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Fkbp1b FKBP prolyl isomerase 1B [ Rattus norvegicus (Norway rat) ]

Gene ID: 58950, updated on 4-Jan-2025

Summary

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Official Symbol
Fkbp1bprovided by RGD
Official Full Name
FKBP prolyl isomerase 1Bprovided by RGD
Primary source
RGD:61835
See related
EnsemblRapid:ENSRNOG00000047143 AllianceGenome:RGD:61835
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
FKBP-1B; FKBP-12.6
Summary
Enables FK506 binding activity and cyclic nucleotide binding activity. Involved in several processes, including positive regulation of axon regeneration; response to hydrogen peroxide; and response to vitamin E. Predicted to be located in Z disc; membrane; and sarcoplasmic reticulum. Predicted to be part of calcium channel complex. Predicted to be active in sarcoplasmic reticulum membrane. Biomarker of cardiomyopathy and congestive heart failure. Human ortholog(s) of this gene implicated in Graves' disease. Orthologous to human FKBP1B (FKBP prolyl isomerase 1B). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Brain (RPKM 130.6), Kidney (RPKM 46.2) and 3 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Fkbp1b in Genome Data Viewer
Location:
6q14
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (33551583..33570055, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (27832128..27850600, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (29975863..29987252)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene profilin family, member 4 Neighboring gene tumor protein p53 inducible protein 3 Neighboring gene splicing factor 3B, subunit 6 Neighboring gene U6 spliceosomal RNA Neighboring gene WD repeat and coiled coil containing Neighboring gene MFSD2 lysolipid transporter B, sphingolipid

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. FK506-Binding Protein 12.6/1b, a Negative Regulator of [Ca(2+)], Rescues Memory and Restores Genomic Regulation in the Hippocampus of Aging Rats. Gant JC, et al. J Neurosci, 2018 Jan 24. PMID 29255009, Free PMC Article
  2. Reversal of Aging-Related Neuronal Ca2+ Dysregulation and Cognitive Impairment by Delivery of a Transgene Encoding FK506-Binding Protein 12.6/1b to the Hippocampus. Gant JC, et al. J Neurosci, 2015 Jul 29. PMID 26224869, Free PMC Article
  3. Dissociation of FK506-binding protein 12.6 kD from ryanodine receptor in bronchial smooth muscle cells in airway hyperresponsiveness in asthma. Du Y, et al. Am J Respir Cell Mol Biol, 2014 Feb. PMID 24053175, Free PMC Article
  4. Disrupting function of FK506-binding protein 1b/12.6 induces the Ca²+-dysregulation aging phenotype in hippocampal neurons. Gant JC, et al. J Neurosci, 2011 Feb 2. PMID 21289178, Free PMC Article
  5. Down-regulation of FKBP12.6 and SERCA2a contributes to acute heart failure in septic shock and is related to an up-regulated endothelin signalling pathway. He HB, et al. J Pharm Pharmacol, 2007 Jul. PMID 17637193

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. a previously unrecognized genomic network modulating diverse brain structural processes is dysregulated by aging and restored by FKBP1b overexpression
    Title: FK506-Binding Protein 12.6/1b, a Negative Regulator of [Ca(2+)], Rescues Memory and Restores Genomic Regulation in the Hippocampus of Aging Rats.
  2. raising FKBP1b reversed calcium dysregulation and memory impairment in aging rats, allowing them to perform a memory task as well as young rats
    Title: Reversal of Aging-Related Neuronal Ca2+ Dysregulation and Cognitive Impairment by Delivery of a Transgene Encoding FK506-Binding Protein 12.6/1b to the Hippocampus.
  3. Dissociation of FK506-binding protein 12.6 kD from ryanodine receptor 2 in bronchial smooth muscle cells is responsible for the increased calcium response contributing to AHR in asthma
    Title: Dissociation of FK506-binding protein 12.6 kD from ryanodine receptor in bronchial smooth muscle cells in airway hyperresponsiveness in asthma.
  4. The effects of FKBP12.6 and another structurally similar molecule, FKBP12, which is far more abundant in heart, on the gating of single sheep RyR2 channels, were investigated.
    Title: FKBP12 activates the cardiac ryanodine receptor Ca2+-release channel and is antagonised by FKBP12.6.
  5. Disruption of FKBP1b recapitulated much of the Ca(2+)-dysregulation aging phenotype in young rat hippocampus, supporting a novel hypothesis that declining FKBP function plays a major role in unhealthy brain aging.
    Title: Disrupting function of FK506-binding protein 1b/12.6 induces the Ca²+-dysregulation aging phenotype in hippocampal neurons.
  6. Characterize the kinetics of FKBP12/12.6 binding to RyR2 in ventricular myocytes and effects on calcium signaling.
    Title: Kinetics of FKBP12.6 binding to ryanodine receptors in permeabilized cardiac myocytes and effects on Ca sparks.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables FK506 binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables FK506 binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II CTD heptapeptide repeat P3 isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II CTD heptapeptide repeat P6 isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables calcium channel inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables channel regulator activity ISO
Inferred from Sequence Orthology
more info
  
enables cyclic nucleotide binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptidyl-prolyl cis-trans isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptidyl-prolyl cis-trans isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidyl-prolyl cis-trans isomerase activity ISO
Inferred from Sequence Orthology
more info
  
