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pygo2 pygopus homolog 2 (Drosophila) [ Danio rerio (zebrafish) ]

Gene ID: 613247, updated on 4-Jan-2025

Summary

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Official Symbol
pygo2provided by ZNC
Official Full Name
pygopus homolog 2 (Drosophila)provided by ZNC
Primary source
ZFIN:ZDB-GENE-050809-108
See related
Ensembl:ENSDARG00000036772 AllianceGenome:ZFIN:ZDB-GENE-050809-108
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wu:fc46c10; wu:fi37d10; wu:fj66f08; wu:fy30b05; zgc:111854
Summary
Predicted to enable metal ion binding activity. Acts upstream of or within embryonic viscerocranium morphogenesis and regulation of canonical Wnt signaling pathway. Predicted to be located in nucleus. Orthologous to human PYGO2 (pygopus family PHD finger 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See pygo2 in Genome Data Viewer
Location:
chromosome: 19
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (7627064..7633062)
105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (7708100..7714137)

Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene S100 calcium binding protein U Neighboring gene S100 calcium binding protein S Neighboring gene cingulin b Neighboring gene upregulator of cell proliferation

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Mutations in Bcl9 and Pygo genes cause congenital heart defects by tissue-specific perturbation of Wnt/β-catenin signaling. Cantù C, et al. Genes Dev, 2018 Nov 1. PMID 30366904, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC111854, MGC173911

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within embryonic viscerocranium morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
pygopus homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033111.3 → NP_001028283.2  pygopus homolog 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    CR628394
    UniProtKB/TrEMBL
    A0A8M1N7S4, Q1L8T6
    Related
    ENSDARP00000117585.1, ENSDART00000131324.3
    Conserved Domains (1) summary
    cd15636
    Location:494 → 547
    PHD_PYGO2; PHD finger found in pygopus homolog 2 (PYGO2)

  2. NM_001365173.1 → NP_001352102.1  pygopus homolog 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    CR628394
    UniProtKB/TrEMBL
    A0A8M2B671
    Conserved Domains (2) summary
    cd15636
    Location:479 → 532
    PHD_PYGO2; PHD finger found in pygopus homolog 2 (PYGO2)
    cl25764
    Location:303 → 412
    PAT1; Topoisomerase II-associated protein PAT1

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007130.7 Reference GRCz11 Primary Assembly

    Range
    7627064..7633062
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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