U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Jam2 junctional adhesion molecule 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 619374, updated on 27-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Jam2provided by RGD
Official Full Name
junctional adhesion molecule 2provided by RGD
Primary source
RGD:1561692
See related
EnsemblRapid:ENSRNOG00000042848 AllianceGenome:RGD:1561692
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable integrin binding activity. Predicted to be involved in several processes, including hematopoietic stem cell migration to bone marrow; leukocyte tethering or rolling; and negative regulation of myelination. Predicted to act upstream of or within negative regulation of cell adhesion. Predicted to be located in cell-cell contact zone and somatodendritic compartment. Predicted to be part of protein complex involved in cell adhesion. Predicted to be active in cell surface; plasma membrane; and tight junction. Human ortholog(s) of this gene implicated in basal ganglia calcification. Orthologous to human JAM2 (junctional adhesion molecule 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 308.3), Lung (RPKM 301.2) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Jam2 in Genome Data Viewer
Location:
11q11
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (37316287..37366517)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (23830820..23880071)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (24235310..24285279)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA70 Neighboring gene mitochondrial ribosomal protein L39 Neighboring gene ATP synthase peripheral stalk subunit F6 Neighboring gene GA binding protein transcription factor subunit alpha Neighboring gene amyloid beta precursor protein Neighboring gene uncharacterized LOC134480962

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Somatodendritic Expression of JAM2 Inhibits Oligodendrocyte Myelination. Redmond SA, et al. Neuron, 2016 Aug 17. PMID 27499083, Free PMC Article
  2. Junctional adhesion molecule-2 (JAM-2) promotes lymphocyte transendothelial migration. Johnson-Léger CA, et al. Blood, 2002 Oct 1. PMID 12239159
  3. Junctional adhesion molecules (JAM)-B and -C contribute to leukocyte extravasation to the skin and mediate cutaneous inflammation. Ludwig RJ, et al. J Invest Dermatol, 2005 Nov. PMID 16297198
  4. Spermatid differentiation requires the assembly of a cell polarity complex downstream of junctional adhesion molecule-C. Gliki G, et al. Nature, 2004 Sep 16. PMID 15372036
  5. JAM2 interacts with alpha4beta1. Facilitation by JAM3. Cunningham SA, et al. J Biol Chem, 2002 Aug 2. PMID 12070135

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables integrin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular extravasation ISO
Inferred from Sequence Orthology
more info
  
involved_in hematopoietic stem cell migration to bone marrow ISO
Inferred from Sequence Orthology
more info
  
involved_in leukocyte cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in leukocyte tethering or rolling ISO
Inferred from Sequence Orthology
more info
  
involved_in lymphocyte aggregation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of myelination ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of lymphocyte migration ISO
Inferred from Sequence Orthology
more info
  
involved_in spermatid development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
NOT located_in axon ISO
Inferred from Sequence Orthology
more info
  
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in cell-cell contact zone ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of protein complex involved in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein complex involved in cell adhesion ISO
Inferred from Sequence Orthology
more info
  
located_in somatodendritic compartment ISO
Inferred from Sequence Orthology
more info
  
is_active_in tight junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in tight junction ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
junctional adhesion molecule B
Names
junction adhesion molecule 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034004.1 → NP_001029176.1  junctional adhesion molecule B precursor

    See identical proteins and their annotated locations for NP_001029176.1

    Status: PROVISIONAL

    Source sequence(s)
    BC105305
    UniProtKB/TrEMBL
    A6JL57, F1M065, Q3MHC0
    Related
    ENSRNOP00000049564.6, ENSRNOT00000046973.7
    Conserved Domains (3) summary
    cd00096
    Location:47 → 113
    Ig; Immunoglobulin domain
    smart00408
    Location:148 → 221
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:37 → 131
    IG_like; Immunoglobulin like

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    37316287..37366517
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039088608.2 → XP_038944536.1  junctional adhesion molecule B isoform X1

    UniProtKB/TrEMBL
    A6JL57
    Conserved Domains (2) summary
    cd00096
    Location:38 → 42
    Ig; Ig strand A' [structural motif]
    cl11960
    Location:36 → 132
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous