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Arpp19 cAMP-regulated phosphoprotein 19 [ Rattus norvegicus (Norway rat) ]

Gene ID: 60336, updated on 27-Nov-2024

Summary

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Official Symbol
Arpp19provided by RGD
Official Full Name
cAMP-regulated phosphoprotein 19provided by RGD
Primary source
RGD:71054
See related
EnsemblRapid:ENSRNOG00000063103 AllianceGenome:RGD:71054
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Arpp-19
Summary
Predicted to enable several functions, including potassium channel regulator activity; protein phosphatase 2A binding activity; and protein phosphatase inhibitor activity. Involved in G protein-coupled dopamine receptor signaling pathway and positive regulation of Ras protein signal transduction. Located in cytosol; dendrite; and synapse. Orthologous to human ARPP19 (cAMP regulated phosphoprotein 19). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 502.0), Lung (RPKM 293.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Arpp19 in Genome Data Viewer
Location:
8q24
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (84660166..84683012)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (75779640..75802474)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (81949577..81972054)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene one cut homeobox 1 Neighboring gene atos homolog A Neighboring gene myosin VA Neighboring gene small nucleolar RNA U3 Neighboring gene myosin VC

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Expression of ARPP-16/19 in rat denervated skeletal muscle. Yoshikawa A, et al. J Biochem, 2003 Jul. PMID 12944371
  2. Nerve growth factor controls GAP-43 mRNA stability via the phosphoprotein ARPP-19. Irwin N, et al. Proc Natl Acad Sci U S A, 2002 Sep 17. PMID 12221279, Free PMC Article
  3. Differential expression of ARPP-16 and ARPP-19, two highly related cAMP-regulated phosphoproteins, one of which is specifically associated with dopamine-innervated brain regions. Girault JA, et al. J Neurosci, 1990 Apr. PMID 2158525, Free PMC Article
  4. ARPP-16/ARPP-19: a highly conserved family of cAMP-regulated phosphoproteins. Dulubova I, et al. J Neurochem, 2001 Apr. PMID 11279279
  5. Human alpha-endosulfine, a possible regulator of sulfonylurea-sensitive KATP channel: molecular cloning, expression and biological properties. Heron L, et al. Proc Natl Acad Sci U S A, 1998 Jul 7. PMID 9653196, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ARPP-19 is an important link between NGF signaling and post-transcriptional control of neuronal gene expression.
    Title: Nerve growth factor controls GAP-43 mRNA stability via the phosphoprotein ARPP-19.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables phosphatase inhibitor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables potassium channel regulator activity ISO
Inferred from Sequence Orthology
more info
  
enables protein phosphatase 2A binding ISO
Inferred from Sequence Orthology
more info
  
enables protein phosphatase 2A binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein phosphatase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein phosphatase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein phosphatase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein phosphatase regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled dopamine receptor signaling pathway IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in G2/M transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in G2/M transition of mitotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of Ras protein signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of gluconeogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cAMP-regulated phosphoprotein 19
Names
cyclic AMP phosphoprotein, 19 kDa
cyclic AMP phosphoprotein, 19kD

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395717.1 → NP_001382646.1  cAMP-regulated phosphoprotein 19 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    JAXUCZ010000008

  2. NM_001395718.1 → NP_001382647.1  cAMP-regulated phosphoprotein 19 isoform b

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/Swiss-Prot
    Q712U5
    UniProtKB/TrEMBL
    A0A8I6A898, A6I1B0
    Conserved Domains (1) summary
    pfam04667
    Location:28 → 103
    Endosulfine; cAMP-regulated phosphoprotein/endosulfine conserved region

  3. NM_001395719.1 → NP_001382648.1  cAMP-regulated phosphoprotein 19 isoform b

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/Swiss-Prot
    Q712U5
    UniProtKB/TrEMBL
    A0A8I6A898, A6I1B0
    Related
    ENSRNOP00000109754.1, ENSRNOT00000153864.1
    Conserved Domains (1) summary
    pfam04667
    Location:28 → 103
    Endosulfine; cAMP-regulated phosphoprotein/endosulfine conserved region

  4. NM_031660.2 → NP_113848.1  cAMP-regulated phosphoprotein 19 isoform b

    See identical proteins and their annotated locations for NP_113848.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/Swiss-Prot
    Q712U5
    UniProtKB/TrEMBL
    A0A8I6A898, A6I1B0
    Conserved Domains (1) summary
    pfam04667
    Location:28 → 103
    Endosulfine; cAMP-regulated phosphoprotein/endosulfine conserved region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    84660166..84683012
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063266060.1 → XP_063122130.1  cAMP-regulated phosphoprotein 19 isoform X3

  2. XM_063266062.1 → XP_063122132.1  cAMP-regulated phosphoprotein 19 isoform X4

  3. XM_063266059.1 → XP_063122129.1  cAMP-regulated phosphoprotein 19 isoform X2

    UniProtKB/TrEMBL
    A6I1A8

  4. XM_039082046.2 → XP_038937974.2  cAMP-regulated phosphoprotein 19 isoform X1

    Related
    ENSRNOP00000087184.3, ENSRNOT00000098678.3

  5. XM_063266061.1 → XP_063122131.1  cAMP-regulated phosphoprotein 19 isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q712U5.3 GenPept UniProtKB/Swiss-Prot:Q712U5

Gene LinkOut

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