1, mitochondrial
Names
lipoate biosynthesis protein
lipoate-protein ligase
lipoyl ligase
lipoyltransferase 1, mitochondrial
NP_001033007.2
NP_001363958.1
NP_001363959.1
NP_001363960.1
NP_001363961.1
NP_001363962.1
NP_001363963.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037918.5 → NP_001033007.2  lipoyl amidotransferase LIPT1, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001033007.2

    Status: VALIDATED

    Source sequence(s)
    AC119189
    Consensus CDS
    CCDS14895.1
    UniProtKB/Swiss-Prot
    Q8VCM4
    UniProtKB/TrEMBL
    Q8C894
    Related
    ENSMUSP00000038739.4, ENSMUST00000041621.5
    Conserved Domains (1) summary
    cd16443
    Location:33 → 235
    LplA; lipoate-protein ligase

  2. NM_001377029.2 → NP_001363958.1  lipoyl amidotransferase LIPT1, mitochondrial precursor

    Status: VALIDATED

    Source sequence(s)
    AC119189
    UniProtKB/Swiss-Prot
    Q8VCM4
    UniProtKB/TrEMBL
    Q8C894
    Conserved Domains (1) summary
    cd16443
    Location:33 → 235
    LplA; lipoate-protein ligase

  3. NM_001377030.2 → NP_001363959.1  lipoyl amidotransferase LIPT1, mitochondrial precursor

    Status: VALIDATED

    Source sequence(s)
    AC119189
    UniProtKB/Swiss-Prot
    Q8VCM4
    UniProtKB/TrEMBL
    Q8C894
    Conserved Domains (1) summary
    cd16443
    Location:33 → 235
    LplA; lipoate-protein ligase

  4. NM_001377031.2 → NP_001363960.1  lipoyl amidotransferase LIPT1, mitochondrial precursor

    Status: VALIDATED

    Source sequence(s)
    AC119189
    UniProtKB/Swiss-Prot
    Q8VCM4
    UniProtKB/TrEMBL
    Q8C894
    Conserved Domains (1) summary
    cd16443
    Location:33 → 235
    LplA; lipoate-protein ligase

  5. NM_001377032.2 → NP_001363961.1  lipoyl amidotransferase LIPT1, mitochondrial precursor

    Status: VALIDATED

    Source sequence(s)
    AC119189
    UniProtKB/Swiss-Prot
    Q8VCM4
    UniProtKB/TrEMBL
    Q8C894
    Conserved Domains (1) summary
    cd16443
    Location:33 → 235
    LplA; lipoate-protein ligase

  6. NM_001377033.2 → NP_001363962.1  lipoyl amidotransferase LIPT1, mitochondrial precursor

    Status: VALIDATED

    Source sequence(s)
    AC119189
    UniProtKB/Swiss-Prot
    Q8VCM4
    UniProtKB/TrEMBL
    Q8C894
    Conserved Domains (1) summary
    cd16443
    Location:33 → 235
    LplA; lipoate-protein ligase

  7. NM_001377034.2 → NP_001363963.1  lipoyl amidotransferase LIPT1, mitochondrial precursor

    Status: VALIDATED

    Source sequence(s)
    AC119189
    UniProtKB/Swiss-Prot
    Q8VCM4
    UniProtKB/TrEMBL
    Q8C894
    Conserved Domains (1) summary
    cd16443
    Location:33 → 235
    LplA; lipoate-protein ligase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    37910819..37915309
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VCM4.1 GenPept UniProtKB/Swiss-Prot:Q8VCM4

Gene LinkOut

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