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Gdap2 Gdap2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 59173, updated on 4-Jan-2025

Summary

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Official Symbol
Gdap2provided by FlyBase
Official Full Name
Gdap2provided by FlyBase
Primary source
FLYBASE:FBgn0042135
Locus tag
Dmel_CG18812
See related
AllianceGenome:FB:FBgn0042135
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG12040; CG18812; CG18813; Dmel\CG18812
Summary
Involved in response to oxidative stress and response to starvation. Is expressed in adult head. Used to study autosomal recessive spinocerebellar ataxia 27. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 27. Orthologous to human GDAP2 (ganglioside induced differentiation associated protein 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Gdap2 in Genome Data Viewer
Location:
43E12-43E13; 2-57 cM
Exon count:
16
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7716807..7735622, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3604312..3623127, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Diacylglycerol O-acyltransferase 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45108 Neighboring gene cinnabar

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. GDAP2 mutations implicate susceptibility to cellular stress in a new form of cerebellar ataxia. Eidhof I, et al. Brain, 2018 Sep 1. PMID 30084953, Free PMC Article
  2. Modulation of the activity of a polycomb-group response element in Drosophila by a mutation in the transcriptional activator woc. Noyes A, et al. G3 (Bethesda), 2011 Nov. PMID 22384357, Free PMC Article
  3. New Drosophila Long-Term Memory Genes Revealed by Assessing Computational Function Prediction Methods. Kacsoh BZ, et al. G3 (Bethesda), 2019 Jan 9. PMID 30463884, Free PMC Article
  4. Identification of Genes Contributing to a Long Circadian Period in Drosophila Melanogaster. Kumar S, et al. J Biol Rhythms, 2021 Jun. PMID 33274675, Free PMC Article
  5. Dynamic regulation of alternative splicing and chromatin structure in Drosophila gonads revealed by RNA-seq. Gan Q, et al. Cell Res, 2010 Jul. PMID 20440302, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in response to oxidative stress IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to starvation IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Gdap2
Names
CG18812-PA
CG18812-PB
CG18812-PC
CG18812-PD
CG18812-PE
CG18812-PF
Gdap2-PA
Gdap2-PB
Gdap2-PC
Gdap2-PD
Gdap2-PE
Gdap2-PF

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    7716807..7735622 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_165553.5 → NP_724598.1  Gdap2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724598.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z741
    Related
    FBpp0088010
    Conserved Domains (1) summary
    pfam13716
    Location:97 → 228
    CRAL_TRIO_2; Divergent CRAL/TRIO domain

  2. NM_165554.4 → NP_724599.1  Gdap2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724599.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z742, C9QPK4
    Related
    FBpp0088011
    Conserved Domains (1) summary
    pfam13716
    Location:70 → 201
    CRAL_TRIO_2; Divergent CRAL/TRIO domain

  3. NM_001273860.2 → NP_001260789.1  Gdap2, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260789.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KEL9, C9QPK4
    Conserved Domains (1) summary
    pfam13716
    Location:70 → 193
    CRAL_TRIO_2; Divergent CRAL/TRIO domain

  4. NM_165552.5 → NP_724597.1  Gdap2, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724597.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7JUR6
    Related
    FBpp0088009
    Conserved Domains (3) summary
    COG2110
    Location:67 → 234
    YmdB; O-acetyl-ADP-ribose deacetylase (regulator of RNase III), contains Macro domain [Translation, ribosomal structure and biogenesis]
    cd02905
    Location:67 → 207
    Macro_GDAP2_like; Macro domain, GDAP2_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose ...
    pfam13716
    Location:393 → 518
    CRAL_TRIO_2; Divergent CRAL/TRIO domain

  5. NM_001273861.2 → NP_001260790.1  Gdap2, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260790.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KFB9
    Conserved Domains (3) summary
    COG2110
    Location:67 → 234
    YmdB; O-acetyl-ADP-ribose deacetylase (regulator of RNase III), contains Macro domain [Translation, ribosomal structure and biogenesis]
    cd02905
    Location:67 → 207
    Macro_GDAP2_like; Macro domain, GDAP2_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose ...
    pfam13716
    Location:387 → 512
    CRAL_TRIO_2; Divergent CRAL/TRIO domain

  6. NM_001259262.2 → NP_001246191.1  Gdap2, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246191.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D1Z396
    Conserved Domains (1) summary
    pfam13716
    Location:117 → 248
    CRAL_TRIO_2; Divergent CRAL/TRIO domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KEL9 A0A0B4KEL9
A0A0B4KFB9 A0A0B4KFB9
A1Z741 A1Z741
A1Z742 A1Z742
D1Z396 D1Z396
Q7JUR6.1 Q7JUR6

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