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Nrbp1 nuclear receptor binding protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 619579, updated on 27-Nov-2024

Summary

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Official Symbol
Nrbp1provided by RGD
Official Full Name
nuclear receptor binding protein 1provided by RGD
Primary source
RGD:1589575
See related
EnsemblRapid:ENSRNOG00000050570 AllianceGenome:RGD:1589575
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Nrbp
Summary
Predicted to enable protein homodimerization activity. Predicted to be involved in several processes, including endoplasmic reticulum to Golgi vesicle-mediated transport; epithelial cell proliferation; and in utero embryonic development. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in cytoplasm and endomembrane system. Orthologous to human NRBP1 (nuclear receptor binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 230.4), Muscle (RPKM 228.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nrbp1 in Genome Data Viewer
Location:
6q14
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (30842606..30853177, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (25122635..25133209, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (26486823..26497396, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene fibronectin type III domain containing 4 Neighboring gene intraflagellar transport 172 Neighboring gene keratinocyte associated protein 3 Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent, 1G Neighboring gene zinc finger protein 513

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Interaction of the small GTPase Rac3 with NRBP, a protein with a kinase-homology domain. De Langhe S, et al. Int J Mol Med, 2002 May. PMID 11956649
  2. MADM, a novel adaptor protein that mediates phosphorylation of the 14-3-3 binding site of myeloid leukemia factor 1. Lim R, et al. J Biol Chem, 2002 Oct 25. PMID 12176995
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
NOT enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
NOT enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
NOT enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
  
involved_in epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in in utero embryonic development ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endomembrane system ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
nuclear receptor-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034997.1 → NP_001030169.1  nuclear receptor-binding protein

    See identical proteins and their annotated locations for NP_001030169.1

    Status: PROVISIONAL

    Source sequence(s)
    BC104694
    UniProtKB/TrEMBL
    M0RCC7, Q3SWT7
    Related
    ENSRNOP00000083137.1, ENSRNOT00000108698.2
    Conserved Domains (1) summary
    cd14034
    Location:60 → 334
    PK_NRBP1; Pseudokinase domain of Nuclear Receptor Binding Protein 1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    30842606..30853177 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017594340.3 → XP_017449829.1  nuclear receptor-binding protein isoform X1

    UniProtKB/TrEMBL
    A0A8I6GDA0, M0RCC7
    Related
    ENSRNOP00000085375.1, ENSRNOT00000109359.2
    Conserved Domains (1) summary
    cd14034
    Location:60 → 342
    PK_NRBP1; Pseudokinase domain of Nuclear Receptor Binding Protein 1
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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