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within T cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in calcium-mediated signaling ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within insulin secretion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of insulin secretion involved in cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of calcium-mediated signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of heart rate ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of insulin secretion involved in cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of release of sequestered calcium ion into cytosol ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neuronal action potential propagation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of axon regeneration IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cytosolic calcium ion concentration IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of sequestering of calcium ion ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of heart rate ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of ryanodine-sensitive calcium-release channel activity ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within release of sequestered calcium ion into cytosol ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to glucose ISO
Inferred from Sequence Orthology
more info
  
involved_in response to hydrogen peroxide IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to redox state ISO
Inferred from Sequence Orthology
more info
  
involved_in response to vitamin E IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within smooth muscle contraction ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Z disc ISO
Inferred from Sequence Orthology
more info
  
part_of calcium channel complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in sarcoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in sarcoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in sarcoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in sarcoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
peptidyl-prolyl cis-trans isomerase FKBP1B
Names
12.6 kDa FK506-binding protein
12.6 kDa FKBP
FK506-binding protein 1B
PPIase FKBP1B
calstabin-2
immunophilin FKBP12.6
rotamase
NP_001388191.1
NP_001388192.1
NP_073166.1
XP_017449825.1
XP_038968726.1
XP_038968727.1
XP_038968728.1
XP_038968730.1
XP_038968731.1
XP_038968733.1
XP_038968734.1
XP_063118449.1
XP_063118450.1
XP_063118451.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001401262.1 → NP_001388191.1  peptidyl-prolyl cis-trans isomerase FKBP1B isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    Related
    ENSRNOP00000100966.1, ENSRNOT00000137878.1
    Conserved Domains (1) summary
    pfam00254
    Location:6 → 89
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

  2. NM_001401263.1 → NP_001388192.1  peptidyl-prolyl cis-trans isomerase FKBP1B isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006

  3. NM_022675.2 → NP_073166.1  peptidyl-prolyl cis-trans isomerase FKBP1B isoform 1

    See identical proteins and their annotated locations for NP_073166.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/Swiss-Prot
    P97534
    UniProtKB/TrEMBL
    A6HAJ4
    Related
    ENSRNOP00000067023.1, ENSRNOT00000071784.4
    Conserved Domains (1) summary
    pfam00254
    Location:13 → 105
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    33551583..33570055 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039112806.2 → XP_038968734.1  peptidyl-prolyl cis-trans isomerase FKBP1B isoform X9

    Conserved Domains (1) summary
    pfam00254
    Location:6 → 47
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

  2. XM_039112798.2 → XP_038968726.1  peptidyl-prolyl cis-trans isomerase FKBP1B isoform X1

  3. XM_039112803.2 → XP_038968731.1  peptidyl-prolyl cis-trans isomerase FKBP1B isoform X5

    Conserved Domains (1) summary
    pfam00254
    Location:13 → 91
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

  4. XM_039112802.2 → XP_038968730.1  peptidyl-prolyl cis-trans isomerase FKBP1B isoform X4

    Conserved Domains (1) summary
    pfam00254
    Location:13 → 63
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

  5. XM_017594336.3 → XP_017449825.1  peptidyl-prolyl cis-trans isomerase FKBP1B isoform X8

    Conserved Domains (1) summary
    pfam00254
    Location:1 → 76
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

  6. XM_063262381.1 → XP_063118451.1  peptidyl-prolyl cis-trans isomerase FKBP1B isoform X8

  7. XM_039112800.2 → XP_038968728.1  peptidyl-prolyl cis-trans isomerase FKBP1B isoform X3

    Conserved Domains (1) summary
    pfam00254
    Location:6 → 68
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

  8. XM_039112805.2 → XP_038968733.1  peptidyl-prolyl cis-trans isomerase FKBP1B isoform X7

    Related
    ENSRNOP00000092320.1, ENSRNOT00000119856.2
    Conserved Domains (1) summary
    pfam00254
    Location:13 → 63
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

  9. XM_063262380.1 → XP_063118450.1  peptidyl-prolyl cis-trans isomerase FKBP1B isoform X6

  10. XM_063262379.1 → XP_063118449.1  peptidyl-prolyl cis-trans isomerase FKBP1B isoform X6

  11. XM_039112799.2 → XP_038968727.1  peptidyl-prolyl cis-trans isomerase FKBP1B isoform X2

    Related
    ENSRNOP00000100814.1, ENSRNOT00000165266.1
    Conserved Domains (1) summary
    pfam00254
    Location:13 → 84
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

RNA

  1. XR_005505573.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97534.3 GenPept UniProtKB/Swiss-Prot:P97534

Gene LinkOut

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