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DVL2 dishevelled segment polarity protein 2 [ Bos taurus (domestic cattle) ]

Gene ID: 614312, updated on 30-Jan-2025

Summary

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Official Symbol
DVL2provided by VGNC
Official Full Name
dishevelled segment polarity protein 2provided by VGNC
Primary source
VGNC:VGNC:28265
See related
EnsemblRapid:ENSBTAG00070016737
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See DVL2 in Genome Data Viewer
Location:
chromosome: 19
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 19 NC_037346.1 (26940116..26948321, complement)

Chromosome 19 - NC_037346.1Genomic Context describing neighboring genes Neighboring gene discs large MAGUK scaffold protein 4 Neighboring gene acyl-CoA dehydrogenase very long chain Neighboring gene microRNA mir-324 Neighboring gene PHD finger protein 23 Neighboring gene GABA type A receptor-associated protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037346.1 Chromosome 19 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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Related articles in PubMed

  1. Dvl2 silencing in postdevelopmental cells results in aberrant cell membrane activity and actin disorganization. Wechezak AR, et al. J Cell Physiol, 2005 Mar. PMID 15593083
  2. A second generation radiation hybrid map to aid the assembly of the bovine genome sequence. Jann OC, et al. BMC Genomics, 2006 Nov 6. PMID 17087818, Free PMC Article
  3. Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle. Smith TP, et al. Genome Res, 2001 Apr. PMID 11282978, Free PMC Article
  4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables frizzled binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
segment polarity protein dishevelled homolog DVL-2
Names
dishevelled, dsh homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191382.1 → NP_001178311.1  segment polarity protein dishevelled homolog DVL-2

    See identical proteins and their annotated locations for NP_001178311.1

    Status: VALIDATED

    Source sequence(s)
    AW437452, BE722341, CO896917, DV927997, EE334918, EE911306, NKLS02000019
    UniProtKB/TrEMBL
    E1BK34
    Conserved Domains (5) summary
    smart00021
    Location:13 → 93
    DAX; Domain present in Dishevelled and axin
    cd00992
    Location:261 → 348
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04438
    Location:420 → 503
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    pfam02377
    Location:123 → 259
    Dishevelled; Dishevelled specific domain
    pfam12316
    Location:520 → 730
    Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037346.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    26940116..26948321 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024980406.2 → XP_024836174.1  segment polarity protein dishevelled homolog DVL-2 isoform X4

    UniProtKB/TrEMBL
    E1BK34
    Related
    ENSBTAP00070022025.1, ENSBTAT00070037534.1
    Conserved Domains (5) summary
    smart00021
    Location:13 → 93
    DAX; Domain present in Dishevelled and axin
    cd00992
    Location:261 → 348
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04438
    Location:420 → 503
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    pfam02377
    Location:123 → 259
    Dishevelled; Dishevelled specific domain
    pfam12316
    Location:511 → 722
    Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

  2. XM_059878222.1 → XP_059734205.1  segment polarity protein dishevelled homolog DVL-2 isoform X3

    UniProtKB/TrEMBL
    E1BK34

  3. XM_005220246.5 → XP_005220303.1  segment polarity protein dishevelled homolog DVL-2 isoform X2

    See identical proteins and their annotated locations for XP_005220303.1

    UniProtKB/TrEMBL
    E1BK34
    Conserved Domains (5) summary
    smart00021
    Location:13 → 93
    DAX; Domain present in Dishevelled and axin
    cd00992
    Location:265 → 352
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04438
    Location:424 → 507
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    pfam02377
    Location:123 → 263
    Dishevelled; Dishevelled specific domain
    pfam12316
    Location:515 → 726
    Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

  4. XM_010815942.4 → XP_010814244.1  segment polarity protein dishevelled homolog DVL-2 isoform X1

    UniProtKB/TrEMBL
    E1BK34
    Conserved Domains (5) summary
    smart00021
    Location:13 → 93
    DAX; Domain present in Dishevelled and axin
    cd00992
    Location:266 → 353
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04438
    Location:425 → 508
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    pfam02377
    Location:123 → 264
    Dishevelled; Dishevelled specific domain
    pfam12316
    Location:516 → 727
    Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal
Nucleotide Protein Strain
Heading Accession and Version

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