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Gpr180 G protein-coupled receptor 180 [ Mus musculus (house mouse) ]

Gene ID: 58245, updated on 27-Nov-2024

Summary

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Official Symbol
Gpr180provided by MGI
Official Full Name
G protein-coupled receptor 180provided by MGI
Primary source
MGI:MGI:1930949
See related
Ensembl:ENSMUSG00000022131 AllianceGenome:MGI:1930949
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Itr; E130016I23Rik
Summary
Predicted to be involved in G protein-coupled receptor signaling pathway and response to pheromone. Predicted to be located in membrane. Is expressed in embryo. Orthologous to human GPR180 (G protein-coupled receptor 180). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in ovary adult (RPKM 17.9), limb E14.5 (RPKM 15.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Gpr180 in Genome Data Viewer
Location:
14 E4; 14 61.78 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (118374513..118401644)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (118137105..118164232)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7351 Neighboring gene nuclear encoded tRNA pheylalanine 5 (anticodon GAA) Neighboring gene predicted gene, 31633 Neighboring gene STARR-seq mESC enhancer starr_37634 Neighboring gene TDP-glucose 4,6-dehydratase Neighboring gene STARR-positive B cell enhancer ABC_E7352 Neighboring gene predicted gene 4674 Neighboring gene RIKEN cDNA 4933431J24 gene Neighboring gene predicted gene, 31981

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Hepatic G Protein-Coupled Receptor 180 Deficiency Ameliorates High Fat Diet-Induced Lipid Accumulation via the Gi-PKA-SREBP Pathway. Zhang Y, et al. Nutrients, 2023 Apr 11. PMID 37111058, Free PMC Article
  2. Inhibition of experimental intimal thickening in mice lacking a novel G-protein-coupled receptor. Tsukada S, et al. Circulation, 2003 Jan 21. PMID 12538434
  3. GPR180 is a component of TGFβ signalling that promotes thermogenic adipocyte function and mediates the metabolic effects of the adipocyte-secreted factor CTHRC1. Balazova L, et al. Nat Commun, 2021 Dec 8. PMID 34880217, Free PMC Article
  4. Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives. Tamplin OJ, et al. BMC Genomics, 2008 Oct 30. PMID 18973680, Free PMC Article
  5. A global genomic transcriptional code associated with CNS-expressed genes. Bailey PJ, et al. Exp Cell Res, 2006 Oct 1. PMID 16919269

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hepatic G Protein-Coupled Receptor 180 Deficiency Ameliorates High Fat Diet-Induced Lipid Accumulation via the Gi-PKA-SREBP Pathway.
    Title: Hepatic G Protein-Coupled Receptor 180 Deficiency Ameliorates High Fat Diet-Induced Lipid Accumulation via the Gi-PKA-SREBP Pathway.
  2. GPR180 is a component of TGFbeta signalling that promotes thermogenic adipocyte function and mediates the metabolic effects of the adipocyte-secreted factor CTHRC1.
    Title: GPR180 is a component of TGFβ signalling that promotes thermogenic adipocyte function and mediates the metabolic effects of the adipocyte-secreted factor CTHRC1.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in response to pheromone IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
integral membrane protein GPR180
Names
intimal thickness-related receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021434.5 → NP_067409.2  integral membrane protein GPR180 precursor

    See identical proteins and their annotated locations for NP_067409.2

    Status: VALIDATED

    Source sequence(s)
    AC108833, AK053422, CX210992
    Consensus CDS
    CCDS27333.1
    UniProtKB/Swiss-Prot
    Q8BPS4, Q9JJG1
    Related
    ENSMUSP00000022728.3, ENSMUST00000022728.4
    Conserved Domains (1) summary
    pfam10192
    Location:144 → 406
    GpcrRhopsn4; Rhodopsin-like GPCR transmembrane domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    118374513..118401644
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247903.1 → XP_030103763.1  integral membrane protein GPR180 isoform X2

    Conserved Domains (1) summary
    pfam10192
    Location:1 → 258
    GpcrRhopsn4; Rhodopsin-like GPCR transmembrane domain

  2. XM_006519335.4 → XP_006519398.1  integral membrane protein GPR180 isoform X1

    Conserved Domains (1) summary
    pfam10192
    Location:99 → 339
    GpcrRhopsn4; Rhodopsin-like GPCR transmembrane domain

RNA

  1. XR_383197.5 RNA Sequence

  2. XR_003950877.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BPS4.1 GenPept UniProtKB/Swiss-Prot:Q8BPS4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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