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Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 60664, updated on 27-Nov-2024

Summary

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Official Symbol
Pik3r3provided by RGD
Official Full Name
phosphoinositide-3-kinase regulatory subunit 3provided by RGD
Primary source
RGD:621042
See related
EnsemblRapid:ENSRNOG00000000145 AllianceGenome:RGD:621042
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables 1-phosphatidylinositol-3-kinase regulator activity. Predicted to be involved in several processes, including cell migration involved in sprouting angiogenesis; insulin receptor signaling pathway; and positive regulation of macromolecule metabolic process. Predicted to be part of phosphatidylinositol 3-kinase complex, class IA. Biomarker of hepatocellular carcinoma. Human ortholog(s) of this gene implicated in colon adenocarcinoma. Orthologous to human PIK3R3 (phosphoinositide-3-kinase regulatory subunit 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 170.7), Lung (RPKM 127.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pik3r3 in Genome Data Viewer
Location:
5q35
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (134936790..135009303)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (129700925..129772591)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (135069972..135145633)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene tetraspanin 1 Neighboring gene PIK3R3 upstream open reading frame Neighboring gene uncharacterized LOC120103122 Neighboring gene transfer RNA proline (anticodon AGG) 7 Neighboring gene microtubule associated serine/threonine kinase 2 Neighboring gene U6 spliceosomal RNA Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of PI3K regulatory subunit p55γ as a novel inhibitor of vascular smooth muscle cell proliferation and neointimal formation. Li G, et al. Cardiovasc Res, 2015 Jan 1. PMID 25388664
  2. PIK3R3 induces epithelial-to-mesenchymal transition and promotes metastasis in colorectal cancer. Wang G, et al. Mol Cancer Ther, 2014 Jul. PMID 24837077
  3. Analysis of expression profile of gene encoding proteins of signal cascades activated by insulin-like growth factors in colorectal cancer. Nowakowska-Zajdel E, et al. Int J Immunopathol Pharmacol, 2011 Jul-Sep. PMID 21978709
  4. A novel 55-kDa regulatory subunit for phosphatidylinositol 3-kinase structurally similar to p55PIK Is generated by alternative splicing of the p85alpha gene. Inukai K, et al. J Biol Chem, 1996 Mar 8. PMID 8621382
  5. MicroRNA-365 inhibits proliferation, migration and invasion of glioma by targeting PIK3R3. Zhu Y, et al. Oncol Rep, 2017 Apr. PMID 28260020

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Western blot and mRNA analyses showed that p55gamma expression declined in balloon-injured carotid arteries.
    Title: Identification of PI3K regulatory subunit p55γ as a novel inhibitor of vascular smooth muscle cell proliferation and neointimal formation.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1-phosphatidylinositol-3-kinase regulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 1-phosphatidylinositol-3-kinase regulator activity IEA
Inferred from Electronic Annotation
more info
  
enables 1-phosphatidylinositol-3-kinase regulator activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphotyrosine residue binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphotyrosine residue binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell migration involved in sprouting angiogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in cell migration involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in insulin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of phosphatidylinositol 3-kinase complex IEA
Inferred from Electronic Annotation
more info
  
part_of phosphatidylinositol 3-kinase complex ISO
Inferred from Sequence Orthology
more info
  
part_of phosphatidylinositol 3-kinase complex, class IA IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
phosphatidylinositol 3-kinase regulatory subunit gamma
Names
PI3-kinase p85 subunit gamma
PI3-kinase regulatory subunit gamma
PI3-kinase subunit p55-gamma
PI3K regulatory subunit gamma
p55PIK
phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55)
phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma
phosphatidylinositol 3-kinase p55 subunit
phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
ptdIns-3-kinase p85-gamma
ptdIns-3-kinase regulatory subunit gamma
ptdIns-3-kinase regulatory subunit p55-gamma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001429916.1 → NP_001416845.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A6JZ71, G3V605

  2. NM_001429917.1 → NP_001416846.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A6JZ71, G3V605

  3. NM_001429918.1 → NP_001416847.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A6JZ71, G3V605

  4. NM_001429919.1 → NP_001416848.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005

  5. NM_001429920.1 → NP_001416849.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005

  6. NM_001429921.1 → NP_001416850.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005

  7. NM_001429922.1 → NP_001416851.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005

  8. NM_001429923.1 → NP_001416852.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005

  9. NM_022213.3 → NP_071549.2  phosphatidylinositol 3-kinase regulatory subunit gamma isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    Q63789
    UniProtKB/TrEMBL
    A6JZ71, G3V605
    Related
    ENSRNOP00000000157.2, ENSRNOT00000000157.5
    Conserved Domains (3) summary
    cd09930
    Location:351 → 454
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:59 → 167
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cl25402
    Location:172 → 332
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    134936790..135009303
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039110699.2 → XP_038966627.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1

    Conserved Domains (3) summary
    cd09930
    Location:351 → 454
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:59 → 167
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cl25402
    Location:172 → 332
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

  2. XM_006238714.4 → XP_006238776.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1

    Conserved Domains (3) summary
    cd09930
    Location:351 → 454
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:59 → 167
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cl25402
    Location:172 → 332
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

  3. XM_039110698.2 → XP_038966626.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1

    Conserved Domains (3) summary
    cd09930
    Location:351 → 454
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:59 → 167
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cl25402
    Location:172 → 332
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q63789.1 GenPept UniProtKB/Swiss-Prot:Q63789

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