U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

MCU Mitochondrial calcium uniporter [ Drosophila melanogaster (fruit fly) ]

Gene ID: 59223, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
MCUprovided by FlyBase
Official Full Name
Mitochondrial calcium uniporterprovided by FlyBase
Primary source
FLYBASE:FBgn0042185
Locus tag
Dmel_CG18769
See related
AllianceGenome:FB:FBgn0042185
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG18769; CG8352; dMCU1; Dmel\CG18769; mcu; Mcu
Summary
Enables calcium channel activity. Involved in several processes, including calcium import into the mitochondrion; memory; and mitochondrial calcium ion homeostasis. Located in mitochondrion. Is expressed in adult brain; adult head; adult optic lobe; and organism. Orthologous to several human genes including MCU (mitochondrial calcium uniporter). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See MCU in Genome Data Viewer
Location:
65B4-65B5; 3-17 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (6550738..6593940)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (6543838..6587040)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene sulfateless Neighboring gene long non-coding RNA:CR46500 Neighboring gene beta-Tubulin at 65B Neighboring gene javelin Neighboring gene long non-coding RNA:CR45418 Neighboring gene nudel Neighboring gene RNA exonuclease 5 Neighboring gene zero population growth

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Inhibiting the Mitochondrial Calcium Uniporter during Development Impairs Memory in Adult Drosophila. Drago I, et al. Cell Rep, 2016 Sep 6. PMID 27568554, Free PMC Article
  2. Activity of the mitochondrial calcium uniporter varies greatly between tissues. Fieni F, et al. Nat Commun, 2012. PMID 23271651, Free PMC Article
  3. Oxidative stress modulates rearrangement of endoplasmic reticulum-mitochondria contacts and calcium dysregulation in a Friedreich's ataxia model. Rodríguez LR, et al. Redox Biol, 2020 Oct. PMID 33128998, Free PMC Article
  4. Genetically targeted 3D visualisation of Drosophila neurons under Electron Microscopy and X-Ray Microscopy using miniSOG. Ng J, et al. Sci Rep, 2016 Dec 13. PMID 27958322, Free PMC Article
  5. Partial loss of MCU mitigates pathology in vivo across a diverse range of neurodegenerative disease models. Twyning MJ, et al. Cell Rep, 2024 Feb 27. PMID 38236772

See all (61) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MCU knockout flies are short lived compared to EMRE or MICU3 mutants. MCU loss blocks fast mitochondrial calcium uptake.
    Title: Comprehensive Genetic Characterization of Mitochondrial Ca(2+) Uniporter Components Reveals Their Different Physiological Requirements In Vivo.
  2. These results reveal an in vivo developmental role for the mitochondrial uniporter complex in establishing the necessary structural and functional neuronal substrates for normal memory formation in the adult organism.
    Title: Inhibiting the Mitochondrial Calcium Uniporter during Development Impairs Memory in Adult Drosophila.
  3. Data suggest that MCU plays key role in endoplasmic reticulum-to-mitochondrial calcium transfer and for cell death due to mitochondrial dysfunction under oxidative stress.
    Title: Mitochondrial calcium uniporter in Drosophila transfers calcium between the endoplasmic reticulum and mitochondria in oxidative stress-induced cell death.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium channel activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables calcium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables uniporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables uniporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in anesthesia-resistant memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in calcium import into the mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcium import into the mitochondrion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in medium-term memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial calcium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial calcium ion homeostasis IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial calcium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial calcium ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
part_of uniplex complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of uniplex complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of uniplex complex TAS
Traceable Author Statement
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
mitochondrial calcium uniporter
Names
CG18769-PA
CG18769-PB
CG18769-PC
CG18769-PD
CG18769-PE
CG18769-PG
CG18769-PH
CG18769-PI
MCU-PA
MCU-PB
MCU-PC
MCU-PD
MCU-PE
MCU-PG
MCU-PH
MCU-PI

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    6550738..6593940
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001259718.1 → NP_001246647.1  mitochondrial calcium uniporter, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246647.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8IQ70
    Conserved Domains (1) summary
    pfam04678
    Location:208 → 410
    MCU; Mitochondrial calcium uniporter

  2. NM_206280.2 → NP_996002.2  mitochondrial calcium uniporter, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996002.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8IQ70
    Conserved Domains (2) summary
    pfam02037
    Location:73 → 105
    SAP; SAP domain
    pfam04678
    Location:194 → 396
    MCU; Mitochondrial calcium uniporter

  3. NM_144449.4 → NP_652706.3  mitochondrial calcium uniporter, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_652706.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    E1NZC4, M9NF23, Q7KU70, Q8IQ70, X2JAQ2
    Related
    FBpp0076679
    Conserved Domains (1) summary
    pfam04678
    Location:117 → 319
    MCU; Mitochondrial calcium uniporter

  4. NM_168169.3 → NP_729173.1  mitochondrial calcium uniporter, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729173.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    E1NZC4, M9NF23, Q7KU70, Q8IQ70, X2JAQ2
    Related
    FBpp0076681
    Conserved Domains (1) summary
    pfam04678
    Location:117 → 319
    MCU; Mitochondrial calcium uniporter

  5. NM_206282.2 → NP_996004.1  mitochondrial calcium uniporter, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996004.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    E1NZC4, M9NF23, Q7KU70, Q8IQ70, X2JAQ2
    Conserved Domains (1) summary
    pfam04678
    Location:117 → 319
    MCU; Mitochondrial calcium uniporter

  6. NM_206281.2 → NP_996003.1  mitochondrial calcium uniporter, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996003.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8IQ70
    Conserved Domains (1) summary
    pfam04678
    Location:36 → 238
    MCU; Mitochondrial calcium uniporter

  7. NM_168170.2 → NP_729174.2  mitochondrial calcium uniporter, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729174.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    E1NZC4, M9NF23, Q7KU70, Q8IQ70, X2JAQ2
    Related
    FBpp0076680
    Conserved Domains (1) summary
    pfam04678
    Location:117 → 319
    MCU; Mitochondrial calcium uniporter

  8. NM_001300025.1 → NP_001286954.1  mitochondrial calcium uniporter, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286954.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8IQ70
    Conserved Domains (1) summary
    pfam04678
    Location:116 → 318
    MCU; Mitochondrial calcium uniporter
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IQ70.2 Q8IQ70

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous