Ccnd1 cyclin D1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ccnd1provided by RGD
Official Full Name: cyclin D1provided by RGD
Primary source: RGD:68384
See related: EnsemblRapid:ENSRNOG00000020918 AllianceGenome:RGD:68384
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables protein kinase binding activity. Involved in several processes, including Leydig cell differentiation; response to corticosterone; and response to vitamin E. Predicted to be located in bicellular tight junction and nucleoplasm. Predicted to be part of cyclin D1-CDK4 complex; cyclin D1-CDK6 complex; and transcription repressor complex. Predicted to be active in cytoplasm; microtubule organizing center; and nucleus. Used to study prostate cancer and status epilepticus. Biomarker of several diseases, including atherosclerosis; impotence; interstitial cystitis; liver cancer; and visual epilepsy. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); colorectal cancer; hematologic cancer (multiple); invasive lobular carcinoma; and von Hippel-Lindau disease. Orthologous to human CCND1 (cyclin D1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 417.0), Lung (RPKM 379.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q42

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (209518288..209527986, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (200089002..200098524, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (218090750..218100447, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cyclin D1-Cdk4 regulates neuronal activity through phosphorylation of GABAA receptors.
Title: Cyclin D1-Cdk4 regulates neuronal activity through phosphorylation of GABAA receptors.
Sublytic C5b-9 induces glomerular mesangial cell proliferation via ERK1/2-dependent SOX9 phosphorylation and acetylation by enhancing Cyclin D1 in rat Thy-1 nephritis.
Title: Sublytic C5b-9 induces glomerular mesangial cell proliferation via ERK1/2-dependent SOX9 phosphorylation and acetylation by enhancing Cyclin D1 in rat Thy-1 nephritis.
Extracellular vesicles from neurons promote neural induction of stem cells through cyclin D1.
Title: Extracellular vesicles from neurons promote neural induction of stem cells through cyclin D1.
Ubiquitin-specific protease 2 regulates Ang -induced cardiac fibroblasts activation by up-regulating cyclin D1 and stabilizing beta-catenin in vitro.
Title: Ubiquitin-specific protease 2 regulates Ang Ⅱ-induced cardiac fibroblasts activation by up-regulating cyclin D1 and stabilizing β-catenin in vitro.
Influence of Cilostazol on Changes in Cyclin D1 Expression in Cerebral Cortex of Rats with Chronic Cerebral Ischemia.
Title: Influence of Cilostazol on Changes in Cyclin D1 Expression in Cerebral Cortex of Rats with Chronic Cerebral Ischemia.
Effects of Bisphenol A Exposure during Pregnancy and lactation on Hippocampal Function in Newborn Rats.
Title: Effects of Bisphenol A Exposure during Pregnancy and lactation on Hippocampal Function in Newborn Rats.
PLCG2 plays an important role in rat liver cell proliferation via ERK and NF-kappaB pathway by regulating the expression of BCl2, MYC and CCND1
Title: PLCG2 promotes hepatocyte proliferation in vitro via NF-κB and ERK pathway by targeting bcl2, myc and ccnd1.
Shifts in Cyclin D1 and IL-33 expression may identify severely macrosteatotic livers with increased failure risk if subjected to ischemia reperfusion injury.
Title: Interleukin-33 / Cyclin D1 imbalance in severe liver steatosis predicts susceptibility to ischemia reperfusion injury.
LncRNA H19 positively regulated cyclin D1 expression through directly binding to let-7a in vascular smooth muscle cells.
Title: Long noncoding RNA H19 promotes vascular remodeling by sponging let-7a to upregulate the expression of cyclin D1.
Our study provides evidence that epigenetic silencing of CyclinD1 using bone marrow-derived mesenchymal stem cells might accelerate the repair of spinal cord injury in rats
Title: Protective effect of epigenetic silencing of CyclinD1 against spinal cord injury using bone marrow-derived mesenchymal stem cells in rats.

Submit: New GeneRIF Correction See all GeneRIFs (94)

General gene information

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Markers

PMC98458P1 (e-PCR)
- UniSTS:273670

UniSTS:465472 (e-PCR)
- UniSTS:465472

Ccnd1 (e-PCR), detects polymorphism
- UniSTS:465472

RH133876 (e-PCR)
- UniSTS:217159

Ccnd1 (e-PCR), detects polymorphism
- UniSTS:531327

BI280117 (e-PCR)
- UniSTS:249021

Ccnd1 (e-PCR), detects polymorphism
- UniSTS:141255

Ccnd1 (e-PCR), detects polymorphism
- UniSTS:141256

D1Wox59 (e-PCR)
- UniSTS:239564

PMC321442P2 (e-PCR)
- UniSTS:273110

RH134541 (e-PCR)
- UniSTS:217821

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cyclin-dependent protein serine/threonine kinase activator activity	IEA Inferred from Electronic Annotation more info
enables cyclin-dependent protein serine/threonine kinase activator activity	ISO Inferred from Sequence Orthology more info
enables cyclin-dependent protein serine/threonine kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables cyclin-dependent protein serine/threonine kinase regulator activity	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables histone deacetylase binding	IEA Inferred from Electronic Annotation more info
enables histone deacetylase binding	ISO Inferred from Sequence Orthology more info
enables kinase activity	ISO Inferred from Sequence Orthology more info
enables proline-rich region binding	IEA Inferred from Electronic Annotation more info
enables proline-rich region binding	ISO Inferred from Sequence Orthology more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription corepressor activity	IEA Inferred from Electronic Annotation more info
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info
enables transcription corepressor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	ISS Inferred from Sequence or Structural Similarity more info
involved_in G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in G1/S transition of mitotic cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in G1/S transition of mitotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in G1/S transition of mitotic cell cycle	NAS Non-traceable Author Statement more info	PubMed
involved_in Leydig cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in animal organ regeneration	IEP Inferred from Expression Pattern more info	PubMed
involved_in cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in endoplasmic reticulum unfolded protein response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within endoplasmic reticulum unfolded protein response	ISO Inferred from Sequence Orthology more info
involved_in fat cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in lactation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lactation	ISO Inferred from Sequence Orthology more info
involved_in liver development	IEP Inferred from Expression Pattern more info	PubMed
involved_in liver regeneration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within liver regeneration	ISO Inferred from Sequence Orthology more info
involved_in mammary gland alveolus development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mammary gland alveolus development	ISO Inferred from Sequence Orthology more info
involved_in mammary gland epithelial cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of mammary gland epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mammary gland epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in mitotic G1 DNA damage checkpoint signaling	IEA Inferred from Electronic Annotation more info
involved_in mitotic G1 DNA damage checkpoint signaling	ISO Inferred from Sequence Orthology more info
involved_in mitotic G1 DNA damage checkpoint signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of epithelial cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuron differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of G2/M transition of mitotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of G2/M transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of G2/M transition of mitotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cyclin-dependent protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cyclin-dependent protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of mammary gland epithelial cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of mammary gland epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in re-entry into mitotic cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within re-entry into mitotic cell cycle	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in response to UV-A	IEA Inferred from Electronic Annotation more info
involved_in response to UV-A	ISO Inferred from Sequence Orthology more info
involved_in response to UV-A	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to X-ray	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to calcium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to corticosterone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to estrogen	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucocorticoid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to iron ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to leptin	IEA Inferred from Electronic Annotation more info
involved_in response to leptin	ISO Inferred from Sequence Orthology more info
involved_in response to magnesium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to steroid hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to vitamin E	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in bicellular tight junction	IEA Inferred from Electronic Annotation more info
located_in bicellular tight junction	ISO Inferred from Sequence Orthology more info
part_of cyclin D1-CDK4 complex	IEA Inferred from Electronic Annotation more info
part_of cyclin D1-CDK4 complex	ISO Inferred from Sequence Orthology more info
part_of cyclin D1-CDK6 complex	IEA Inferred from Electronic Annotation more info
part_of cyclin D1-CDK6 complex	ISO Inferred from Sequence Orthology more info
part_of cyclin-dependent protein kinase holoenzyme complex	IBA Inferred from Biological aspect of Ancestor more info
part_of cyclin-dependent protein kinase holoenzyme complex	ISO Inferred from Sequence Orthology more info
part_of cyclin-dependent protein kinase holoenzyme complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in microtubule organizing center	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of transcription repressor complex	IEA Inferred from Electronic Annotation more info
part_of transcription repressor complex	ISO Inferred from Sequence Orthology more info
part_of transcription repressor complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: G1/S-specific cyclin-D1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_171992.6 → NP_741989.3 G1/S-specific cyclin-D1

See identical proteins and their annotated locations for NP_741989.3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

P39948

UniProtKB/TrEMBL

A6HYI6, A6HYI8

Related

ENSRNOP00000075372.3, ENSRNOT00000088588.3

Conserved Domains (2) summary

cd20573
Location:3 → 151

CYCLIN_CCND1_rpt1; first cyclin box found in G1/S-specific cyclin-D1 (CCND1)

cd20576
Location:156 → 265

CYCLIN_CCND1_rpt2; second cyclin box found in G1/S-specific cyclin-D1 (CCND1)