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RGS12 regulator of G protein signaling 12 [ Homo sapiens (human) ]

Gene ID: 6002, updated on 27-Nov-2024

Summary

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Official Symbol
RGS12provided by HGNC
Official Full Name
regulator of G protein signaling 12provided by HGNC
Primary source
HGNC:HGNC:9994
See related
Ensembl:ENSG00000159788 MIM:602512; AllianceGenome:HGNC:9994
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the 'regulator of G protein signaling' (RGS) gene family. The encoded protein may function as a guanosine triphosphatase (GTPase)-activating protein as well as a transcriptional repressor. This protein may play a role in tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in skin (RPKM 3.7), brain (RPKM 3.2) and 24 other tissues See more
Orthologs
mouse all
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Genomic context

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See RGS12 in Genome Data Viewer
Location:
4p16.3
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (3285891..3439913)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (3284640..3439697)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (3287618..3441640)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21218 Neighboring gene RNA, U7 small nuclear 33 pseudogene Neighboring gene huntingtin Neighboring gene ReSE screen-validated silencer GRCh37_chr4:3137138-3137317 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15201 Neighboring gene Sharpr-MPRA regulatory region 10599 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3215178-3215678 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3215679-3216179 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:3239294-3239953 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr4:3239954-3240612 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:3248264-3248439 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:3252404-3253300 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3271939-3272476 Neighboring gene Myb/SANT DNA binding domain containing 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15202 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15203 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15204 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:3295537-3296122 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:3296907-3297102 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21219 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21220 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3306185-3306834 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3310051-3310769 Neighboring gene X antigen family member 3 pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:3319084-3319638 Neighboring gene ribosomal protein L7a pseudogene 29 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3374529-3375457 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21222 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21223 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21224 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3411075-3411982 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr4:3417810-3419009 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3422145-3422646 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3425913-3426412 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3434795-3435296 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3435297-3435796 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3436172-3437070 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3437071-3437969 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3438515-3439015 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15205 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3450782-3451585 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:3463811-3464658 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3467576-3468185 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3469405-3470012 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:3474943-3475654 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:3476364-3476557 Neighboring gene vegetative cell wall protein gp1-like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3481667-3482258 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr4:3482478-3483445 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3483446-3484412 Neighboring gene HGF activator Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr4:3486115-3487314 Neighboring gene docking protein 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Molecular cloning of regulators of G-protein signaling family members and characterization of binding specificity of RGS12 PDZ domain. Snow BE, et al. Methods Enzymol, 2002. PMID 11771424
  2. Use of representational difference analysis and cDNA arrays for transcriptional profiling of tumor tissue. Frohme M, et al. Ann N Y Acad Sci, 2000 Jun. PMID 10911908
  3. RGS12 Represses Oral Cancer via the Phosphorylation and SUMOylation of PTEN. Fu C, et al. J Dent Res, 2021 May. PMID 33198557, Free PMC Article
  4. RGS12 Drives Macrophage Activation and Osteoclastogenesis in Periodontitis. Yuan G, et al. J Dent Res, 2022 Apr. PMID 34796776, Free PMC Article
  5. RGS12 inhibits the progression and metastasis of multiple myeloma by driving M1 macrophage polarization and activation in the bone marrow microenvironment. Yuan G, et al. Cancer Commun (Lond), 2022 Jan. PMID 34931491, Free PMC Article

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Distinct and overlapping RGS14 and RGS12 actions regulate NPT2A-mediated phosphate transport.
    Title: Distinct and overlapping RGS14 and RGS12 actions regulate NPT2A-mediated phosphate transport.
  2. RGS12 represses oral squamous cell carcinoma by driving M1 polarization of tumor-associated macrophages via controlling ciliary MYCBP2/KIF2A signaling.
    Title: RGS12 represses oral squamous cell carcinoma by driving M1 polarization of tumor-associated macrophages via controlling ciliary MYCBP2/KIF2A signaling.
  3. RGS12 Drives Macrophage Activation and Osteoclastogenesis in Periodontitis.
    Title: RGS12 Drives Macrophage Activation and Osteoclastogenesis in Periodontitis.
  4. RGS12 inhibits the progression and metastasis of multiple myeloma by driving M1 macrophage polarization and activation in the bone marrow microenvironment.
    Title: RGS12 inhibits the progression and metastasis of multiple myeloma by driving M1 macrophage polarization and activation in the bone marrow microenvironment.
  5. RGS12 is a novel tumor suppressor in osteosarcoma that inhibits YAP-TEAD1-Ezrin signaling.
    Title: RGS12 is a novel tumor suppressor in osteosarcoma that inhibits YAP-TEAD1-Ezrin signaling.
  6. RGS12 Represses Oral Cancer via the Phosphorylation and SUMOylation of PTEN.
    Title: RGS12 Represses Oral Cancer via the Phosphorylation and SUMOylation of PTEN.
  7. Findings identify RGS12 as a candidate tumor-suppressor gene in AA prostate cancer, which acts by decreasing expression of AKT and MNX1, establishing a novel oncogenic axis in this disparate disease setting.
    Title: RGS12 Is a Novel Tumor-Suppressor Gene in African American Prostate Cancer That Represses AKT and MNX1 Expression.
  8. Data support the notion that the Galpha, but not Gbetagamma, arm of the Gi/o signalling is involved in TRPC4 activation and unveil new roles for RGS and RGS12 in fine-tuning TRPC4 activities.
    Title: Regulator of G-protein signalling and GoLoco proteins suppress TRPC4 channel function via acting at Gαi/o.
  9. Observational study of gene-disease association. (HuGE Navigator)
    Title: Genetic variations in regulator of G-protein signaling genes as susceptibility loci for second primary tumor/recurrence in head and neck squamous cell carcinoma.
  10. RGS12 is essential for the terminal differentiation of osteoclasts induced by RANKL.
    Title: RGS12 is essential for RANKL-evoked signaling for terminal differentiation of osteoclasts in vitro.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp761K1617, DKFZp761K1817

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity TAS
Traceable Author Statement
more info
  
enables GTPase regulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
  
involved_in negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in condensed nuclear chromosome TAS
Traceable Author Statement
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in dendrite ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nuclear matrix IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
colocalizes_with synapse ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
regulator of G-protein signaling 12
Names
regulator of G-protein signalling 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029903.2 RefSeqGene

    Range
    12132..159024
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001394154.1 → NP_001381083.1  regulator of G-protein signaling 12 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL590235, AL645949
    Consensus CDS
    CCDS3366.1
    UniProtKB/Swiss-Prot
    B1AQ30, B1AQ31, B1AQ32, B7Z764, E7EMN9, O14922, O14923, O14924, O43510, O75338, Q147X0, Q8WX95
    Related
    ENSP00000338509.4, ENST00000336727.8
    Conserved Domains (9) summary
    cd08742
    Location:716 → 830
    RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein
    smart00390
    Location:1188 → 1209
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    cd00992
    Location:20 → 96
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13162
    Location:228 → 359
    PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold
    cd17136
    Location:962 → 1031
    RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)
    pfam16611
    Location:1106 → 1180
    RGS12_us2; Unstructured region between RBD and GoLoco
    pfam16612
    Location:1239 → 1376
    RGS12_usC; C-terminal unstructured region of RGS12
    pfam16613
    Location:836 → 949
    RGS12_us1; Unstructured region of RGS12
    cl28922
    Location:1032 → 1104
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  2. NM_001394155.1 → NP_001381084.1  regulator of G-protein signaling 12 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL590235, AL645949
    Consensus CDS
    CCDS3366.1
    UniProtKB/Swiss-Prot
    B1AQ30, B1AQ31, B1AQ32, B7Z764, E7EMN9, O14922, O14923, O14924, O43510, O75338, Q147X0, Q8WX95
    Conserved Domains (9) summary
    cd08742
    Location:716 → 830
    RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein
    smart00390
    Location:1188 → 1209
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    cd00992
    Location:20 → 96
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13162
    Location:228 → 359
    PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold
    cd17136
    Location:962 → 1031
    RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)
    pfam16611
    Location:1106 → 1180
    RGS12_us2; Unstructured region between RBD and GoLoco
    pfam16612
    Location:1239 → 1376
    RGS12_usC; C-terminal unstructured region of RGS12
    pfam16613
    Location:836 → 949
    RGS12_us1; Unstructured region of RGS12
    cl28922
    Location:1032 → 1104
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  3. NM_001394156.1 → NP_001381085.1  regulator of G-protein signaling 12 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL590235, AL645949
    Consensus CDS
    CCDS3367.1
    Related
    ENSP00000372238.3, ENST00000382788.7
    Conserved Domains (9) summary
    cd08742
    Location:716 → 830
    RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein
    smart00390
    Location:1188 → 1209
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    cd00992
    Location:20 → 96
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13162
    Location:228 → 359
    PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold
    cd17136
    Location:962 → 1031
    RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)
    pfam16611
    Location:1106 → 1180
    RGS12_us2; Unstructured region between RBD and GoLoco
    pfam16612
    Location:1239 → 1376
    RGS12_usC; C-terminal unstructured region of RGS12
    pfam16613
    Location:836 → 949
    RGS12_us1; Unstructured region of RGS12
    cl28922
    Location:1032 → 1104
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  4. NM_001394157.1 → NP_001381086.1  regulator of G-protein signaling 12 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL590235, AL645949
    UniProtKB/TrEMBL
    Q56A82
    Conserved Domains (5) summary
    cd08742
    Location:716 → 830
    RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein
    cd00992
    Location:20 → 96
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13162
    Location:228 → 359
    PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold
    cd17136
    Location:962 → 1031
    RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)
    cl28922
    Location:1032 → 1104
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  5. NM_001394158.1 → NP_001381087.1  regulator of G-protein signaling 12 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL590235, AL645949
    UniProtKB/TrEMBL
    Q56A82
    Conserved Domains (7) summary
    cd08742
    Location:716 → 830
    RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein
    cd00992
    Location:20 → 96
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13162
    Location:228 → 359
    PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold
    cd17136
    Location:962 → 1031
    RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)
    pfam16611
    Location:1106 → 1137
    RGS12_us2; Unstructured region between RBD and GoLoco
    pfam16613
    Location:836 → 949
    RGS12_us1; Unstructured region of RGS12
    cl28922
    Location:1032 → 1104
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  6. NM_001394159.1 → NP_001381088.1  regulator of G-protein signaling 12 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL645949
    Conserved Domains (4) summary
    PHA03247
    Location:452 → 814
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:20 → 96
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13162
    Location:228 → 359
    PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold
    cd21577
    Location:738 → 824
    KLF3_N; N-terminal domain of Kruppel-like factor 3

  7. NM_001394161.1 → NP_001381090.1  regulator of G-protein signaling 12 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL590235, AL645949
    UniProtKB/TrEMBL
    Q506M0
    Conserved Domains (7) summary
    smart00390
    Location:387 → 408
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    cd17136
    Location:161 → 230
    RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)
    pfam16611
    Location:305 → 379
    RGS12_us2; Unstructured region between RBD and GoLoco
    pfam16612
    Location:438 → 575
    RGS12_usC; C-terminal unstructured region of RGS12
    pfam16613
    Location:35 → 148
    RGS12_us1; Unstructured region of RGS12
    cl02565
    Location:1 → 29
    RGS; Regulator of G protein signaling (RGS) domain superfamily
    cl28922
    Location:231 → 303
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  8. NM_001394162.1 → NP_001381091.1  regulator of G-protein signaling 12 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL590235, AL645949
    UniProtKB/TrEMBL
    Q506M0
    Conserved Domains (7) summary
    smart00390
    Location:387 → 408
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    cd17136
    Location:161 → 230
    RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)
    pfam16611
    Location:305 → 379
    RGS12_us2; Unstructured region between RBD and GoLoco
    pfam16612
    Location:438 → 575
    RGS12_usC; C-terminal unstructured region of RGS12
    pfam16613
    Location:35 → 148
    RGS12_us1; Unstructured region of RGS12
    cl02565
    Location:1 → 29
    RGS; Regulator of G protein signaling (RGS) domain superfamily
    cl28922
    Location:231 → 303
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  9. NM_001394163.1 → NP_001381092.1  regulator of G-protein signaling 12 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL590235, AL645949
    UniProtKB/TrEMBL
    Q506M0
    Conserved Domains (7) summary
    smart00390
    Location:387 → 408
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    cd17136
    Location:161 → 230
    RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)
    pfam16611
    Location:305 → 379
    RGS12_us2; Unstructured region between RBD and GoLoco
    pfam16612
    Location:438 → 575
    RGS12_usC; C-terminal unstructured region of RGS12
    pfam16613
    Location:35 → 148
    RGS12_us1; Unstructured region of RGS12
    cl02565
    Location:1 → 29
    RGS; Regulator of G protein signaling (RGS) domain superfamily
    cl28922
    Location:231 → 303
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  10. NM_002926.5 → NP_002917.1  regulator of G-protein signaling 12 isoform 2

    See identical proteins and their annotated locations for NP_002917.1

    Status: REVIEWED

    Source sequence(s)
    AL590235, AL645949
    Consensus CDS
    CCDS3367.1
    UniProtKB/Swiss-Prot
    O14924
    Conserved Domains (9) summary
    cd08742
    Location:716 → 830
    RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein
    smart00390
    Location:1188 → 1209
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    cd00992
    Location:20 → 96
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13162
    Location:228 → 359
    PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold
    cd17136
    Location:962 → 1031
    RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)
    pfam16611
    Location:1106 → 1180
    RGS12_us2; Unstructured region between RBD and GoLoco
    pfam16612
    Location:1239 → 1376
    RGS12_usC; C-terminal unstructured region of RGS12
    pfam16613
    Location:836 → 949
    RGS12_us1; Unstructured region of RGS12
    cl28922
    Location:1032 → 1104
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  11. NM_198227.2 → NP_937870.1  regulator of G-protein signaling 12 isoform 3

    See identical proteins and their annotated locations for NP_937870.1

    Status: REVIEWED

    Source sequence(s)
    AF030109, AF030112, BM984992, CB242608
    Consensus CDS
    CCDS3368.1
    UniProtKB/TrEMBL
    Q506M0
    Related
    ENSP00000342133.4, ENST00000338806.4
    Conserved Domains (7) summary
    smart00455
    Location:387 → 456
    RBD; Raf-like Ras-binding domain
    cd01817
    Location:315 → 387
    RGS12_RBD; Ubiquitin domain of RGS12 and RGS14
    cd08742
    Location:68 → 182
    RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein
    pfam02188
    Location:540 → 561
    GoLoco; GoLoco motif
    pfam16611
    Location:458 → 528
    RGS12_us2; Unstructured region between RBD and GoLoco
    pfam16612
    Location:606 → 726
    RGS12_usC; C-terminal unstructured region of RGS12
    pfam16613
    Location:188 → 285
    RGS12_us1; Unstructured region of RGS12

  12. NM_198229.3 → NP_937872.1  regulator of G-protein signaling 12 isoform 1

    See identical proteins and their annotated locations for NP_937872.1

    Status: REVIEWED

    Source sequence(s)
    AL590235, AL645949
    Consensus CDS
    CCDS3366.1
    UniProtKB/Swiss-Prot
    B1AQ30, B1AQ31, B1AQ32, B7Z764, E7EMN9, O14922, O14923, O14924, O43510, O75338, Q147X0, Q8WX95
    Related
    ENSP00000339381.5, ENST00000344733.9
    Conserved Domains (9) summary
    cd08742
    Location:716 → 830
    RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein
    smart00390
    Location:1188 → 1209
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    cd00992
    Location:20 → 96
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13162
    Location:228 → 359
    PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold
    cd17136
    Location:962 → 1031
    RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)
    pfam16611
    Location:1106 → 1180
    RGS12_us2; Unstructured region between RBD and GoLoco
    pfam16612
    Location:1239 → 1376
    RGS12_usC; C-terminal unstructured region of RGS12
    pfam16613
    Location:836 → 949
    RGS12_us1; Unstructured region of RGS12
    cl28922
    Location:1032 → 1104
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    3285891..3439913
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011513543.3 → XP_011511845.1  regulator of G-protein signaling 12 isoform X5

    See identical proteins and their annotated locations for XP_011511845.1

    UniProtKB/TrEMBL
    Q506M0
    Conserved Domains (7) summary
    smart00390
    Location:387 → 408
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    cd17136
    Location:161 → 230
    RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)
    pfam16611
    Location:305 → 379
    RGS12_us2; Unstructured region between RBD and GoLoco
    pfam16612
    Location:438 → 575
    RGS12_usC; C-terminal unstructured region of RGS12
    pfam16613
    Location:35 → 148
    RGS12_us1; Unstructured region of RGS12
    cl02565
    Location:1 → 29
    RGS; Regulator of G protein signaling (RGS) domain superfamily
    cl28922
    Location:231 → 303
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  2. XM_047416060.1 → XP_047272016.1  regulator of G-protein signaling 12 isoform X7

  3. XM_017008529.3 → XP_016864018.1  regulator of G-protein signaling 12 isoform X1

    UniProtKB/Swiss-Prot
    B1AQ30, B1AQ31, B1AQ32, B7Z764, E7EMN9, O14922, O14923, O14924, O43510, O75338, Q147X0, Q8WX95
    Conserved Domains (9) summary
    cd08742
    Location:716 → 830
    RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein
    smart00390
    Location:1188 → 1209
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    cd00992
    Location:20 → 96
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13162
    Location:228 → 359
    PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold
    cd17136
    Location:962 → 1031
    RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)
    pfam16611
    Location:1106 → 1180
    RGS12_us2; Unstructured region between RBD and GoLoco
    pfam16612
    Location:1239 → 1376
    RGS12_usC; C-terminal unstructured region of RGS12
    pfam16613
    Location:836 → 949
    RGS12_us1; Unstructured region of RGS12
    cl28922
    Location:1032 → 1104
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  4. XM_047416055.1 → XP_047272011.1  regulator of G-protein signaling 12 isoform X2

  5. XM_047416056.1 → XP_047272012.1  regulator of G-protein signaling 12 isoform X3

  6. XM_047416057.1 → XP_047272013.1  regulator of G-protein signaling 12 isoform X4

  7. XM_017008534.2 → XP_016864023.1  regulator of G-protein signaling 12 isoform X6

  8. XM_047416058.1 → XP_047272014.1  regulator of G-protein signaling 12 isoform X5

  9. XM_047416059.1 → XP_047272015.1  regulator of G-protein signaling 12 isoform X5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    3284640..3439697
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054350686.1 → XP_054206661.1  regulator of G-protein signaling 12 isoform X5

  2. XM_054350688.1 → XP_054206663.1  regulator of G-protein signaling 12 isoform X7

  3. XM_054350682.1 → XP_054206657.1  regulator of G-protein signaling 12 isoform X1

    UniProtKB/Swiss-Prot
    B1AQ30, B1AQ31, B1AQ32, B7Z764, E7EMN9, O14922, O14923, O14924, O43510, O75338, Q147X0, Q8WX95

  4. XM_054350683.1 → XP_054206658.1  regulator of G-protein signaling 12 isoform X2

  5. XM_054350685.1 → XP_054206660.1  regulator of G-protein signaling 12 isoform X3

  6. XM_054350684.1 → XP_054206659.1  regulator of G-protein signaling 12 isoform X8

  7. XM_054350687.1 → XP_054206662.1  regulator of G-protein signaling 12 isoform X6

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_198230.1: Suppressed sequence

    Description
    NM_198230.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

  2. NM_198430.1: Suppressed sequence

    Description
    NM_198430.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

  3. NM_198432.1: Suppressed sequence

    Description
    NM_198432.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

  4. NM_198587.1: Suppressed sequence

    Description
    NM_198587.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O14924.1 GenPept UniProtKB/Swiss-Prot:O14924

Gene LinkOut

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