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Arhgef26 Rho guanine nucleotide exchange factor 26 [ Mus musculus (house mouse) ]

Gene ID: 622434, updated on 27-Nov-2024

Summary

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Official Symbol
Arhgef26provided by MGI
Official Full Name
Rho guanine nucleotide exchange factor 26provided by MGI
Primary source
MGI:MGI:1918053
See related
Ensembl:ENSMUSG00000036885 AllianceGenome:MGI:1918053
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SGEF; 4631416L12Rik; 8430436L14Rik
Summary
Acts upstream of or within endothelial cell morphogenesis and ruffle assembly. Is expressed in pons ventricular layer. Orthologous to human ARHGEF26 (Rho guanine nucleotide exchange factor 26). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in lung adult (RPKM 12.9), cerebellum adult (RPKM 6.2) and 21 other tissues See more
Orthologs
human all
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Genomic context

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See Arhgef26 in Genome Data Viewer
Location:
3 E1; 3 29.97 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (62244946..62369642)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (62338777..62462221)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene heat shock protein 1 (chaperonin) pseudogene 16 Neighboring gene STARR-seq mESC enhancer starr_07808 Neighboring gene STARR-seq mESC enhancer starr_07809 Neighboring gene STARR-seq mESC enhancer starr_07810 Neighboring gene STARR-seq mESC enhancer starr_07811 Neighboring gene STARR-seq mESC enhancer starr_07812 Neighboring gene predicted gene, 57711 Neighboring gene predicted gene, 33923 Neighboring gene STARR-seq mESC enhancer starr_07813 Neighboring gene STARR-seq mESC enhancer starr_07814 Neighboring gene DEAH-box helicase 36 Neighboring gene STARR-seq mESC enhancer starr_07815 Neighboring gene STARR-seq mESC enhancer starr_07816 Neighboring gene G protein-coupled receptor 149 Neighboring gene STARR-seq mESC enhancer starr_07817

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Endothelial ARHGEF26 is an angiogenic factor promoting VEGF signalling. Zhu QM, et al. Cardiovasc Res, 2022 Oct 21. PMID 34849650, Free PMC Article
  2. The guanine-nucleotide exchange factor SGEF plays a crucial role in the formation of atherosclerosis. Samson T, et al. PLoS One, 2013. PMID 23372835, Free PMC Article
  3. A collection of cDNAs enriched in upper cortical layers of the embryonic mouse brain. García-Frigola C, et al. Brain Res Mol Brain Res, 2004 Mar 30. PMID 15010206
  4. Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders. Li J, et al. Nat Neurosci, 2017 Aug. PMID 28671696, Free PMC Article
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The guanine-nucleotide exchange factor SGEF plays a crucial role in the formation of atherosclerosis.
    Title: The guanine-nucleotide exchange factor SGEF plays a crucial role in the formation of atherosclerosis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within endothelial cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within ruffle assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
rho guanine nucleotide exchange factor 26
Names
Rho guanine nucleotide exchange factor (GEF) 26
Src homology 3 domain-containing guanine nucleotide exchange factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081295.1 → NP_001074764.1  rho guanine nucleotide exchange factor 26

    See identical proteins and their annotated locations for NP_001074764.1

    Status: VALIDATED

    Source sequence(s)
    AC114424, AC122883
    Consensus CDS
    CCDS38443.1
    UniProtKB/TrEMBL
    D3YYY8
    Related
    ENSMUSP00000078281.7, ENSMUST00000079300.13
    Conserved Domains (3) summary
    cd11938
    Location:791 → 845
    SH3_ARHGEF16_26; Src homology 3 domain of the Rho guanine nucleotide exchange factors ARHGEF16 and ARHGEF26
    cd01221
    Location:641 → 779
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain
    pfam00621
    Location:441 → 620
    RhoGEF; RhoGEF domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    62244946..62369642
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163208.1 → XP_036019101.1  rho guanine nucleotide exchange factor 26 isoform X1

    Conserved Domains (2) summary
    PHA03247
    Location:18 → 239
    PHA03247; large tegument protein UL36; Provisional
    cl02571
    Location:441 → 493
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
Nucleotide Protein Strain
Heading Accession and Version

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